Results 101 to 110 of about 5,723,129 (297)

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria [PDF]

Hua Hao, Hui Geng, Mao Ma Physical Examination Center, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Mao Ma, Email mamaoxj@163.comObjective: To explore the association between ...
Geng H, Ma M, Hao H
core  

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

The triglyceride glucose index and cardiovascular disease outcomes

The Lancet Healthy Longevity, 2023
David, Flood, Luisa Campos Caldeira, Brant, Jeremy B, Sussman   +2 more
openaire   +2 more sources

Proportion of sows with glucose intolerance according to the classification of the triglyceride and glucose index calculated using glycemia from the HGI (A) and blood glucose concentrations measured by the glucometer (B) per group and reproductive phase.

, 2022
Proportion of sows with glucose intolerance according to the classification of the triglyceride and glucose index calculated using glycemia from the HGI (A) and blood glucose concentrations measured by the glucometer (B) per group and reproductive phase.
Gerardo Ordaz (12506057), Ruy Ortiz (12506060), Cyntia Michelle González (12506051), Manuel López (3404696), Rosa Elena Pérez (12506048), Katya Vargas (12506054)   +5 more
core   +1 more source

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Prognostic value of the triglyceride–glucose index in patients with acute ischemic stroke undergoing endovascular treatment

Journal of International Medical Research
Objective This study aimed to assess the prognostic significance of the triglyceride–glucose index in predicting clinical outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy.
Ke Yang, Qiwu Xu, Xiangxiang Peng, Xiangjun Xu, Yapeng Guo, Junfeng Xu   +5 more
doaj   +1 more source

Triglyceride-glucose–body mass index as an integrated marker for ultrasound-defined diastolic dysfunction: variable importance via machine learning and SHAP analysis in a Chinese community cohort

Frontiers in Cardiovascular Medicine
IntroductionThe triglyceride-glucose–body mass index, which integrates the triglyceride-glucose index with body mass index, has emerged as a promising marker of metabolic risk for heart failure with preserved ejection fraction; however, its association ...
Pengcheng Li, Jing Bai, Jirui Cai, Jingyi Zhang, Zhiwei Huang, Jin Wang, Bing He, Qiaotao Xie, Haoran Wang   +8 more
doaj   +1 more source

The Role of Triglyceride-Glucose Index in Central Retinal Artery Occlusion

International Ophthalmology
Abstract Purpose:To evaluate the correlation between the Triglyceride-Glucose (TyG) index and newly diagnosed cases of central retinal artery occlusion (CRAO) in patients. Methods: The research involved 51 patients diagnosed with central retinal artery occlusion (CRAO) and a control group consisting of 50 healthy volunteers matched for age and ...
Hatice Aslan Sirakaya, Bekir Ayyildiz, Ibrahim Ismet Sert, Bekir Kucuk, Semra Koca, Ender Sirakaya   +5 more
openaire   +2 more sources