Results 71 to 80 of about 10,516,949 (236)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Dynamic Monitoring and Correlation Analysis of General Body Indicators, Blood Glucose, and Blood Lipid in Obese Cynomolgus Monkeys

Shiyan dongwu yu bijiao yixue
ObjectiveThis study aims to investigate the dynamic changes in general body parameters, blood glucose, and blood lipid profiles in obese cynomolgus monkeys, exploring the correlations among these parameters and providing a reference for research on the ...
WEI Yanye, SHEN Guo, ZHANG Pengfei, SHI Songping, HU Jiahao, ZHANG Xuzhe, HUA Huiyuan, HUA Guanyang, LU Hongzheng, ZENG Yong, JI Feng, WEI Zhumei   +11 more
doaj   +1 more source

Prevalence of hyperfiltration by serum triglyceride level and diabetes status after adjusting for clinical and metabolic parameters*.

, 2018
NGT, normal glucose tolerance. * age, sex, body weight, body mass index, waist circumference, systolic blood pressure, and energy intake ...
Yun Mi Choi (732104), Eun-Gyoung Hong (363850), Sangmo Hong (2610259), Sung-Hee Ihm (6058172), Dooman Kim (6058175), Moon-Gi Choi (763757), Jae Myung Yu (4471231)   +6 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Enhanced prediction of cholecystectomy using obesity-modified TyG indices: a machine learning and SHAP-based study

European Journal of Medical Research
Background This study investigates the association between TyG-related composite indices and the risk of gallstones and the history of cholecystectomy, using logistic regression and machine learning models to evaluate predictive performance and clinical ...
Yue Zhang, Ruifeng Duan, Xin Chen, Lijuan Wei   +3 more
doaj   +1 more source

Triglyceride glucose-body mass index is effective in identifying nonalcoholic fatty liver disease in nonobese subjects

Medicine, 2017
Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is highly correlated with obesity; however, it is not uncommon among nonobese individuals. Triglyceride (TG) and glucose index combined with body mass index (TyG-BMI) has been proposed as a favorable marker of insulin resistance. We sought to investigate the effectiveness
Zhang, Shujun, Du, Tingting, Li, Mengni, Jia, Jing, Lu, Huiming, Lin, Xuan, Yu, Xuefeng   +6 more
openaire   +2 more sources

Triglyceride-Glucose Index Levels Positively Associated with Higher Risk of Low Muscle Mass in Patients with Type 2 Diabetes [PDF]

Qinying Zhao,* Ziyue Zhang,* Shuo Li, Ming Liu Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Liu,
Li S, Zhang Z, Liu M, Zhao Q
core  

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Association between body mass index and cardiometabolic risks among Malay obese adults [PDF]

, 2019
Cardiometabolic risk (CMR) is a cluster of risk factors that may predict the occurrence of cardiovascular diseases and diabetes mellitus. This study investigated the association between CMR with body mass index (BMI) among obese adults.
Shahadan, Siti Zuhaidah, Daud, Azlina
core   +2 more sources

Correlation of triglyceride glucose–body mass index, bedside index for severity in acute pancreatitis, and C-reactive protein-to-lymphocyte ratio with disease severity in patients with hyperlipidemic acute pancreatitis: A retrospective-cohort study

Journal of International Medical Research
Objective This study aimed to evaluate the correlations between the triglyceride glucose–body mass index, the bedside index for severity in acute pancreatitis score, and the C-reactive protein-to-lymphocyte ratio with disease severity, as well as their ...
Ruihua Xie, Yan Zhang
doaj   +1 more source