Results 101 to 110 of about 12,230 (281)
Central Beneficial Effects of Trimetazidine on Psychomotor Performance in Normal Healthy Volunteers
Advanced Biomedical Research, 2017 Background: Trimetazidine is a fatty oxidation inhibitor, leading to shifting of energy substrate from fatty acid oxidation toward glucose oxidation that leads to the reduction of oxygen requirement.
Hayder M Al-Kuraishy, Ali I Al-Gareeb
doaj +1 more source
Modulating the metabolism by trimetazidine enhances myoblast differentiation and promotes myogenesis in cachectic tumor-bearing c26 mice. [PDF]
, 2017 Trimetazidine (TMZ) is a metabolic reprogramming agent able to partially inhibit mitochondrial free fatty acid β-oxidation while enhancing glucose oxidation.
Chiandotto, S +8 more
core +3 more sources
Defining Treatment‐Resistant Bipolar Depression: Recommendations From the ISBD Task Force
Bipolar Disorders, Volume 27, Issue 6, Page 411-423, September 2025.ABSTRACT Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking.
Eduard Vieta +29 more
wiley +1 more source
Drug Testing and Analysis, Volume 17, Issue 8, Page 1417-1442, August 2025.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Health Science Reports, Volume 8, Issue 7, July 2025.ABSTRACT Background and Aims Right‐side heart failure (RSHF) jeopardizes left ventricular assist device (LVAD) short‐ and long‐term outcomes. The model for end‐stage liver disease (MELD) score is an effective means of evaluating liver dysfunction. This study aims to investigate the predictive utility of preoperative MELD on post‐LVAD implantation ...
Mohamed Elbayomi +4 more
wiley +1 more source
MODERN PECULIARITIES OF MYOCARDIAL CYTOPROTECTION IN THERAPY OF ISHEMIC HEART DISEASE PATIENTS
Медицинский совет, 2016 Results of meta-analysis of more than 20 clinical studies of use of various dosages and schemes of indication of trimetazidine to stable ischemic heart disease patients allowed considering the daily dosage of trimetazidine 70 mg as a standard therapeutic
Z. M. SIZOVA, S .K. VLADIMIROV
doaj +1 more source
A network meta-analysis comparing perioperative outcomes of interventions aiming to decrease ischemia reperfusion injury during elective liver resection [PDF]
, 2016 OBJECTIVE: This study sought to compare the perioperative outcomes of interventions aiming to decrease ischemia-reperfusion (IR) injury during elective liver resection.
Afxentiou, T +4 more
core +1 more source
Advanced Science, Volume 12, Issue 23, June 20, 2025.In the tumor margin of hepatocellular carcinoma (HCC), activated hepatic stellate cells upregulate MTFR2, initiating inhibiting DRP1 degradation and mitochondrial fission. This enhances mitochondrial availability and facilitates FAs synthesis via ACC1. Additionally, fission promotes RAC1‐mediated cytoskeletal remodeling and Miro1‐mediated mitochondrial
La Zhang +9 more
wiley +1 more source
MEMBRANE-SАVING ACTION OF TRIMETAZIDINE IN SUBJECTS WITH ACUTE MYOCARDIAL INFARCTION
Российский кардиологический журнал, 2014 The article concerns the assessment of functional condition of cell membranes in a variety of pathological conditions, influence of various physical and chemical factors and pharmacological drugs. Aim.
S. V. Vasilyev +2 more
doaj +1 more source
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]
, 2004 Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Duchen, M +3 more
core +1 more source