Results 1 to 10 of about 19,127 (154)

Trimethylamine N-Oxide, a Bariatric Surgery-Associated Host-Microbial Cometabolite, Reduces Colonic Tumorigenesis in a Sex-Dependent Manner. [PDF]

Cell Mol Gastroenterol Hepatol
Background & Aims: Trimethylamine N -oxide is a host–microbial cometabolite that significantly increases following Roux-en-Y gastric bypass. Although trimethylamine N -oxide is associated with cardiovascular diseases, its role in colorectal cancer ...
Bi Y, Glymenaki M, Valdivia-Garcia MA, Wang M, Eng KY, Lin E, Gletsu-Miller N, Marchesi JR, Smits R, El-Bahrawy M, Guerra N, Li JV.   +11 more
europepmc   +2 more sources

Trimethylamine N-Oxide as a Potential Biomarker for Cardiovascular Disease: Its Association with Dietary Sources of Trimethylamine N-Oxide and Microbiota

Eurasian Journal of Medicine, 2023
Trimethylamine N-oxide (TMAO), the oxidized form of trimethylamine (TMA), was previously thought to be a waste product but is now considered an important risk factor for cardiovascular disease (CVD) and its comorbidities. Foods or supplements containing
Yasemin Karaagac
doaj   +3 more sources

Gut microbiota dependant trimethylamine N-oxide and hypertension

Frontiers in Physiology, 2023
The human gut microbiota environment is constantly changing and some specific changes influence the host’s metabolic, immune, and neuroendocrine functions.
Katongo H. Mutengo, Katongo H. Mutengo, Sepiso K. Masenga, Sepiso K. Masenga, Aggrey Mweemba, Wilbroad Mutale, Annet Kirabo   +6 more
doaj   +3 more sources

Trimethylamine N-oxide—a marker for atherosclerotic vascular disease [PDF]

Reviews in Cardiovascular Medicine, 2021
As a potential causative factor in various cardiovascular diseases, the gut microbe-generated metabolite trimethylamine N-oxide (TMAO) has courted considerable research interest as a potential biomarker.
Guinan Xie, An Yan, Peng Lin, Yi Wang, Liping Guo   +4 more
doaj   +3 more sources

Longitudinal metabolomics reveals dynamic associations of trimethylamine N-oxide and precursors with the progression of gestational diabetes. [PDF]

BMC Pregnancy Childbirth
Background Trimethylamine N-oxide (TMAO) and its precursor metabolites are strongly linked to glucose and lipid metabolic disorders, yet their dynamic roles and overall effects in gestational diabetes mellitus (GDM) have not been clarified.
Wu Y, Ni Z, Liu S, Fang S, Li Y, Lu Q, Ye D, Zang S, Jiang G.   +8 more
europepmc   +2 more sources

Association between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults. [PDF]

Lipids Health Dis
Background Egg-derived phosphatidylcholine may support the maintenance of cognitive function. However, its metabolite trimethylamine N-oxide is considered a potential cardiovascular risk factor.
Wang W, Takeda Y, Kimura M, Matsuoka R, Hashimoto T, Yanaka N, Sugano M.   +6 more
europepmc   +2 more sources

Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk ...
Liang Shen
exaly   +3 more sources

<i>Porphyromonas gingivalis</i> drives trimethylamine-N-oxide accumulation via modulation of gut microbial trimethylamine lyase in mice. [PDF]

Front Microbiol
IntroductionTrimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, is linked to cardiovascular, neurodegenerative, and metabolic diseases. Emerging evidence indicates a bidirectional interaction between the periodontal pathogen Porphyromonas
Xie W, Han D, Tan J, Zhao D, Dong J, Wu J, Yang X, Xie S.   +7 more
europepmc   +2 more sources

Atherosclerosis and trimethylamine-N-oxide — the gut microbiota potential

Российский кардиологический журнал, 2022
Gut dysbiosis contribute to the development of atherosclerosis. Firmicutes contain a trimethylamine-producing gene cluster. The aim was to analyze potential role of trimethylamine-N-oxide (TMAO), gut microbiota metabolite, in the pathogenesis of ...
I. N. Grigorieva
doaj   +1 more source

Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA) Determinations of Two Hadal Amphipods

Journal of Marine Science and Engineering, 2022
Hadal trenches are a unique habitat with high hydrostatic pressure, low temperature and scarce food supplies. Amphipods are the dominant scavenging metazoan species in this ecosystem.
Qi Liu, Shouwen Jiang, Wenhao Li, Binbin Pan, Qianghua Xu   +4 more
doaj   +1 more source