Results 111 to 120 of about 62,174 (256)

利用三碘甲狀腺氨酸強化療法治療對於三環抗抑鬱藥物無效的濫用藥物病人 [PDF]

, 2001
We report on two substance misusers with depression resistant to tricyclic antidepressant treatment who responded to triiodothyronine augmentation.
Ho, TP, Kan, CK
core  

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Association Between Thyroid-Stimulating Hormone and Estimated Glomerular Filtration Rate in the Third Trimester of Pregnancy: A Retrospective Cross-Sectional Study in Euthyroid Women

Medicina
Background and Objectives: This study investigated the relationship between thyroid function and renal parameters during the third trimester of pregnancy in euthyroid women, a physiological interaction that remains poorly characterized.
Canan Satır Özel, Yaşar Sertbaş, Şeyma Taştekin, Asya Tancer Özçelik, Meltem Sertbaş, Özge Kınlı Yıldız, Abdulkadir Turgut   +6 more
doaj   +1 more source

Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease

The Journal of Physiology, EarlyView.
Abstract figure legend This review utilized animal models of complicated human pregnancies that result in reduced fetal nutrient or oxygen delivery, or combined nutrient and oxygen delivery, to elucidate their independent and/or synergistic contributions to the development of high‐risk cardiac phenotypes.
Melanie R. Bertossa, Jack R. T. Darby, Ashley S. Meakin, Mitchell C. Lock, Steven K. S. Cho, Christopher K. Macgowan, Mike. Seed, Michael D. Wiese, Janna L. Morrison   +8 more
wiley   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Determination of the kidney injury in multiple myeloma according to the KDIGO 2012 acute kidney injury guideline and relationship between serum β2 microglobulin and free T3 levels and acute kidney injury

Medicine Science
Renal failure is common in multiple myeloma (MM) and is one of the main causes of morbidity and mortality. Despite many advances in diagnosis and treatment, almost half of the patients present with renal failure at presentation. In our study, we aimed to
Sercan Kiremitci, Suleyman Bas, Okan Akyuz, Funda Muserref Turkmen   +3 more
doaj   +1 more source

Graves' Disease: Prospective Up to 10‐Year Outcome for 100 Consecutive Individuals at a Single Centre

Clinical Endocrinology, EarlyView.
Muhammad Muneeb Ibad, Mrinalini Srichandran, Sangeeth Veluchamy, Waseem Majeed, Natalie Gallant, Sarah Jamil, Rupinder Kochhar, Suhani Bahl, Lakdasa Premawardhana, Peter Taylor, Onyebuchi Okosieme, Colin Dayan, Adrian Heald   +12 more
wiley   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, Volume 13, Issue 25, 4 May 2026.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source