Results 11 to 20 of about 17,902 (222)

Trimethylamine-N-oxide and cerebral stroke risk: A review

Neurobiology of Disease
Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced by the action of gut microbiota and the hepatic enzyme Flavin Mono‑oxygenase 3 (FMO3).
Phurbu Dolkar, Tenzin Deyang, Nikhilesh Anand, Annan Gopinath Rathipriya, Tousif Ahmed Hediyal, Vichitra Chandrasekaran, Naveen Kumar Krishnamoorthy, Vasavi Rakesh Gorantla, Muhammed Bishir, Luay Rashan, Sulie L. Chang, Meena Kishore Sakharkar, Jian Yang, Saravana Babu Chidambaram   +13 more
doaj   +3 more sources

Trimethylamine N‐Oxide and Mortality Risk in Patients With Peripheral Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundProduction of the proatherogenic metabolite, trimethylamine N‐oxide (TMAO), from dietary nutrients by intestinal microbiota enhances atherosclerosis development in animal models and is associated with atherosclerotic coronary artery disease in ...
Vichai Senthong, Zeneng Wang, Yiying Fan, Yuping Wu, Stanley L. Hazen, W. H. Wilson Tang   +5 more
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Trimethylamine N-oxide in cardiovascular disease

Advances in Clinical and Experimental Medicine, 2022
Although traditional cardiovascular risk factors are well established and understood, mortality and morbidity in patients with cardiovascular disease (CVD) remains high. Exploring new pathophysiological pathways enables a better understanding of CVD at both the molecular and clinical levels.
Radoslaw Konieczny, Wiktor Kuliczkowski
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Atherosclerosis and trimethylamine-N-oxide — the gut microbiota potential

Российский кардиологический журнал, 2022
Gut dysbiosis contribute to the development of atherosclerosis. Firmicutes contain a trimethylamine-producing gene cluster. The aim was to analyze potential role of trimethylamine-N-oxide (TMAO), gut microbiota metabolite, in the pathogenesis of ...
I. N. Grigorieva
doaj   +1 more source

Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA) Determinations of Two Hadal Amphipods

Journal of Marine Science and Engineering, 2022
Hadal trenches are a unique habitat with high hydrostatic pressure, low temperature and scarce food supplies. Amphipods are the dominant scavenging metazoan species in this ecosystem.
Qi Liu, Shouwen Jiang, Wenhao Li, Binbin Pan, Qianghua Xu   +4 more
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Fecal Microbiome Composition Does Not Predict Diet‐Induced TMAO Production in Healthy Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Trimethylamine‐N‐oxide (TMAO) is a small molecule derived from the metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease. Plasma TMAO increases following consumption of red meat.
Marc Ferrell, Peter Bazeley, Zeneng Wang, Bruce S. Levison, Xinmin S. Li, Xun Jia, Ronald M. Krauss, Rob Knight, Aldons J. Lusis, J. C. Garcia‐Garcia, Stanley L. Hazen, W. H. Wilson Tang   +11 more
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Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

Microbiome, 2021
Background Communication between the gut microbiota and the brain is primarily mediated via soluble microbe-derived metabolites, but the details of this pathway remain poorly defined. Methylamines produced by microbial metabolism of dietary choline and l-
Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Müller, Robert C. Glen, David Vauzour, Simon McArthur   +13 more
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Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke

Frontiers in Neurology, 2023
Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly ...
Yuan Liu, Juan Qu, Junjie Xu, Aiming Gu, Dezhi Deng, Xiaodan Jia, Baoxiang Wang   +6 more
doaj   +1 more source

Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide [PDF]

Journal of Stroke, 2019
Trimethylamine N-oxide (TMAO) is produced when trimethylamine, a waste product of gut microbes, is converted via hepatic flavin monooxygenases. As TMAO is a potential causative factor in various cardiovascular diseases (CVDs) considerable research ...
Hyo Suk Nam
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The biosynthesis of trimethylamine-N-oxide

Biochimica et Biophysica Acta, 1960
Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in
J, BAKER, S, CHAYKIN
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