Results 81 to 90 of about 229,067 (324)
A Copula-based Fully Bayesian Nonparametric Evaluation of Cardiovascular Risk Markers in the Mexico City Diabetes Study [PDF]
arXiv, 2020 Cardiovascular disease lead the cause of death world wide and several studies have been carried out to understand and explore cardiovascular risk markers in normoglycemic and diabetic populations. In this work, we explore the association structure between hyperglycemic markers and cardiovascular risk markers controlled by triglycerides, body mass index,
arxiv
Advanced Science, EarlyView.This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang +13 more
wiley +1 more source
Advanced Science, EarlyView.This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu +11 more
wiley +1 more source
Multi-modal Predictive Models of Diabetes Progression [PDF]
, 2019 With the increasing availability of wearable devices, continuous monitoring of individuals' physiological and behavioral patterns has become significantly more accessible. Access to these continuous patterns about individuals' statuses offers an unprecedented opportunity for studying complex diseases and health conditions such as type 2 diabetes (T2D).
arxiv +1 more source
Advanced Science, EarlyView.PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao +11 more
wiley +1 more source
Control of poultry chicken malaria by surface functionalized amorphous nanosilica [PDF]
arXiv, 2007 Surface modified amorphous nanoporous silica molecules with hydrophobic as well as hydrophilic character can be effectively used as therapeutic drug for combating chicken malaria in poultry industry. The amorphous nanosilica was developed by top-down approach using volcanic soil derived silica as source material.
arxiv
Advanced Science, EarlyView.TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang +8 more
wiley +1 more source
Drug Design, Development and Therapy, 2020 Oluwayemisi Esan, Anthony S Wierzbicki Department of Metabolic Medicine/Chemical Pathology, Guy’s & St Thomas’ Hospitals, London SE1 7EH, UKCorrespondence: Anthony S WierzbickiDepartment of Chemical Pathology, St.
Esan O, Wierzbicki AS
doaj
Nanosilica mop up host lipids and fights baculovirus [PDF]
arXiv, 2007 Various types of surface functionalized nanosilica (50-60 nm size with 3-10 nm inner pore size range) have been used to kill insect pests by sucking up cuticular lipids and breaking the water barrier. We have also utilized nanosilica for mopping up host lipids induced by the malarial parasite, P. gallinaceum in poultry birds; VLDL cholesterol and serum
arxiv