Results 121 to 130 of about 454,552 (336)
К биографии Асандра: путь к престолу / To the biography of Asander: way to the throne
Материалы по археологии и истории античного и средневекового Крыма, 2014 Трудно найти более яркую личность на боспорском троне, чем Асандр. Родившись простым гражданином, он не только смог оттеснить на время от престола законный дом Митридатидов, но и навязал свою волю всевластному Риму.
Чореф М.М. / Choref M.M.
doaj
French political symbolism and identity construction
Russian Journal of LinguisticsThe present study examines how the language of political symbolism operates within the framework of identity construction. It focusses on the themes of sovereignty during the 2022 French presidency of the European Union and the national presidential ...
Richard Trim
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Reflecting on Social Inclusion Through Philosophical Discussion: A Sustainable Partnership Framework
ChallengesThe 17 sustainable development goals advocated by the United Nations have played a big role in focusing the minds of policy makers in terms of sustainability issues and have also highlighted the issue of social inclusion and the need to make society more
Peter R. J. Trim, Richard C. L. Trim
doaj +1 more source
Theory and Practice of Logic ProgrammingAbstractVariable sharing is a fundamental property in the static analysis of logic programs, since it is instrumental for ensuring correctness and increasing precision while inferring many useful program properties. Such properties include modes, determinacy, non-failure, cost, etc.
DANIEL JURJO-RIVAS +3 more
openaire +3 more sources
TRIM proteins as trim tabs for the homoeostasis [PDF]
Journal of Biochemistry, 2013 The tripartite motif (TRIM) or RBCC proteins are characterized by the TRIM composed of a RING finger, B-box and coiled-coil domains. TRIM proteins often play roles in the post-translational protein modification, including ubiquitylation and other ubiquitin-like modifications.
openaire +2 more sources
Target-induced clustering activates Trim-Away of pathogens and proteins
Nature Structural & Molecular Biology, 2021 Jingwei Zeng +15 more
semanticscholar +1 more source
Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer?
International Journal of Molecular Sciences, 2019 Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated, but the huge heterogeneity of these diseases, to be intended both inter- and intra-tumour, makes it a hard-to-win battle.
A. Valletti +4 more
semanticscholar +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source