Results 41 to 50 of about 162,489 (254)

Enhanced prediction of cholecystectomy using obesity-modified TyG indices: a machine learning and SHAP-based study

European Journal of Medical Research
Background This study investigates the association between TyG-related composite indices and the risk of gallstones and the history of cholecystectomy, using logistic regression and machine learning models to evaluate predictive performance and clinical ...
Yue Zhang, Ruifeng Duan, Xin Chen, Lijuan Wei   +3 more
doaj   +1 more source

Triglyceride-Glucose Index in the Prediction of Prediabetes

Revista Eugenio Espejo
Prediabetes is a metabolic disorder characterized by insulin resistance long before the diagnosis of type 2 diabetes mellitus (T2DM) and represents a key opportunity for intervention and prevention of T2DM. The triglyceride-glucose index (TGI) has been identified as an accessible marker of insulin resistance with potential diagnostic value.
Jorman Francisco Choez Alava, Marja Morales Baldeon, Carmen Vanessa Vaca Vera, Bertha Carolina Cruz Murillo   +3 more
openaire   +1 more source

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cells During Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

Second‐trimester triglyceride‐glucose index to predict adverse outcomes in women with gestational diabetes mellitus: A retrospective multicenter cohort study

Journal of Diabetes Investigation
Aims/Introduction Women with gestational diabetes mellitus are at high risk for adverse maternal and neonatal outcomes. The study aimed to evaluate the performance of the triglyceride‐glucose index in predicting the risk of developing adverse outcomes in
Xueqi Bai, Qingyi Zhu, Wenli Wang, Sutong Kan, Shiman Hu, Runrun Hao, Shanshan Wang, Zhonghua Shi   +7 more
doaj   +1 more source

Triglyceride glucose index: a novel biomarker in the management of patients with psoriasis.

European review for medical and pharmacological sciences, 2023
Triglyceride glucose index is a recently described biomarker that has been associated with various systemic disorders such as cardiovascular diseases. Within this study, we evaluated the effect of biological agent treatment on triglyceride glucose index in patients with psoriasis.Between April 2019 and October 2022, the triglyceride glucose index was ...
Atliya, Osmanege, Aksakal, Ahmet Burhan, Tamer, FUNDA   +2 more
openaire   +3 more sources

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Triglyceride glucose index, its modified indices, and triglyceride HDL-C ratio as predictor markers of insulin resistance in prediabetic individuals

Medical Journal of Babylon, 2023
Background: Prediabetes is a strong hazard for developing of both cardiovascular disorders and diabetes mellitus. Insulin resistant predisposes to prediabetes and type 2 diabetes mellitus that all are strongly correlated with development of ...
Rojeen Rasheed Suleiman, Sherwan Ferman Salih, Barhav Issa Abdullah, Ibrahim Hasan Ibrahim, Zindan Azeez Saeed   +4 more
doaj   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Adiposity indicators lipid accumulation product and triglyceride-glucose index as alternate criteria for the diagnosis of metabolic obesity in adult

Bangabandhu Sheikh Mujib Medical University Journal, 2018
Metabolic obesity refers to the state of having metabolic syndrome irrespective of one’s body mass index. This study was aimed to elucidate the lipid accumulation product and triglyceride-glucose index as simple and alternate criteria for detecting ...
Mariya Tabassum, Md. Matiur Rahman, Miliva Mozaffor   +2 more
doaj   +1 more source

Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design

Advanced Science, EarlyView.
This study reveals how surfactant‐driven interfacial design governs the assembly and stability of protein@MOF composites. Using lipid‐based nonionic surfactants, we modulate protein–MOF interactions to improve encapsulation efficiency, MOF crystallization, and catalytic performance.
Ehsan Rashidniyaghi, Mohammad Khavani, Carlie Coerver, Ruibin Liang, Raheleh Ravanfar   +4 more
wiley   +1 more source