Results 1 to 10 of about 21,737 (203)

Supersaturating drug delivery system of fixed drug combination: sulfamethoxazole and trimethoprim

Expert Review of Anti-Infective Therapy, 2019
Background: The drug supersaturation in the intestinal lumen for few hours could result in high bioavailability. The goal of this study was the development of a supersaturating drug delivery system containing sulfamethoxazole and trimethoprim at fixed dose combination (sulfamethoxazole:trimethoprim 5:1 w/w).
Cassiana Mendes, Giuliana Valentini, Andres Felipe Chamorro   +2 more
exaly   +4 more sources

Multisensory Systems Based on Perfluorosulfonic Acid Membranes Modified with Functionalized CNTs for Determination of Sulfamethoxazole and Trimethoprim in Pharmaceuticals

Membranes, 2022
Sulfamethoxazole and trimethoprim are synthetic bacteriostatic drugs. A potentiometric multisensory system for the analysis of sulfamethoxazole and trimethoprim combination drugs was developed.
Anna Parshina, Anastasia Yelnikova, Ekaterina Safronova, Tatyana Kolganova, Victoria Kuleshova, Olga Bobreshova, Andrey Yaroslavtsev   +6 more
doaj   +2 more sources

Manifestations and Management of Trimethoprim/Sulfamethoxazole–Resistant Nocardia otitidiscaviarum Infection

Emerging Infectious Diseases, 2023
Nocardia can cause systemic infections with varying manifestations. Resistance patterns vary by species. We describe N. otitidiscavarium infection with pulmonary and cutaneous manifestations in a man in the United States. He received multidrug treatment
Katherine Fu, Kyle White, Aliaksandr Ramaniuk, Vidya Kollu, Daniel Urbine   +4 more
doaj   +2 more sources

The Inhibitory Effect of Adenylic Acid on the Bitterness of the Antibacterial Combination Drug Trimethoprim/Sulfamethoxazole

Chemical and Pharmaceutical Bulletin, 2023
The purpose of the present study was to evaluate bitterness suppression effect of adenylic acid (AMP) as a nucleotide-derived nutrient enhancer on a bitter commercial drug. In the present study, we evaluated peripheral bitterness inhibition effect of AMP on the trimethoprim (TMP) and sulfamethoxazole (SMZ) combination formulation based on taste sensor.
Miyako Yoshida, Honami Kojima, Ikuo Kawasaki   +2 more
exaly   +3 more sources

Comparative evaluation of trimethoprim-sulfonamide ratios and synergistic interactions against porcine respiratory pathogens [PDF]

Frontiers in Veterinary Science
IntroductionPotentiated sulfonamides are widely used in the treatment of porcine respiratory disease complex, but their synergistic activity depends on pathogen-related and pharmacodynamic factors, including the trimethoprim-to-sulfonamide ratio.
Patrik Mag, Patrik Mag, Ulrich Klein, Wouter Depondt, Imre Sándor Piross, Imre Sándor Piross, Réka Tóth, Zoltán Somogyi, Dóra Kovács, Dóra Kovács, Ádám Kerek, Ádám Kerek, Ákos Jerzsele, Ákos Jerzsele   +13 more
doaj   +2 more sources

Dosage Optimisation of Trimethoprim and Sulfamethoxazole for the Treatment of an Avian Pathogenic Strain of Escherichia coli in Broiler Chickens

Antibiotics, 2023
Based on pharmacokinetic studies carried out according to the methodologies defined by the European Medicines Agency (EMA) using mass spectrometry analysis, a new formulation of a veterinary drug for the treatment of broiler chickens is proposed ...
Kamil Stastny, Nikola Hodkovicova, Martin Jerabek, Michal Petren, Michaela Viskova, Aneta Papouskova, Iva Bartejsova, Kristina Putecova-Tosnerova, Michaela Charvatova, Monika Zouharova, Katarina Matiaskova, Katerina Nedbalcova   +11 more
doaj   +2 more sources

Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion [PDF]

Metabolites
Background/Objectives: The increased use of antibiotics is raising concerns about environmental contamination and antibiotic resistance, exemplified by the case of cotrimoxazole, a widely prescribed combination of sulfamethoxazole and trimethoprim. After
Marieke A. J. Hof, Hessel de Haan, Stepan Stepanovic, Stephan J. L. Bakker, Eelko Hak, Gérard Hopfgartner, Frank Klont, TransplantLines Investigators   +7 more
doaj   +3 more sources

Burkholderia pseudomallei in Sarawak, Malaysian Borneo, Remains Highly Susceptible to Trimethoprim-Sulfamethoxazole Despite Resistance to Its Individual Components [PDF]

Pathogens
Burkholderia pseudomallei, the causative agent of melioidosis, is endemic in Sarawak, Malaysian Borneo, where it is represented by a unique gentamicin-susceptible population. Despite trimethoprim-sulfamethoxazole (co-trimoxazole) being the cornerstone of
Liana Lantong Sumbu, Tonnii Loong-Loong Sia, Mong-How Ooi, Anand Mohan, Jin-Shyan Wong, Yuwana Podin   +5 more
doaj   +2 more sources

Simultaneous determination of concentration of sulfamethoxazole and trimethoprim in human plasma by dual-quaternary HPLC and its clinical application

Precision Medication
Sulfamethoxazole compound, a combination of sulfamethoxazole and trimethoprim, is commonly prescribed to organ transplant recipients for infections caused by Nocardia, Burkholderia cepacia, and Pneumocystis jirovecii.
Li Nong, Yunxia Tang, Xiaoning Qin, Zhou Zhou, Zongqiang Lai, WenXing Wei, Wenwen Tan   +6 more
doaj   +2 more sources

Evaluation of Adverse Events Associated with the Sulfamethoxazole/Trimethoprim Combination Drug

Journal of Clinical Medicine
Background/Objectives: The combination drug sulfamethoxazole/trimethoprim (ST) is a broad-spectrum antibiotic used against various infections; however, it is associated with several serious adverse events. The ST package inserts contain warnings about these adverse events.
Takaya Sagawa, Tomoaki Ishida, Kohei Jobu, Shumpei Morisawa, Keita Akagaki, Takahiro Kato, Takumi Maruyama, Yusuke Yagi, Tomomi Kihara, Sanae Suzuki, Mio Endo, Nobuaki Matsunaga, Yukihiro Hamada   +12 more
openaire   +3 more sources