Results 21 to 30 of about 472,656 (344)

A novel homozygous missense mutation in PNPLA2 in a patient manifesting primary triglyceride deposit cardiomyovasculopathy

Molecular Genetics and Metabolism Reports, 2023
Primary triglyceride deposit cardiomyovasculopathy (P-TGCV), caused by a rare genetic mutation in PNPLA2 encoding adipose triglyceride lipase (ATGL), exhibits severe cardiomyocyte steatosis and heart failure. Here, we report the case of a 51-year-old man
Yasuhiro Hara, Yoshihiko Ikeda, Hayato Kimura, Shinsaku Shimamoto, Mao Ishikawa, Kunihisa Kobayashi, Hironori Nagasaka, Hisashi Shimoyama, Ken-ichi Hirano   +8 more
doaj  

Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome.

New England Journal of Medicine, 2019
BACKGROUND Familial chylomicronemia syndrome is a rare genetic disorder that is caused by loss of lipoprotein lipase activity and characterized by chylomicronemia and recurrent episodes of pancreatitis. There are no effective therapies.
J. Witztum, D. Gaudet, Steven D Freedman, V. Alexander, Andres Digenio, Karren R. Williams, Qingqing Yang, Steven G. Hughes, Richard S. Geary, M. Arca, E. Stroes, Jean Bergeron, H. Soran, F. Civeira, Linda Hemphill, S. Tsimikas, D. Blom, Louis O'Dea, E. Bruckert   +18 more
semanticscholar   +1 more source

Increased residual cardiovascular risk in U.S. veterans with moderately-elevated baseline triglycerides and well-controlled LDL-C levels on statins

Frontiers in Cardiovascular Medicine, 2022
BackgroundRecent studies have demonstrated a causal role for elevated triglycerides (TG) in incident cardiovascular (CV) events in patients with established coronary heart disease (CHD) and those with CV risk factors alone, particularly diabetes ...
Sarah Leatherman, Sarah Leatherman, Ryan Ferguson, Ryan Ferguson, Cynthia Hau, Kelly Harrington, Kelly Harrington, Craig Granowitz, Sephy Philip, Peter Paul Toth, Deepak Bhatt, William Boden, William Boden   +12 more
doaj   +1 more source

Is Triglyceride Atherogenic? [PDF]

Korean Clinical Diabetes, 2009
Fig. 1과 같이 중성지방(TAG) 입자들은 지방세포에 많이 함입되어 저장된다. 당과 같이 저장되는 과정에는 인슐린의 동화작용이 관여하게 된다. 이러한 중성지방은 가수분해되 어 non-esterified fatty acid의 형태로 유리되어 간으로 전달 된다. 특히 인슐린저항성(Fig. 2 중 IR) 상황에서는 카테콜라민 이나 글루코르티코이드 등의 스트레스 호르몬의 자극에 대 해 지방세포가 민감하게 반응하기 때문에 많은 양의 유리지 방산이 생산되며 이는 간으로 흡수되어 중성지방을 만드는 원료로 쓰인다. Fig.
openaire   +2 more sources

The Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans

Frontiers in Endocrinology, 2020
Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to CVD,
J. Borén, C. Packard, M. Taskinen
semanticscholar   +1 more source

Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.

Journal of Clinical Investigation, 2020
Visceral adipose tissue plays a critical role in numerous diseases. While imaging studies often show adipose involvement in abdominal diseases, their outcomes may vary from being a mild self limited illness to one with systemic inflammation and organ ...
Cristiane de Oliveira, Biswajit Khatua, Pawan Noel, Sergiy Kostenko, A. Bag, Bijinu Balakrishnan, Krutika Patel, Andre Guerra, Melissa N. Martinez, Shubham Trivedi, A. McCullough, D. Lam-Himlin, S. Navina, D. Faigel, N. Fukami, R. Pannala, A. Phillips, G. Papachristou, E. Kershaw, M. Lowe, Vijay P. Singh   +20 more
semanticscholar   +1 more source

Hypertriglyceridemia and preeclampsia: Its physiological role and up-to-date evidence [PDF]

MedUNAB, 2005
Preeclampsia is a disease with a highincidence for maternal and fetal morbidity and mortality, mainly indeveloping countries. Although its etiology remains unclear, severalstudies have shown that endothelial cell dysfunction plays an important role in ...
María Paula Martínez Linares, Juan Guillermo Lozano de Castro   +1 more
doaj  

The nonlinear correlation between the cardiometabolic index and the risk of diabetes: A retrospective Japanese cohort study

Frontiers in Endocrinology, 2023
BackgroundThe cardiometabolic index (CMI) has been proposed as a novel indicator of cardiometabolic status. However, evidence on the relationship between CMI and diabetes mellitus (DM) risk was limited. Our study aimed to explore the relationship between
Fubing Zha, Fubing Zha, Changchun Cao, Mengru Hong, Huili Hou, Qionghua Zhang, Bin Tang, Haofei Hu, Yong Han, Yibing Zan, Yulong Wang, Jianwen Xu   +11 more
doaj   +1 more source

A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown

PLoS Biology, 2020
Triglycerides are the major form of stored fat in all animals. One important determinant of whole-body fat storage is whether an animal is male or female.
Lianna W. Wat, Chien Chao, Rachael Bartlett, J. Buchanan, Jason W. Millington, H. Chih, Z. S. Chowdhury, Puja Biswas, V. Huang, Leah J Shin, Lin Chuan Wang, Marie-Pierre L. Gauthier, M. Barone, K. Montooth, M. Welte, Elizabeth J. Rideout   +15 more
semanticscholar   +1 more source

Role of triglycerides as a predictor of autoimmune hepatitis with cirrhosis

Lipids in Health and Disease, 2022
Background Metabolism-related indicators have been suggested as possible prognostic indicators of liver disease in recent relevant studies, but their value in predicting autoimmune hepatitis (AIH) cirrhosis is unclear.
Peng Wang, Yuqi Wang, Hui Liu, Xiaoxu Han, Yunyun Yi, Xin Wang, Xin Li   +6 more
doaj   +1 more source