Results 61 to 70 of about 4,380,453 (298)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

The correct formula for the triglycerides and glucose index [PDF]

European Journal of Pediatrics, 2020
Luis E, Simental-Mendía, Fernando, Guerrero-Romero   +1 more
openaire   +2 more sources

The Triglyceride-Glucose Index: A Cost-Effective Biomarker for Early Detection of Insulin Resistance in Autosomal Dominant Polycystic Kidney Disease [PDF]

Objective: Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary cause of end-stage renal disease, often associated with metabolic disorders, including insulin resistance and diabetes mellitus (DM).
DEĞER, SERPİL MÜGE, KORUCU, BERFU, HEYBELİ, CİHAN, Serpil Müge DEĞER, DELİGÖZ BİLDACI, YELDA, Cihan HEYBELİ, Doğan Can GAVCAR, Atay, İlker, Caner ÇAVDAR, Berfu KORUCU, OKTAN, MEHMET ASI, Gavcar, Doğan Can, Mehmet Ası OKTAN, ÇAVDAR, CANER, Yelda DELİGÖZ BİLDACI, İlker ATAY   +15 more
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Triglyceride-glucose index as a criterion for the steatosis of the liver

Bukovinian Medical Herald, 2023
За даними сучасної наукової літератури, високий рівень тригліцеридоглюкозного індексу (ТГГІ) асоційований з метаболічно-асоційованою жировою хворобою печінки, однак рівень та діагностичне значення його у пацієнтів з метаболічно-асоційованим стеатозом печінки (МАСП) без стеатогепатиту не визначені.
openaire   +3 more sources

Association of novel triglyceride-glucose index-derived indices with hyperuricemia among oilfield workers

Frontiers in Nutrition
ObjectivesThe association and predictive value of newer triglyceride-glucose (TyG)-derived anthropometric indices for hyperuricemia have not been systematically evaluated.MethodsLogistic regression, restricted cubic spline (RCS) modeling, subgroup ...
Haobiao Liu, Haobiao Liu, Qingsong Li, Husna Wali, Yingjie Cai, Jing Tang, Licheng Yang, Xuefeng Yu, Jinsong Li, Bowei Yang, Ziwei Guo, Jing Han, Zhiyong Du   +12 more
doaj   +1 more source

Predictive Effect of Triglyceride-Glucose Index on Adverse Prognostic Events in Patients with Type 2 Diabetes Mellitus and Ischemic Cardiomyopathy

, 2023
Baiheremujiang Abuduaini,1,* Long Yang,2,* Nueraihemaiti Jiamali,1 Zulihuma Seyiti,2 Xue-Feng Shan,3– 5 Xiao-Ming Gao4– 6 1First Clinical Medical College, Xinjiang Medical University, Urumqi, People’s Republic of China; 2College of Pediatrics ...
Gao XM, Yang L, Jiamali N, Shan XF, Seyiti Z, Abuduaini B   +5 more
core  

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source