Results 201 to 210 of about 8,387 (243)

Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by modulating the Sirt3/Nrf2-GSH system and reducing Oxidative/Nitrative stress.

Biochemical Pharmacology
Ferroptosis is a newly defined mode of cellular demise. The increasing investigation supports that ferroptosis is a crucial factor in the complex mechanisms of myocardial ischemia-reperfusion (I/R) injury. Hence, targeting ferroptosis is a novel strategy
Ming-Yue Tan, Yunfei Yin, Weixiang Chen, Jun Zhang, Yifeng Jin, Yue Zhang, Lei Zhang, Tingbo Jiang, Bin Jiang, Hong-Xia Li   +9 more
semanticscholar   +1 more source

Solubility data determination and model correlation of trimetazidine hydrochloride in three mixed solvents

Physics and chemistry of liquids (Print)
Trimetazidine hydrochloride is a widely used drug in the treatment of cardiovascular diseases. In this experiment, the gravimetric method was employed to determine the solubility of trimetazidine hydrochloride in three mixed solvents (methanol + ethanol,
Yanmin Shen, Xiao-Chen Ye, Xueyi Wang, Jingwen Zhang, Zenan Gong, Ziyin Wang, Wen-Ju Liu, Xiao-Lu Wu   +7 more
semanticscholar   +1 more source

Trimetazidine in the Treatment of Chronic HeartFailure

Kardiologiia, 2016
The review presents data on alterations of mitochondrial oxidative metabolism occuring due to heart failure, mechanisms of cytoprotective agent trimetazidine associated with a partial inhibition of the fatty acid oxidation and increased metabolism of pyruvate, reduction of cardiomyocyte apoptosis and oxidative stress are described.
I V, Zhirov, Yu F, Osmolovskaya, S N, Tereshchenko   +2 more
openaire   +2 more sources

Evidence for the existence of [3H]-trimetazidine binding sites involved in the regulation of the mitochondrial permeability transition pore

British Journal of Pharmacology, 1998
1. Trimetazidine is an anti-ischaemic drug effective in different experimental models but its mechanism of action is not fully understood. Data indicate that mitochondria could be the main target of this drug.
MORIN didier, Bernard Testa, Pierre-Alain Carrupt   +2 more
exaly   +1 more source

Trimetazidine not beneficial after PCI

Nature Reviews Cardiology, 2020
Findings from the ATPCI trial show that trimetazidine is safe but not protective against angina and cardiac events in the long term after percutaneous coronary intervention.
openaire   +2 more sources

Targeting angiogenic and proliferative mediators by montelukast & trimetazidine Ameliorates thioacetamide-induced liver fibrosis in rats.

Toxicology and Applied Pharmacology
Liver fibrosis is a significant health complication with the potential to result in serious mortality and morbidity. However, there is no standard treatment due to its complex pathogenesis.
Rehab S. Abdelrahman, Ahmed A Elnfarawy, Asmaa E. Nashy, R. Abdelsalam, M. S. Zaghloul   +4 more
semanticscholar   +1 more source

Trimetazidine for stable angina pectoris

Expert Opinion on Pharmacotherapy, 2001
Stable angina pectoris, a symptom of coronary heart disease (CHD), manifests as stress-induced ischaemic episodes resulting in severe chest pain. Therapeutic aims are to improve quality of life by decreasing anginal attacks and to prevent myocardial infarction (MI) and death.
openaire   +2 more sources

Trimetazidine Use in Cardiovascular Disease

Cardiology in Review
Trimetazidine is an antianginal medication approved in numerous countries for use in the symptomatic treatment of stable coronary artery disease and angina pectoris. Its main mechanism of action revolves around the inhibition of β-oxidation of free fatty acids in the myocardium, in addition to its antioxidant properties and inhibition of cardiac ...
Mohammed, Kallash, William H, Frishman
openaire   +2 more sources

Anti-Excitotoxic Activity of Trimetazidine in the Retina

Journal of Ocular Pharmacology and Therapeutics, 2004
The purpose of this study was to investigate the mechanism of the neuroprotective activity of trimetazidine in animal retina stressed by ischemia or kainate. Flash electroretinograms were recorded in guinea pigs after ischemia, induced by an acute increase in the intraocular pressure (IOP), or after an intravitreal injection of kainate.
Olivier, Payet, Christine, D'Aldin, Laurence, Maurin, Claude, Bonne, Agnès, Muller   +4 more
openaire   +2 more sources

Role of Trimetazidine in Management of Ischemic Cardiomyopathy

The American Journal of Cardiology, 2006
Despite treatment with conventional agents, a high proportion of patients with ischemic cardiomyopathy continue to have symptoms. Moreover, a substantial proportion shows progressive contractile dysfunction leading to left ventricular (LV) enlargement and heart failure. Therefore, a need exists for new treatments for ischemic cardiomyopathy that tackle
Vicente, Bertomeu-Gonzalez, Alberto, Bouzas-Mosquera, Juan Carlos, Kaski   +2 more
openaire   +2 more sources