Results 131 to 140 of about 55,281 (292)

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, EarlyView.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing [PDF]

, 2017
Yiran Guo, Liang‐Dar Hwang, Jiankang Li, Jason Eades, Chung Wen Yu, Corrine Mansfield, Alexis Burdick-Will, Xiao Chang, Yulan Chen, Fujiko Duke, Jian‐Guo Zhang, Steven Fakharzadeh, Paul V. Fennessey, Brendan J. Keating, Hui Jiang, Håkon Håkonarson, Danielle R. Reed, George Preti   +17 more
openalex   +1 more source

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

Gut Microbiota-Derived Trimethylamine Promotes Inflammation with a Potential Impact on Epigenetic and Mitochondrial Homeostasis in Caco-2 Cells

Antioxidants
Trimethylamine (TMA), a byproduct of gut microbiota metabolism from dietary precursors, is not only the precursor of trimethylamine-N-oxide (TMAO) but may also affect gut health.
Laura Bordoni, Irene Petracci, Giulia Feliziani, Gaia de Simone, Chiara Rucci, Rosita Gabbianelli   +5 more
doaj   +1 more source

Comparative genomics and proteomics of Eubacterium maltosivorans : functional identification of trimethylamine methyltransferases and bacterial microcompartments in a human intestinal bacterium with a versatile lifestyle [PDF]

, 2022
Yuan Feng, Thi Phuong Nam Bui, Alfons J. M. Stams, Sjef Boeren, Irene Sánchez‐Andrea, Willem M. de Vos   +5 more
openalex   +1 more source

Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS‐Induced Colitis

Immunology, EarlyView.
C57BL/6 mice from Charles River Laboratories (CR) have enhanced mucosal immune action relative to C57BL/6 mice from Jackson Laboratories (JAX). CR mice are more susceptible to severe DSS‐induced colitis than JAX mice. Co‐housing transfers colitis susceptibility from CR mice to JAX mice.
Jessica M. Till, Orion D. Brock, Elyza A. Do, Morgan J. Engelhart, Robert W. P. Glowacki, Shaomin Hu, Ansel Hsiao, Ina Nemet, Philip P. Ahern   +8 more
wiley   +1 more source

Reduction of trimethylamine N-oxide to trimethylamine by the human gut microbiota: supporting evidence for ‘metabolic retroversion’ [PDF]

, 2015
Dietary sources of methylamines such as choline, trimethylamine (TMA), trimethylamine N-oxide (TMAO), phosphatidylcholine (PC) and carnitine are present in a number of foodstuffs, including meat, fish, nuts and eggs.
Chilloux, J, Dumas, ME, Hoyles, L, Jiménez-Pranteda, ML, McCartney, AL   +4 more
core  

Fasting and postprandial trimethylamine N ‐oxide in sedentary and endurance‐trained males following a short‐term high‐fat diet [PDF]

, 2021
Cortney Steele, Mary Elizabeth Baugh, Laura E. Griffin, Andrew P. Neilson, Brenda M. Davy, Matthew W. Hulver, Kevin P. Davy   +6 more
openalex   +1 more source

Efficacy of probiotics (Bifidobacterium bifidum G9‐1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open‐label, single‐arm study (BIRDIE study)

Journal of Diabetes Investigation, EarlyView.
Bifidobacterium bifidum G9‐1 improved stool form, defecation frequency, and Quality of Life in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation. ABSTRACT Introduction Although constipation is a major complication of type 2 diabetes mellitus and chronic kidney disease, evidence for its treatment in these ...
Fuki Ikeda, Junko Sato, Hidenori Yoshii, Masahiro Sugawara, Hiroaki Satoh, Yukiko Sugawara, Hirotsugu Uzawa, Daisuke Sugimoto, Reina Muto, Yuya Nishida, Hirotaka Watada   +10 more
wiley   +1 more source

Specific Nature of Hydrolysis of Insulin and Tobacco Mosaic Virus Protein by Thermolysin [PDF]

Oxidized bovine insulin and tobacco mosaic virus protein used to determine hydrolysis specificity of ...
Jukes, T. H., Matsubara, H., Sasaki, R., Singer, A.   +3 more
core   +1 more source