Results 341 to 350 of about 455,452 (370)
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Triglycerides and cardiovascular disease
The Lancet, 2014After the introduction of statins, clinical emphasis first focussed on LDL cholesterol-lowering, then on the potential for raising HDL cholesterol, with less focus on lowering triglycerides. However, the understanding from genetic studies and negative results from randomised trials that low HDL cholesterol might not cause cardiovascular disease as ...
Anette Varbo +3 more
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Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase
Science, 2006Fat tissue is the most important energy depot in vertebrates. The release of free fatty acids (FFAs) from stored fat requires the enzymatic activity of lipases.
G. Haemmerle +14 more
semanticscholar +1 more source
The Triglyceride Connection in Atherosclerosis
Annals of Pharmacotherapy, 1992OBJECTIVE: To examine the proposed mechanism of triglyceride-induced atherogenesis, to address the controversy surrounding serum triglycerides as a coronary heart disease (CHD) risk factor, and to recommend an appropriate therapeutic approach to hypertriglyceridemia. DATA SOURCES: Studies, review articles, and editorials published since 1976. A MEDLINE
K Geurian, C W Weart, J B Pinson
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Journal of the American Oil Chemists' Society, 1979
AbstractTriglyceride separation was investigated on a reverse phase high performance liquid chromatography (HPLC) column using two different solvent systems. Complete separation of model compounds differing by two methylene groups was achieved. Partial or complete separation was also observed in critical pairs; for example, the different types of ...
B. Herslöf, B. Töregård, O. Podlaha
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AbstractTriglyceride separation was investigated on a reverse phase high performance liquid chromatography (HPLC) column using two different solvent systems. Complete separation of model compounds differing by two methylene groups was achieved. Partial or complete separation was also observed in critical pairs; for example, the different types of ...
B. Herslöf, B. Töregård, O. Podlaha
openaire +2 more sources
Triglycerides and gallstone formation
Clinica Chimica Acta, 2010Changes in bile acid (BA) metabolism and gallbladder function are critical factors in the pathogenesis of gallstones. Patients with hypertriglyceridemia (HTG) - often overweight and insulin resistant - are at risk for gallstone disease. The question arises whether HTG itself contributes to gallstone formation or whether gallstone disease only ...
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Current Opinion in Lipidology, 2017
Purpose of review We provide an overview of current evidence about the independent role of high triglyceride levels for cardiovascular risk and for acute pancreatitis. Recent findings Natural experiments of Mendelian randomization have given us a deeper understanding about the ...
Alicia J. Jenkins, Anthony C Keech
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Purpose of review We provide an overview of current evidence about the independent role of high triglyceride levels for cardiovascular risk and for acute pancreatitis. Recent findings Natural experiments of Mendelian randomization have given us a deeper understanding about the ...
Alicia J. Jenkins, Anthony C Keech
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Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
Nature Reviews Cardiology, 2022J. Borén +3 more
semanticscholar +1 more source
Triglyceride metabolism in pregnancy
2011During pregnancy, complex changes occur in lipid profiles. From the 12th week of gestation, phospholipids, cholesterol (total, LDL, HDL), and triglycerides (TG) increase in response to estrogen stimulation and insulin resistance. Transition to a catabolic state favors maternal tissue lipid use as energy sources, thus sparing glucose and amino acids for
Alessandra Bertolotto +4 more
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Fibrates and triglyceride metabolism
European Journal of Clinical Pharmacology, 1991Some mechanisms of the triglyceride-lowering effects of fibrates in patients with hypertriglyceridemia are reviewed. One main effect of the fibrates is the stimulation of lipoprotein lipase activities in plasma as well as in adipose tissue. According to this increase in the degradational activity VLDL catabolism is stimulated, as has been demonstrated ...
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Bioorganic & Medicinal Chemistry, 2014
This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids and ...
Sergey S. Laev +2 more
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This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids and ...
Sergey S. Laev +2 more
openaire +3 more sources