Results 61 to 70 of about 381,907 (293)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Exploration of the TRIM fold of MuRF1 using EPR reveals a canonical antiparallel structure and extended COS-box [PDF]

, 2019
MuRF1 (TRIM63) is a RING-type E3 ubiquitin ligase with a predicted tripartite TRIM fold. TRIM proteins rely upon the correct placement of an N-terminal RING domain, with respect to C-terminal, specific substrate-binding domains.
Cafiso, David S., Franke, Barbara, Mayans, Olga, Norman, David G., Pornillos, Owen, Skorupka, Katarzyna A., Stevens, Michael   +6 more
core   +3 more sources

Trimming swept volumes

Computer-Aided Design, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Blackmore, Denis, Samulyak, Roman, Leu, Ming C.   +2 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

TRIM

, 2018
Este projeto foi realizado na especialização de Design de Som e tem como principal foco o campo da composição e performance musical utilizando o computador como ferramenta central em ambos os campos. Para esse efeito o computador assume a função de instrumento, sendo o editor de som e o DAW1 as principais ferramentas de composição e performance com ...
openaire   +3 more sources

The Second Trim Correction in Draught Survey Procedure – Accuracy Analysis [PDF]

TransNav
The basic method for determining the mass of dry bulk cargo, loaded on the ship or unloaded from the ship, is the Draught Survey procedure. This procedure is quite simple, however is highly susceptible to mistakes and accidental errors.
Wojciech Wawrzynski
doaj   +1 more source

The Uses of Adversity: Matthew Flinders' Mauritius Writings [PDF]

, 2002
A discussion of Matthew Flinders' 'Biographical Tribute to the Memory of Trim' and of an extended journal entry, both written while he was detained on ...
Dooley, Gillian Mary
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Research on flight simulation repositioning algorithm and its application

Hangkong gongcheng jinzhan
In the application of flight simulator, it is required that the aircraft simulation model quickly relocates to a specific state according to the training subject requirements, so it is crucial to quickly obtain the initial state parameter values of the ...
WU Yuanhang, ZHANG Qiang, SHEN Ce
doaj   +1 more source