Results 131 to 140 of about 454,552 (336)
Tank Tests of Model 11-G Flying-boat Hull [PDF]
The NACA model 11-G flying-boat hull, a modification of NACA model 11-A was tested over a range of loadings. The planing bottom of model 11-G has a variable-radius flare, or concavity, at the chines in contrast to the straight V planing bottom of model ...
Parkinson, J B
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity
Life Science Alliance, 2019 This study shows that members of the class VI TRIM E3 ligase family contain monomeric RING domains and display no ligase activity and may require additional regulatory events to promote ubiquitination. TRIM E3 ubiquitin ligases regulate multiple cellular
R. V. Stevens, D. Esposito, K. Rittinger
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FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Study of several factors affecting crew escape trajectories from the Space Shuttle Orbiter at low-subsonic speeds [PDF]
Factors affecting the bailout characteristics from the space shuttle orbiter at low-subsonic speeds were investigated. In the 12-foot low-speed tunnel and the 4 by 7-meter tunnel with 0.03-scale models.
Applin, Z. T. +7 more
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Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
Journal of Marine Science and EngineeringTrim optimization is an available approach for the energy saving and emission reduction of a ship. As a ship sails on the water, the draft and trim undergo constant changes due to the consumption of fuel oil and other consumables.
Yanyun Yu +5 more
doaj +1 more source
Algorithms for aircraft trim analysis on ground 13; AIAA-96-350513; [PDF]
, 1996 In the analysis of aircraft dynamics far up and13; away flight, the general practice consists of trimming13; the aircraft for a specific maneuvers at a specified13; Altitude and Mach number.
Pashilkar, AA
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