Results 91 to 100 of about 10,516,949 (236)

Fatty liver disease is not associated with increased mortality in the elderly: A prospective cohort study

Hepatology, EarlyView., 2022
Graphical abstract summarizing the study design, main results and key findings Abstract Background and Aims Fatty liver disease (FLD) has been associated with excess mortality. Screening for hepatic steatosis (HS) in patients with metabolic dysfunction is therefore recommended by several guidelines, despite a paucity of evidence on the clinical ...
Laurens A. van Kleef, Milan J. Sonneveld, Maryam Kavousi, M. Arfan Ikram, Robert A. de Man, Robert J. de Knegt   +5 more
wiley   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality

Hepatology, EarlyView., 2022
Visualisation of the study desgin, main results and key findings. Abstract Background and Aims MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.
Laurens A. van Kleef, Robert J. de Knegt, Willem Pieter Brouwer   +2 more
wiley   +1 more source

Effect of blood flow restriction training on insulin resistance in men with metabolic syndrome: a randomized controlled trial

Вестник восстановительной медицины
Introduction. Metabolic syndrome is defined as a pathological condition characterized by abdominal obesity, hypertension, dyslipidemia, and impaired glucose tolerance. Insulin resistance is hypothesized to underlie metabolic syndrome.
Vadim V. Sverchkov, Evgeny V. Bykov
doaj   +1 more source

Quantifying Obesity in Economic Research: How Misleading is the Body Mass Index? [PDF]

Replaced with revised version of paper 07/19/10.Obesity, percent body fat (PBF), body mass index (BMI), economic costs, measurement error, Health Economics and Policy, Research and Development/Tech Change/Emerging Technologies, C52, I10,
Smith, Aaron D., Parks, Joanna C., Alston, Julian M.   +2 more
core  

Body mass index: a measure of fatness or leanness?

, 1995
The relationship between body fat and stature-adjusted weight indices was explored. Assuming the term height’ is a valid indicator of a subject’s lean body mass, heighplweight was shown to be an accurate measure of percentage lean body mass and, as such,
Holder, Roger L., Nevill, Alan M.
core   +3 more sources

Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis

Advanced Science, EarlyView.
A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen, Shen Zhang, Yuli Zhu, Da Zhou, Chunya Ji, Mingrui Zhu, Sirui Wang, Yuting Shen, Jifeng Yu, Heng Zhang, Yan Fang, Huixiong Xu, Haohao Yin   +12 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Prediction of Hypertension Risk in Patients with Fatty Liver Disease Using the Triglyceride-Glucose-Body Mass Index

Diabetes, Metabolic Syndrome and Obesity
Fatty liver disease (FLD) and hypertension (HTN) exhibit a bidirectional relationship: FLD elevates HTN risk, while HTN accelerates FLD progression to fibrosis. Research on this link is limited, with insulin resistance (IR) proposed as a key mechanism.
Ge Gao, Haitao Li, Zhikai Xu, Xiaochun Ge, Shuying Li, Yu Gao   +5 more
openaire   +3 more sources

Triglyceride-glucose index variability and incident cardiovascular disease: a prospective cohort study

, 2022
Background: Recent studies have suggested that triglyceride-glucose (TyG) index is an independent predictor of cardiovascular disease (CVD). However, the impact of long-term visit-to-visit variability in TyG index on the risk of CVD is not known.
X Guo (1378956), A Wang (4241158), F Qian (9854591), S Chen (5107745), Xia Li (9484709), S Wu (6794345), H Li (100694), P Wang (1542061), Y Zuo (9878198), X Tian (7942073)   +9 more
core   +1 more source