Results 61 to 70 of about 5,723,129 (297)

Additional file 3 of Association between triglyceride glucose index and sleep disorders: results from the NHANES 2005–2008

, 2023
Additional file 3: e_table.3.
Shouling Wu (388386), Yangyang Lu (1650511), Heng Pei (15281393), Shuyu Li (18735), Xin Su (338394), Zhijun Wang (31218)   +5 more
core   +1 more source

A Novel 3D Model Co‐Culturing Breast Cancer Cells in Direct Contact with Patient‐Derived Mature Adipocytes Demonstrates Cell‐Type Specific Alterations in Phenotype and Chemosensitivity

Advanced Healthcare Materials, EarlyView.
A novel 3D GelMA co‐culture model enabled sustained direct contact between patient‐derived mature adipocytes and breast cancer cells, revealing subtype‐specific interactions. MDA‐MB‐231 co‐culture caused adipocyte perilipin‐1 loss and reduced chemotherapy responsiveness, while MCF7 cells showed partial epithelial‐mesenchymal transition; both cell lines
Jessika A. Wise, Margaret J. Currie, Helen R. Morrin, Gretel S. Major, Tim B. F. Woodfield, Khoon S. Lim, Elisabeth Phillips   +6 more
wiley   +1 more source

Comparison of Triglyceride-Glucose Index Indices and Fatty Liver Index in Predicting Metabolic Dysfunction-Associated Fatty Liver Disease: A Cross-Sectional Study Conducted in Vietnam

Life
Background and Aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly prevalent and linked to liver and cardiometabolic complications. Although liver biopsy remains the diagnostic gold standard, its invasiveness limits routine
Linh Nhat Boi Nguyen, Thong Duy Vo
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Association between triglyceride–glucose–related indices and all-cause and cause-specific mortality among individuals with periodontitis: A population-based study

Journal of International Medical Research
Objective This study aimed to investigate the associations of triglyceride–glucose–related indices with all-cause, cardiovascular disease–related, and cancer-related mortality in US adults with periodontitis.
Dongdong Cen, Zhe Wang, Negin Toufani, Tian Li, Shanfeng Lin   +4 more
doaj   +1 more source

Discriminative Capacity of Visceral Adiposity and Triglyceride Glucose-Waist Circumference Indices for Metabolic Syndrome in Spanish Adolescents: A Cross-Sectional Study

Metabolites
Background/Objectives: Adolescence is a critical period for the early detection of metabolic syndrome (MetS), a condition that increases the risk of cardiometabolic diseases in adulthood.
Ángel Fernández-Aparicio, Miriam Mohatar-Barba, Javier S. Perona, Jacqueline Schmidt-RioValle, Carmen Flores Navarro-Pérez, Emilio González-Jiménez   +5 more
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Enhanced prediction of cholecystectomy using obesity-modified TyG indices: a machine learning and SHAP-based study

European Journal of Medical Research
Background This study investigates the association between TyG-related composite indices and the risk of gallstones and the history of cholecystectomy, using logistic regression and machine learning models to evaluate predictive performance and clinical ...
Yue Zhang, Ruifeng Duan, Xin Chen, Lijuan Wei   +3 more
doaj   +1 more source

Triglyceride-Glucose Index in the Prediction of Prediabetes

Revista Eugenio Espejo
Prediabetes is a metabolic disorder characterized by insulin resistance long before the diagnosis of type 2 diabetes mellitus (T2DM) and represents a key opportunity for intervention and prevention of T2DM. The triglyceride-glucose index (TGI) has been identified as an accessible marker of insulin resistance with potential diagnostic value.
Jorman Francisco Choez Alava, Marja Morales Baldeon, Carmen Vanessa Vaca Vera, Bertha Carolina Cruz Murillo   +3 more
openaire   +1 more source