Results 191 to 200 of about 8,387 (243)

Trimetazidine as indirect antioxidant

Bulletin of Experimental Biology and Medicine, 2000
One-month therapy with trimetazidine sharply decreased the content of free radical oxidation products, lipid peroxides and malonic dialdehyde, in atherogenic low-density lipoproteins in patients with coronary heart disease. Activity of glutathione peroxidase utilizing lipid peroxides in the plasma markedly increased during trimetazidine therapy.
A K, Tikhaze, V Z, Lankin, E A, Zharova, S V, Kolycheva   +3 more
openaire   +2 more sources

Food Effect on Bioavailability of Modified-Release Trimetazidine Tablets

Journal of Clinical Pharmacology, 2012
This study aimed to investigate a food effect on the bioavailability of modified-release (MR) trimetazidine tablets in 36 healthy volunteers. Trimetazidine, an anti-ischemic drug, protects the myocardial cell from the harmful effects of ischemia.
Unal, Duri Şehvar, Ozbay, Latif, Erol, Dilek   +2 more
exaly   +2 more sources

Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways

Toxicology Mechanisms and Methods, 2023
Tramadol (TRA) causes neurotoxicity whereas trimetazidine (TMZ) is neuroprotective. The potential involvement of the PI3K/Akt/mTOR signaling pathway in the neuroprotection of TMZ against TRA-induced neurotoxicity was evaluated.
Houman Kamranian, Hadi Asoudeh, Roya Kamrani Sharif, F. Taheri, A. Hayes, M. Gholami, A. Alavi, M. Motaghinejad   +7 more
semanticscholar   +1 more source

Trimetazidine alleviates paclitaxel-induced peripheral neuropathy through modulation of TLR4/p38/NFκB and klotho protein expression.

Chemico-Biological Interactions, 2023
Chemotherapy-induced peripheral neuropathy is a common adverse effect associated with a number of chemotherapeutic agents including paclitaxel (PTX) which is commonly used in a wide range of solid tumors. Development of PTX-induced peripheral neuropathy (
A. Hammad, M. Sayed-Ahmed, S. A. Abdel Hafez, Ahmed R. N. Ibrahim, M. Khalifa, M. El-Daly   +5 more
semanticscholar   +1 more source

Evaluating the protective role of trimetazidine versus nano-trimetazidine in amelioration of bilateral renal ischemia/reperfusion induced neuro-degeneration: Implications of ERK1/2, JNK and Galectin-3 /NF-κB/TNF-α/HMGB-1 signaling.

Tissue & Cell, 2023
BACKGROUND Renal ischemia/reperfusion (I/R) is a primary culprit of acute kidney injury. Neurodegeneration can result from I/R, but the mechanisms are still challenging.
Fatma E. Hassan, B. Aboulhoda, Isra H Ali, Heba M. Elwi, L. Matter, Hend Abd-allah, M. M. Khalifa, Asmaa Selmy, Mansour A. Alghamdi, S. Morsy, Basant A. Al Dreny   +10 more
semanticscholar   +1 more source

Bentonite-in hypromellose-poloxamer sol-gel for corneal application of trimetazidine: Study of rheology and ocular anti inflammatory potential.

International Journal of Biological Macromolecules, 2023
Bentonite is reported to be used for extending ocular drug delivery safely in a controlled manner. Bentonite combined hydroxypropyl methylcellulose (HPMC)-poloxamer based sol-to-gel formulation has been developed for the prophylactic ocular anti ...
Rakesh Swain, Souvik Nandi, S. S. Swain, Krushna Prasad Pattanaik, S. Mohapatra, Dhananjay Panigrahi, S. Mallick   +6 more
semanticscholar   +1 more source

Impact of Trimetazidine on the Incident Heart Failure After Coronary Artery Revascularization

Journal of Cardiovascular Pharmacology, 2023
Supplemental Digital Content is Available in the Text. Abstract: Abnormal myocardial metabolism is a common pathophysiological process underlying ischemic heart disease and heart failure (HF). Trimetazidine is an antianginal agent with a unique mechanism
Sangwoo Park, Jun-Ping Chang, S. Hong, Eun-Sun Jin, M. Kong, H. Choi, S. Kwon, G. Park, Rae Woong Park   +8 more
semanticscholar   +1 more source

Trimetazidine and parkinsonism: A prospective study

Parkinsonism & Related Disorders, 2019
Although trimetazidine may induce parkinsonian symptoms in some patients, no systematic characterization has been reported on parkinsonism occurring during trimetazidine treatment since the first case reports.To systematically investigate parkinsonism occurring during trimetazidine use.Thirty-three consecutive patients on trimetazidine treatment with ...
Dávid Pintér, Márton Kovács, Márk Harmat, Annamária Juhász, József Janszky, Norbert Kovács   +5 more
openaire   +3 more sources

Antinociceptive effect of ranolazine and trimetazidine

Expert Review of Cardiovascular Therapy, 2021
Background:Ranolazine and trimetazidine are piperazine derivatives used in antianginal therapy. There are data on the use of these drugs in the treatment of neuropathic pain. In this study, it was aimed to evaluate the antinociceptive effects of ranolazine and trimetazidine.Methods: Sixty patients who were started on trimetazidine or ranolazine ...
openaire   +2 more sources

No fault or negligence after an adverse analytical finding due to a contaminated supplement: mission impossible. Two examples involving trimetazidine

Clinical Chemistry and Laboratory Medicine
Since several years, sports authorities, including national anti-doping organisations and the World Anti-Doping Agency (WADA) have published that the consumption of food supplements can be at risk for athletes due to potential contamination by prohibited
P. Kintz
semanticscholar   +1 more source