Results 41 to 50 of about 10,516,949 (236)

J-shaped association of the triglyceride glucose-body mass index with new-onset diabetes

Scientific Reports
AbstractThe triglyceride glucose-body mass index (TyG-BMI) is a convenient and clinically significant indicator of insulin resistance. This study aims to investigate the correlation between TyG-BMI and the onset of new-onset diabetes and determine an optimal reflection point for TyG-BMI.
Qincheng Qiao, Kai Liang, Chuan Wang, Lingshu Wang, Fei Yan, Li Chen, Xinguo Hou   +6 more
openaire   +3 more sources

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Application value of triglyceride-glucose index and triglyceride-glucose body mass index in evaluating the degree of hepatic steatosis in non-alcoholic fatty liver disease

Lipids in Health and Disease, 2023
Abstract Background The elevation of TyG is considered an important factor in promoting the progression of non-alcoholic fatty liver disease (NAFLD), but its impact on the degree of liver steatosis remains unclear. This study aims to explore the relationship between TyG and TyG-related indices,
Mengyuan Wang, Mingxing Chang, Peipu Shen, Wei Wei, Huayao Li, Guifang Shen   +5 more
openaire   +3 more sources

Evaluation of the Triglyceride-Glucose Index with Different Generations of Beta-Adrenergic Blockers [PDF]

Background: Beta-blockers (β-blockers) work by blocking β-adrenergic receptors and differ in their metabolic effects and side effects. We aimed to compare the metabolic effects of different generations of β-blockers by evaluating the triglyceride-glucose
Atakan Arpaç, Fatma Nihan Turhan Çağlar, Cennet Yıldız, Demet Erciyes   +3 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Association of serum lipid levels, triglyceride–glucose index, systemic immune-inflammation index, and platelet-to-lymphocyte ratio with colorectal cancer: A retrospective study from China

Journal of International Medical Research
Objective This retrospective case–control study aimed to explore the correlations of blood lipid levels, triglyceride–glucose index, systemic immune-inflammation index, and platelet-to-lymphocyte ratio with colorectal cancer and evaluate their potential ...
Zhiwei Wang, Fanglai Zhu, Lu Dai
doaj   +1 more source

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index [PDF]

, 2011
Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain.
Paternoster, Lavinia, Freathy, R.M., Jefferis, B. J., Johnson, P.C.D., Watt, G., Munafò, M, Ebrahim, S, Tozzi, F., Lawlor, D. A., Johnson, PC, Tozzi, Federica, Watt, Graham, Ebrahim, Shah, Ring, SM, Kring, S., Jefferis, BJ, C. Holst, Mooser, V, Tozzi, F, Hattersley, Andrew T, V. Mooser, Sorensen, T.I.A., A. T. Hattersley, Sørensen, Thorkild IA, Vollenweider, Peter, Ring, S.M., Kazeem, Gbenga R, Freathy, RM, Freathy, Rachel M, Hattersley, AT, Johnson, Paul CD, S. M. Ring, Whincup, PH, Whincup, P.H., Preisig, M, Sattar, N., Munafò, Marcus, Johnson, Paul C D, Lawlor, Debbie A, A. Hill, Hingorani, A.D., Jefferis, B.J., Vollenweider, P., S. I. I. Kring, Davey Smith, George, F. Tozzi, Ebrahim, S., Mooser, V., G. Waeber, Whincup, P. H., Hill, A, Jefferis, Barbara J, Morris, R. W., Mooser, Vincent, Whincup, Peter H, P. C. D. Johnson, Frayling, T. M., Sattar, Naveed, B. J. Jefferis, Kazeem, GR, Holst, Claus, Preisig, Martin, Kring, SI, Freathy, R. M., Sorensen, T. I. A., Watt, G, Hill, A., Ring, S. M., Padmanabhan, S, Davey Smith, G., Frayling, TM, G. Davey Smith, Upton, Mark N, Paternoster, L., Morris, Richard W, Waeber, Gerard, S. Ebrahim, Kring, S.I., Kring, Sofia I I, Sattar, N, Kring, Sofia II, L. Paternoster, Sørensen, TI, Hingorani, AD, Upton, M.N., D. A. Lawlor, T. M. Frayling, Hattersley, A.T., Hingorani, A. D., Preisig, M., Hattersley, A. T., Padmanabhan, S., Sorensen, Thorkild, T. I. A. Sorensen, Holst, C., Lawlor, DA, Holst, C, Waeber, G, Hingorani, Aroon D, Frayling, T.M., Padmanabhan, Sandosh, Waeber, G., Lawlor, D.A., A. D. Hingorani, Morris, RW, Sørensen, T.I., P. Vollenweider, G. R. Kazeem, Kazeem, G. R., Johnson, P.C., S. Padmanabhan, Upton, M. N., P. H. Whincup, R. W. Morris, Upton, MN, N. Sattar, Vollenweider, P, Ring, Susan M, Davey Smith, G, R. M. Freathy, M. Munafo, Sørensen, Thorkild I A, Munafo, M., Johnson, P. C. D., G. Watt, M. Preisig, Kazeem, G.R., Kring, S. I. I., Hill, Anita, Frayling, Timothy M, M. N. Upton, Paternoster, L, Kazeem, G.B., Morris, R.W.   +133 more
core   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Correlation between triglyceride glucose-body mass index and hypertension risk: evidence from a cross-sectional study with 60,283 adults in eastern China

BMC Cardiovascular Disorders
Background Insulin resistance (IR) and obesity are established risk factors for hypertension, with triglyceride-glucose (TyG) serving as a recognized surrogate marker for IR.
Yijia Chen, Jinling Du, Nan Zhou, Yingqian Song, Weiwei Wang, Xin Hong   +5 more
doaj   +1 more source