Results 101 to 110 of about 454,552 (336)
Tumor Biology, 2017 Osteosarcoma is one of the most lethal malignancies, and the prognosis remains dismal due to the paucity of effective therapeutic targets. Bmi-1 and TRIM-14 are associated with the initiation and progression of osteosarcoma, which could promote ...
Gui-Hua Yu +4 more
doaj +1 more source
How the market driving approach can create brand value through a digital platform. [PDF]
, 2017 This paper examines how the value of a brand is enhanced through a learning process that incorporates customer dialogue and results in co-creation and the incorporation of a consumer oriented relationship marketing approach. We adopted the market driving
Lee, Yang-im +3 more
core
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Applied SciencesOne of the promising strategies for the improvement of the resistance characteristics and energy efficiency of a ship is trim optimization. Most of the studies conducted so far regarding trim optimization deal with unrestricted water.
Ivana Martić +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Analisa Pengaruh Trim terhadap Konsumsi Bahan Bakar
Jurnal Teknik ITS, 2013 Trim merupakan salah satu kondisi pada kapal dimana terdapat perbedaan draft pada bagian haluan dan buritan. Kapal bergerak dengan kecepatan dinasnya (Vs) pada kondisi normal continuous rating.Pada tahap pendesainan kapal tahanan total kapal (Rt ...
Nur Salim Salim Aris +2 more
doaj
Micromachines, 2018 Heat dissipation has become an important issue due to the miniaturization of various electronic devices. Various methods such as spray and nozzle coolers, heat sinks and so on are used for heat dissipation.
Jae-Hee Kim +2 more
doaj +1 more source
Tank Tests of Models of Floats for Single-float Seaplanes First Series. [PDF]
Large models of the Mark V and Mark VI floats used for single float seaplanes (National Advisory Committee for Aeronautics (NACA) models 41-A and 41-B, respectively) were tested in the NACA tank to provide general test data for typical single floats and ...
Parkinson, J B
core +1 more source
TRIMming Flavivirus Infection [PDF]
Cell Host & Microbe, 2011 Tripartite motif (TRIM) proteins are novel players in antiviral innate immunity. In this issue of Cell Host & Microbe,Taylor et al. (2011) discover the mechanism of action of TRIM79α and show that this interferon-induced protein restricts tick-borne flaviviruses by targeting the viral polymerase for degradation.
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source