Results 41 to 50 of about 67,879 (252)

The Value of Comparative Animal Research : Krogh’s Principle Facilitates Scientific Discoveries [PDF]

open access: yes, 2017
There are no conflicts of interest to declare. This paper developed from the 2016 Early Career Impact Award from the Federation of Associations in Behavioral & Brain Sciences to TJS. TJS has received funding from The Leverhulme Trust.
Alward, Beau A.   +5 more
core   +2 more sources

Molecular Actions of Thyroid Hormone on Breast Cancer Cell Migration and Invasion via Cortactin/N-WASP

open access: yesFrontiers in Endocrinology, 2019
The thyroid hormone triiodothyronine (T3) plays a fundamental role in growth regulation, differentiation, metabolism and cellular movement. These processes are particularly important considering that deregulation of T3 levels could promote abnormal ...
Ivonne Denise Uzair   +4 more
doaj   +1 more source

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC

open access: yesAdvanced Science, EarlyView.
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng   +6 more
wiley   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

open access: yesAdvanced Science, EarlyView.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei   +8 more
wiley   +1 more source

Effect Of Organic Selenium And Iodine Supplementation On Selenium And Thyroid Hormones Status Of Lactating Ewes And Lambs

open access: yesActa Veterinaria, 2015
The aim of this research was to determine the influence of 56-days (from day 4 to day 60 post partum) of simultaneous supplementation of selenium (Se) and iodine (I) enriched Chlorella algae on blood and urine Se concentrations and thyroid hormone levels
Konečný Roman   +5 more
doaj   +1 more source

Associations of Blood Analysis with Feed Efficiency and Developmental Stage in Grass-Fed Beef Heifers

open access: yesAnimals, 2018
Proxies for feed efficiency, such as blood-based indicators, applicable across heifers varying in genetic makeup and developmental state are needed. Assessments of blood analytes and performance were made in heifer calves and pregnant heifers.
Nara R. B. Cônsolo   +6 more
doaj   +1 more source

Changes in serum thyroid hormone levels in psychiatric patients treated with second-generation antipsychotics

open access: yesEndokrynologia Polska, 2020
INTRODUCTION: The objective of the study was to evaluate changes in serum thyroid hormone levels in psychiatric patients after second-generation antipsychotic (SGA) treatment, and to determine differences between monotherapy and polytherapy with SGAs, as
Jia-Xuan Zhang, Xun Li
doaj   +1 more source

Effects of dietary triiodothyronine or dopamine on small intestinal oxygen consumption in chicks

open access: yesChinese Journal of Physiology, 2022
This study aimed to investigate the effects of triiodothyronine (T3)- or dopamine (Dp)-supplemented diets on oxygen consumption by Na+, K+-ATPase activity in broiler chicks.
Shen-Chang Chang   +3 more
doaj   +1 more source

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

open access: yesAdvanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang   +13 more
wiley   +1 more source

Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]

open access: yes, 2015
The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Farjo, Bessam   +4 more
core   +9 more sources

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