Chemical and Pharmaceutical Bulletin, 2023 The purpose of the present study was to evaluate bitterness suppression effect of adenylic acid (AMP) as a nucleotide-derived nutrient enhancer on a bitter commercial drug. In the present study, we evaluated peripheral bitterness inhibition effect of AMP on the trimethoprim (TMP) and sulfamethoxazole (SMZ) combination formulation based on taste sensor.
Takahiro Uchida +2 more
exaly +3 more sources
Comparative evaluation of trimethoprim-sulfonamide ratios and synergistic interactions against porcine respiratory pathogens [PDF]
Frontiers in Veterinary ScienceIntroductionPotentiated sulfonamides are widely used in the treatment of porcine respiratory disease complex, but their synergistic activity depends on pathogen-related and pharmacodynamic factors, including the trimethoprim-to-sulfonamide ratio.
Patrik Mag +13 more
doaj +2 more sources
The Combination of Sulfamethoxazole, Trimethoprim, and Isoniazid or Rifampin Is Bactericidal and Prevents the Emergence of Drug Resistance in Mycobacterium tuberculosis [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACT The challenges of developing new drugs to treat tuberculosis (TB) are indicated by the relatively small number of candidates entering clinical trials in the past decade. To overcome these issues, we reexamined two FDA-approved antibacterial drugs, sulfamethoxazole (SMX) and trimethoprim (TMP), for use in TB treatment ...
Catherine Vilchèze, William Jacobs
exaly +3 more sources
Burkholderia pseudomallei in Sarawak, Malaysian Borneo, Remains Highly Susceptible to Trimethoprim-Sulfamethoxazole Despite Resistance to Its Individual Components [PDF]
PathogensBurkholderia pseudomallei, the causative agent of melioidosis, is endemic in Sarawak, Malaysian Borneo, where it is represented by a unique gentamicin-susceptible population. Despite trimethoprim-sulfamethoxazole (co-trimoxazole) being the cornerstone of
Liana Lantong Sumbu +5 more
doaj +2 more sources
Evaluation of Adverse Events Associated with the Sulfamethoxazole/Trimethoprim Combination Drug
Journal of Clinical MedicineBackground/Objectives: The combination drug sulfamethoxazole/trimethoprim (ST) is a broad-spectrum antibiotic used against various infections; however, it is associated with several serious adverse events. The ST package inserts contain warnings about these adverse events.
Yukihiro Hamada +2 more
exaly +3 more sources
Supersaturating drug delivery system of fixed drug combination: sulfamethoxazole and trimethoprim
Expert Review of Anti-Infective Therapy, 2019 Background: The drug supersaturation in the intestinal lumen for few hours could result in high bioavailability. The goal of this study was the development of a supersaturating drug delivery system containing sulfamethoxazole and trimethoprim at fixed dose combination (sulfamethoxazole:trimethoprim 5:1 w/w).
Andres Felipe Chamorro Rengifo +2 more
exaly +3 more sources
Acute Liver Injury Following Outpatient Trimethoprim‐Sulfamethoxazole Use for Small Intestinal Bacterial Overgrowth: A Case Report [PDF]
Clinical Case ReportsDrug‐induced liver injury (DILI) is a leading cause of acute liver failure in the United States and remains difficult to predict and diagnose. Trimethoprim‐sulfamethoxazole (TMP‐SMX) is widely prescribed and generally well tolerated, yet rare cases of ...
Kaylie Duit +3 more
doaj +2 more sources
Case Report: Pulmonary nocardiosis: three case reports and literature review [PDF]
Frontiers in MedicinePulmonary nocardiosis is a relatively uncommon opportunistic infection characterized by nonspecific clinical features, often leading to delays in diagnosis and treatment.
Qi Zhao +4 more
doaj +2 more sources
Toxicity-guided dose modification for disseminated Nocardia farcinica brain abscess in a patient with pneumoconiosis: a brief research report [PDF]
Frontiers in PharmacologyBackgroundOptimal antimicrobial strategies for disseminated nocardiosis with central nervous system (CNS) involvement remain poorly defined, particularly regarding trimethoprim-sulfamethoxazole (TMP-SMX) dosing in immunocompromised patients with severe ...
Hui Juan Liu +3 more
doaj +2 more sources
Membranes, 2022 Sulfamethoxazole and trimethoprim are synthetic bacteriostatic drugs. A potentiometric multisensory system for the analysis of sulfamethoxazole and trimethoprim combination drugs was developed.
Anna Parshina +6 more
doaj +1 more source