Results 31 to 40 of about 295,120 (258)

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Differences in DBA/1J and DBA/2J reveal lipid QTL geness⃞

Journal of Lipid Research, 2008
Recent advances in mouse genomics have revealed considerable variation in the form of single-nucleotide polymorphisms (SNPs) among common inbred strains. This has made it possible to characterize closely related strains and to identify genes that differ;
Ioannis M. Stylianou, Sarah R. Langley, Kenneth Walsh, Yuan Chen, Céline Revenu, Beverly Paigen   +5 more
doaj   +1 more source

Statistical Analysis of Lipid Profiles Associated with Coronary Heart Disease in Erbil City-Iraq

Polytechnic Journal, 2023
Background and objectives: Coronary heart disease (CHD) is one of the most prevalent diseases worldwide. The primary risk factor for coronary heart disease (CHD) lies in the presence of hypertension, elevated levels of triglycerides (TG), total ...
Dler Hussein Kadir, Karzan Abdullah, Aziz Muazafar Jafaar, Rebaz Hamza Salih, Shukur Wasman Smail, Gashaw Qasim Rahman, Harem Khdir Awla, Zhikal Omar Khudhur   +7 more
doaj   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Improved lipid profile through liver-specific knockdown of liver X receptor α in KKAy diabetic mice

Journal of Lipid Research, 2009
Nuclear hormone receptors liver X receptor (LXRα and LXRβ) ligands are attractive approaches for the treatment of dyslipidemia and atherosclerosis. To further elucidate the function of LXRα in liver lipid metabolism in a disease-relevant animal model ...
Joerg F. Rippmann, Corinna Schoelch, Thomas Nolte, Heidi Pavliska, André van Marle, Helmuth van Es, Juergen Prestle   +6 more
doaj   +1 more source

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Elevated Triglycerides (≥150 mg/dL) and High Triglycerides (200–499 mg/dL) Are Significant Predictors of New Heart Failure Diagnosis: A Real-World Analysis of High-Risk Statin-Treated Patients

Vascular Health and Risk Management, 2019
Peter P Toth,1,2 Sephy Philip,3 Michael Hull,4 Craig Granowitz3 1CGH Medical Center, Sterling, IL, USA; 2Johns Hopkins University School of Medicine, Baltimore, MD, USA; 3Amarin Pharma Inc, Bedminster, NJ, USA; 4Optum, Eden Prairie, MN, USACorrespondence:
Toth PP, Philip S, Hull M, Granowitz C
doaj  

The Alcohol–High-Density Lipoprotein Athero-Protective Axis

Biomolecules, 2020
Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an ...
Corina Rosales, Baiba K. Gillard, Antonio M. Gotto, Henry J. Pownall   +3 more
doaj   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source