Results 81 to 90 of about 12,013 (243)

Cardiac Calcitropes, Myotropes, and Mitotropes: JACC Review Topic of the Week. [PDF]

, 2019
The term "inotrope" is familiar and intimately connected with pharmaceuticals clinically used for treatment of low cardiac output with cardiogenic shock.
Adams, KF, Allen, LA, Francis, GS, Gottlieb, SS, Lancellotti, P, Psotka, MA, Rosano, GMC, Teerlink, JR   +7 more
core   +2 more sources

The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, Volume 27, Issue 9, Page 1700-1719, September 2025.
Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso, Davide Stolfo, Markus S. Anker, Antoni Bayes‐Genis, Ovidiu Chioncel, Stephane Heymans, Pardeep S. Jhund, Basil S. Lewis, Gary D. Lopaschuk, Lars H. Lund, Arantxa Gonzalez, Matteo Pagnesi, Gabriele Giacomo Schiattarella, Carlo Gabriele Tocchetti, Peter van der Meer, Sophie Van Linthout, Sven Wassmann, B. Daan Westenbrink, Marco Metra, Giuseppe M.C. Rosano, Gianluigi Savarese   +20 more
wiley   +1 more source

Epithelial–Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications

MedComm, Volume 6, Issue 9, September 2025.
This graphical abstract summarizes the effects of ionizing radiation (IR) on epithelial–mesenchymal transition (EMT), emphasizing critical processes such as DNA damage repair, tumor microenvironment interactions, and resistance mechanisms. It highlights EMT‐induced radioresistance regulators, such as TGF‐β, Wnt, Notch, ERK, and various miRNAs, as well ...
Dhasarathdev Srinivasan, Ranjith Balakrishnan, Ankush Chauhan, Jeevan Kumar, Dinesh Murugan Girija, Reena Shrestha, Rupendra Shrestha, Rajasekaran Subbarayan   +7 more
wiley   +1 more source

TRIMETAZIDINE ADDITION TO ANTIANGINAL THERAPY: EFFECTS ON EFFICACY AND QUALITY OF LIFE IN PATIENTS WITH STABLE ANGINA TREATED OUTPATIENTLY

Терапевтический архив, 2012
Aim. To compare effects of original trimetazidine versus its generics addition to antianginal treatment efficacy and quality of life in patients with stable angina (SA). Material and methods.
M A Shalenkova
doaj  

Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study

Cardiovascular Diabetology, 2003
Background Patients with diabetic cardiomyopathy have an impaired myocardial glucose handling and distal distribution of coronary atherosclerosis. Trimetazidine, an anti-ischemic metabolic agent, improves myocardial glucose utilization though inhibition ...
Mercuro Giuseppe, Sposato Barbara, Vitale Cristiana, Rosano Giuseppe MC, Fini Massimo   +4 more
doaj   +1 more source

Trimetazidine has Promising Preventive Effects on Experimental Chronic Pancreatitis Rat Model.

The Turkish Journal of Gastroenterology, 2022
BACKGROUND It was aimed to evaluate the preventive efficacy of trimetazidine in an experimental chronic pancreatitis rat model. METHODS Chronic pancreatitis model was accomplished with caerulein and alcohol administration.
M. Kaplan, Arif Karakaya, A. Tanoğlu, Muhammet Yıldırım, Yeşim Önal Taştan, Zafer Çırak, Zafer Küçükodacı   +6 more
semanticscholar   +1 more source

Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]

, 2014
Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora, Barreiro, Eshter, Chacon Cabrera, Alba, Diament, Miriam, Fermoselle, Clara, Mateu Jimenez, Mercè, Sandri, Marco, Urtreger, Alejandro Jorge   +7 more
core   +1 more source

Defining Treatment‐Resistant Bipolar Depression: Recommendations From the ISBD Task Force

Bipolar Disorders, Volume 27, Issue 6, Page 411-423, September 2025.
ABSTRACT Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking.
Eduard Vieta, Roger S. McIntyre, Trisha Suppes, Tamsyn E. Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H. Young, Lakshmi N. Yatham, Kyooseob Ha, Michael Berk, Holly A. Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J. Cubała, Diego Hidalgo‐Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez‐Jaramillo, Ana Gonzalez‐Pinto, Paolo Brambilla, Robert Post, Jair C. Soares, Michael Bauer, Ana C. Andreazza, Xavier Justes Fradera, Montserrat Cosials‐Lopez, Giovanna Fico   +29 more
wiley   +1 more source

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice

British Journal of Pharmacology, 2021
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles and is currently incurable. Although considered to be a pure motor
Silvia Scaricamazza, I. Salvatori, S. Amadio, V. Nesci, Alessio Torcinaro, G. Giacovazzo, A. Primiano, M. Gloriani, Niccolò Candelise, L. Pieroni, J. Loeffler, F. René, Cyril Quessada, T. Tefera, Hao Wang, F. Steyn, S. Ngo, G. Dobrowolny, E. Lepore, A. Urbani, A. Musarò, C. Volonté, E. Ferraro, R. Coccurello, Cristiana Valle, A. Ferri   +25 more
semanticscholar   +1 more source

Physiological monitoring in the complex multi-morbid heart failure patient - Introduction. [PDF]

, 2019
Repeated physiological monitoring of comorbidities in heart failure (HF) is pivotal. This document introduces the main challenges related to physiological monitoring in the complex multimorbid HF patient, arising during an ESC consensus meeting on this ...
Rosano, GMC, Seferović, PM
core   +1 more source