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The role of TRIM family proteins in autophagy, pyroptosis, and diabetes mellitus
Cell Biology International, 2021AbstractThe ubiquitin‐proteasome system, which is one of the systems for cell protein homeostasis and degradation, happens through the ordered and coordinated action of three types of enzymes, E1 ubiquitin‐activating enzyme, E2 ubiquitin‐carrier enzyme, E3 ubiquitin‐protein ligase.
Tingting Wan, Xiudan Li, Yanbo Li
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Tumor suppressor p53 and TRIM family proteins
Cancer Cell & Microenvironment, 2015Tumor suppressor p53 plays a key role in maintaining genomic stability and tumor suppression. As a transcription factor, p53 mainly exerts its function in tumor suppression through transcriptional regulation of its target genes to regulate a wide variety of cellular responses. To maintain its proper function, p53 protein levels and activity are tightly
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TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis
Trends in Biochemical Sciences, 2017Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have various functions in cellular processes including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy, and carcinogenesis.
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Genomics and Evolution of the TRIM Gene Family
2012The TRIM family comprises proteins characterized by the presence of thetripartite motifthat is composed of a RING domain, one or two B-box domains and a Coiled-coil region. These proteins are implicated in a plethora of cellular processes such as apoptosis, cell cycle regulation, muscular physiology and innate immune response.
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Structural characterization of TRIM family proteins
2018TRIM proteins are E3 ubiquitin ligases that participate in many cellular processes and signaling pathways, such as immune system response. Several TRIM proteins were shown to form antiparallel coiled-coil dimers which position catalytic RING domains on the opposite sides of an elongated rod. As RING dimerization is necessary for its enzymatic activity,
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Inhibition of Retroviral Replication by Members of the TRIM Protein Family
2013The TRIM protein family is emerging as a central component of mammalian antiviral innate immunity. Beginning with the identification of TRIM5α as a mammalian post-entry restriction factor against retroviruses, to the repeated observation that many TRIMs ubiquitinate and regulate signaling pathways, the past decade has witnessed an intense research ...
Adam J, Fletcher, Greg J, Towers
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A Family of Compact Trim-Free CMOS Nano-Ampere Current References
2019 IEEE International Symposium on Circuits and Systems (ISCAS), 2019This paper introduces a family of three resistor-less low-power, low-area and trim-free current references with low PVT sensitivity. The proposed current sources achieve tens of nano-Ampere current consumption with a temperature coefficient down to 182ppm/°C.
Joan Santamaria +4 more
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Regulation of NLRP3/TRIM family signaling in gut inflammation and colorectal cancer
Biochimica et Biophysica Acta (BBA) - Reviews on CancerCRC (Colorectal cancer) ranks among the most prevalent tumors in humans and remains a leading cause of cancer-related mortality worldwide. Numerous studies have highlighted the connection between inflammasome over-activation and the initiation and progression of CRC.
Bibhashee, Mohapatra +3 more
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A Family of Scale Estimators by Means of Trimming
2004A very common practice in literature is that of building scale estimators by means of a location estimator. The most common scale estimator used is the standard deviation, which is obtained by using the mean; its use is not the most suitable one due to its weakness under the presence of outliers.
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