Results 51 to 60 of about 10,516,949 (236)

Evaluation of Triglyceride Glucose Index and Homeostasis Model of Insulin Resistance in Patients with Polycystic Ovary Syndrome

, 2022
Yitong Zheng,1,* Guoshu Yin,1,* Fu Chen,2 Ling Lin,3,4 Yongsong Chen1 1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shantou University Medical College, Shantou, People’s Republic of China; 2Department of Nutrition,
Zheng Y, Yin G, Chen F, Chen Y, Lin L
core  

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

Association of triglyceride-glucose index and triglyceride–glucose–body mass index with all-cause mortality in critically ill patients with aortic disease: A retrospective cohort study

JTCVS Open
Objective: Aortic diseases represent a group of life-threatening vascular disorders that impose a substantial socioeconomic burden. This study aimed to investigate the association between insulin resistance indices and all-cause mortality in with aortic ...
Jie Liu, MD, Zhaoxin Qian, MD, PhD, Jing Cao, MD, PhD   +2 more
doaj   +1 more source

Association between triglyceride glucose-body mass index and non-alcoholic fatty liver disease in the non-obese Chinese population with normal blood lipid levels: a secondary analysis based on a prospective cohort study

Lipids in Health and Disease, 2020
Background Both triglyceride glucose-body mass index (TyG-BMI) and non-alcoholic fatty liver disease (NAFLD) are linked to insulin resistance (IR). Prospective studies linking TyG-BMI to NAFLD have been limited by short follow-up. This study investigated
Yaling Li, Rui Zheng, Jie Li, Shuyi Feng, Li Wang, Zhiming Huang   +5 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Triglyceride Glucose‐Body Mass Index Is Related With Arterial Stiffness in Adults: A Cross‐Sectional Study

The Journal of Clinical Hypertension
ABSTRACT The triglyceride glucose‐body mass index (TyG‐BMI) has emerged as a unique indicator of insulin resistance (IR). This study aimed to investigate the relationship between the TyG‐BMI and arterial stiffness among 18,312 participants from Hebei General Hospital in China.
Li, Yang, Gao, Yan, Chen, Feifei, Wang, Zichang, Han, Yancong, Liang, Jiayi, Ma, Xiaowei   +6 more
openaire   +2 more sources

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Triglyceride Glucose Index Predicting Cardiovascular Mortality in Chinese Initiating Peritoneal Dialysis: A Cohort Study [PDF]

, 2019
Background:Insulin resistance (IR) is increased among people with end-stage renal disease (ESRD). The Triglyceride glucose (TyG) index is a marker of IR and is also associated with the prognosis of cardiovascular disease among patients initiating ...
Yu
core   +1 more source

The first-trimester triglyceride glucose-body mass index is a valuable predictor for adverse pregnancy outcomes

BMC Pregnancy and Childbirth
Although insulin resistance has been associated with unfavorable pregnancy outcomes, the ability of non-insulin-based insulin resistance indicators to predict adverse pregnancy outcomes has yet to be thoroughly understood. The study aims to investigate the association and predictability of triglyceride glucose-body mass index (TyG-BMI), a biomarker of ...
Zhaoran Meng, Minhuan Lin, Lizhu Song, Yiqing Chen, Songqing Deng, Shuting Xia, Xuewen Huang, Yanmin Luo   +7 more
openaire   +3 more sources

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source