Results 221 to 230 of about 209,912 (265)

Characterisation of post-translational and transcriptional reprogramming of the immune response to ISAV and IPNV infections in salmon head kidney cells. [PDF]

open access: yesFront Immunol
Stewart R   +8 more
europepmc   +1 more source

Ubiquitin E3 Ligases and p53 in Doxorubicin-Induced Cardiotoxicity. [PDF]

open access: yesInt J Mol Sci
Tachibana S   +4 more
europepmc   +1 more source
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M1-aminopeptidase family — beyond antigen-trimming activities

Current Opinion in Immunology, 2023
Antigen (Ag)-trimming aminopeptidases belong to the oxytocinase subfamily of M1 metallopeptidases. In humans, this subfamily contains the endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) and the insulin-responsive aminopeptidase (IRAP, synonym oxytocinase), an endosomal enzyme. The ability of these enzymes to trim antigenic precursors and to
Irini Evnouchidou   +3 more
openaire   +2 more sources

Emerging Role of TRIM Family Proteins in Cardiovascular Disease

Cardiology, 2020
Ubiquitination is one of the basic mechanisms of cell protein homeostasis and degradation and is accomplished by 3 enzymes, E1, E2, and E3. Tripartite motif-containing proteins (TRIMs) constitute the largest subfamily of RING E3 ligases, with >70 current members in humans and mice.
Jing-Rui, Zhang   +3 more
openaire   +2 more sources

TRIM family proteins: retroviral restriction and antiviral defence

Nature Reviews Microbiology, 2005
Members of the tripartite motif (TRIM) protein family are involved in various cellular processes, including cell proliferation, differentiation, development, oncogenesis and apoptosis. Some TRIM proteins display antiviral properties, targeting retroviruses in particular. The potential activity of TRIM19, better known as promyelocytic leukaemia protein,
Sébastien, Nisole   +2 more
openaire   +2 more sources

The interplay between viruses and TRIM family proteins

Reviews in Medical Virology, 2019
SummaryNovel therapeutic options are urgently needed to improve the global treatment of viral infections. Tripartite motif (TRIM) family proteins are involved in various biological and cellular functions including differentiation, development, proliferation, oncogenesis, innate immunity, and viral autophagy.
Ramisha Khan   +3 more
openaire   +2 more sources

Role of the tripartite motif (TRIM) family in female genital neoplasms

Pathology - Research and Practice, 2023
The tripartite motif proteins (TRIMs) family represents a class of highly conservative proteins which play a large regulatory role in molecular processes. Recently, increasing evidence has demonstrated a role of TRIMs in female genital neoplasms. Our review thereby aimed to provide an overview of the biological involvement of TRIMs in female genital ...
Tianyu Liu   +7 more
openaire   +2 more sources

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