Results 81 to 90 of about 5,723,129 (297)

Triglyceride-glucose index as a criterion for the steatosis of the liver

Bukovinian Medical Herald, 2023
За даними сучасної наукової літератури, високий рівень тригліцеридоглюкозного індексу (ТГГІ) асоційований з метаболічно-асоційованою жировою хворобою печінки, однак рівень та діагностичне значення його у пацієнтів з метаболічно-асоційованим стеатозом печінки (МАСП) без стеатогепатиту не визначені.
openaire   +3 more sources

Association between triglyceride glucose-body mass index and all-cause mortality in patients with sepsis: Evidence from a retrospective cohort study

Journal of International Medical Research
Background Sepsis remains a leading cause of mortality in critically ill patients, necessitating the identification of reliable prognostic markers. The triglyceride glucose-body mass index, which combines lipid and glucose metabolism, may serve as a ...
Yufan Pu, Xiang Zhou, Xuejing Li, Jiang Xu   +3 more
doaj   +1 more source

Predictive Effect of Triglyceride-Glucose Index on Adverse Prognostic Events in Patients with Type 2 Diabetes Mellitus and Ischemic Cardiomyopathy

, 2023
Baiheremujiang Abuduaini,1,* Long Yang,2,* Nueraihemaiti Jiamali,1 Zulihuma Seyiti,2 Xue-Feng Shan,3– 5 Xiao-Ming Gao4– 6 1First Clinical Medical College, Xinjiang Medical University, Urumqi, People’s Republic of China; 2College of Pediatrics ...
Gao XM, Yang L, Jiamali N, Shan XF, Seyiti Z, Abuduaini B   +5 more
core  

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Adiposity indicators lipid accumulation product and triglyceride-glucose index as alternate criteria for the diagnosis of metabolic obesity in adult

Bangabandhu Sheikh Mujib Medical University Journal, 2018
Metabolic obesity refers to the state of having metabolic syndrome irrespective of one’s body mass index. This study was aimed to elucidate the lipid accumulation product and triglyceride-glucose index as simple and alternate criteria for detecting ...
Mariya Tabassum, Md. Matiur Rahman, Miliva Mozaffor   +2 more
doaj   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Association of novel triglyceride-glucose index-derived indices with hyperuricemia among oilfield workers

Frontiers in Nutrition
ObjectivesThe association and predictive value of newer triglyceride-glucose (TyG)-derived anthropometric indices for hyperuricemia have not been systematically evaluated.MethodsLogistic regression, restricted cubic spline (RCS) modeling, subgroup ...
Haobiao Liu, Haobiao Liu, Qingsong Li, Husna Wali, Yingjie Cai, Jing Tang, Licheng Yang, Xuefeng Yu, Jinsong Li, Bowei Yang, Ziwei Guo, Jing Han, Zhiyong Du   +12 more
doaj   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source