The microbial metabolite trimethylamine N-oxide and the kidney diseases [PDF]
Frontiers in Cellular and Infection MicrobiologyTrimethylamine N-oxide (TMAO), a metabolite, is a co-metabolite produced by both gut microbiota and livers, originating from foods rich in choline or carnitine.
Jin-Qi Su +15 more
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Eurasian Journal of Medicine, 2023 Trimethylamine N-oxide (TMAO), the oxidized form of trimethylamine (TMA), was previously thought to be a waste product but is now considered an important risk factor for cardiovascular disease (CVD) and its comorbidities. Foods or supplements containing
Yasemin Karaagac
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Trimethylamine N-oxide in atrial fibrillation progression
International Journal of Cardiology: Heart & Vasculature, 2020 The human gut microbiome and its metabolite Trimethylamine N-oxide (TMAO) are sensitive to the human diet and are involved in the complex pathomechanisms that underpin diabetes, obesity, and cardiovascular diseases.
Petra Büttner +7 more
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Association between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults [PDF]
Lipids in Health and DiseaseBackground Egg-derived phosphatidylcholine may support the maintenance of cognitive function. However, its metabolite trimethylamine N-oxide is considered a potential cardiovascular risk factor.
Wei Wang +6 more
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Gut microbiota dependant trimethylamine N-oxide and hypertension
Frontiers in Physiology, 2023 The human gut microbiota environment is constantly changing and some specific changes influence the host’s metabolic, immune, and neuroendocrine functions.
Katongo H. Mutengo +6 more
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Longitudinal metabolomics reveals dynamic associations of trimethylamine N-oxide and precursors with the progression of gestational diabetes [PDF]
BMC Pregnancy and ChildbirthBackground Trimethylamine N-oxide (TMAO) and its precursor metabolites are strongly linked to glucose and lipid metabolic disorders, yet their dynamic roles and overall effects in gestational diabetes mellitus (GDM) have not been clarified.
Yuwen Wu +8 more
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Trimethylamine N-oxide—a marker for atherosclerotic vascular disease [PDF]
Reviews in Cardiovascular Medicine, 2021 As a potential causative factor in various cardiovascular diseases, the gut microbe-generated metabolite trimethylamine N-oxide (TMAO) has courted considerable research interest as a potential biomarker.
Guinan Xie +4 more
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Trimethylamine N-Oxide: The Good, the Bad and the Unknown [PDF]
Toxins, 2016 Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism. It accumulates in the tissue of marine animals in high concentrations and protects against the protein ...
Manuel T. Velasquez +3 more
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Role of Trimethylamine N-Oxide in Heart Failure
Reviews in Cardiovascular MedicineHeart failure (HF) is a clinical syndrome characterizing by typical physical signs and symptomatology resulting from reduced cardiac output and/or intracardiac pressure at rest or under stress due to structural and/or functional abnormalities of the ...
Lele Jing +6 more
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Porphyromonas gingivalis drives trimethylamine-N-oxide accumulation via modulation of gut microbial trimethylamine lyase in mice [PDF]
Frontiers in MicrobiologyIntroductionTrimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, is linked to cardiovascular, neurodegenerative, and metabolic diseases. Emerging evidence indicates a bidirectional interaction between the periodontal pathogen Porphyromonas
Weige Xie +7 more
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