Results 1 to 10 of about 553,444 (284)

Gut microbiota dependant trimethylamine N-oxide and hypertension

Frontiers in Physiology, 2023
The human gut microbiota environment is constantly changing and some specific changes influence the host’s metabolic, immune, and neuroendocrine functions.
Katongo H. Mutengo, Katongo H. Mutengo, Sepiso K. Masenga, Sepiso K. Masenga, Aggrey Mweemba, Wilbroad Mutale, Annet Kirabo   +6 more
doaj   +4 more sources

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Redox Biology, 2021
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis.
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng   +19 more
doaj   +4 more sources

Trimethylamine-N-oxide and cerebral stroke risk: A review

Neurobiology of Disease
Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced by the action of gut microbiota and the hepatic enzyme Flavin Mono‑oxygenase 3 (FMO3).
Phurbu Dolkar, Tenzin Deyang, Nikhilesh Anand, Annan Gopinath Rathipriya, Tousif Ahmed Hediyal, Vichitra Chandrasekaran, Naveen Kumar Krishnamoorthy, Vasavi Rakesh Gorantla, Muhammed Bishir, Luay Rashan, Sulie L. Chang, Meena Kishore Sakharkar, Jian Yang, Saravana Babu Chidambaram   +13 more
doaj   +4 more sources

The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

Cell Metabolism, 2022
Immunotherapy has achieved limited success in patients with triple-negative breast cancer (TNBC), an aggressive disease with a poor prognosis. Commensal microbiota have been proven to colonize the mammary gland, but whether and how they modulate the ...
Hai Wang, Yi Xiao, Xi Jin
exaly   +2 more sources

Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

Microbiome, 2021
Background Communication between the gut microbiota and the brain is primarily mediated via soluble microbe-derived metabolites, but the details of this pathway remain poorly defined. Methylamines produced by microbial metabolism of dietary choline and l-
Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Müller, Robert C. Glen, David Vauzour, Simon McArthur   +13 more
doaj   +2 more sources

Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms

Circulation, 2023
Background: Large-scale human and mechanistic mouse studies indicate a strong relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) and several cardiometabolic diseases.
Xinmin S Li, Zeneng Wang, Robert N Helsley   +2 more
exaly   +2 more sources

The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

Frontiers in Endocrinology, 2023
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide. Researchers have found that the occurrence and development of CVDs are closely related to intestinal microecology.
Jing Zhen, Jing Zhen, Zhou Zhou, Meng He, Hai-Xiang Han, En-Hui Lv, Peng-Bo Wen, Xin Liu, Yan-Ting Wang, Xun-Chao Cai, Jia-Qi Tian, Meng-Ying Zhang, Lei Xiao, Xing-Xing Kang   +13 more
doaj   +2 more sources

Association between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults [PDF]

Lipids in Health and Disease
Background Egg-derived phosphatidylcholine may support the maintenance of cognitive function. However, its metabolite trimethylamine N-oxide is considered a potential cardiovascular risk factor.
Wei Wang, Yumi Takeda, Mamoru Kimura, Ryosuke Matsuoka, Tsutomu Hashimoto, Noriyuki Yanaka, Michihiro Sugano   +6 more
doaj   +2 more sources

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

Cell Metabolism, 2019
The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin resistance and associated with several sequelae of metabolic syndrome in humans, including cardiovascular, renal, and neurodegenerative disease.
Sifan Chen, Ayana L Henderson, Michael C Petriello   +2 more
exaly   +2 more sources

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

Nature Communications
β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes could directly decrease glucose-stimulated insulin secretion (GSIS) in MIN6 ...
Lijuan Kong, Qijin Zhao, Xiaojing Jiang, Jinping Hu, Qian Jiang, Li Sheng, Xiaohong Peng, Shusen Wang, Yibing Chen, Yanjun Wan, Shaocong Hou, Xingfeng Liu, Chunxiao Ma, Yan Li, Li Quan, Liangyi Chen, Bing Cui, Pingping Li   +17 more
doaj   +2 more sources