Results 11 to 20 of about 11,163,062 (259)
Trimethylamine N-oxide in cardiovascular disease
Advances in Clinical and Experimental Medicine, 2022 Although traditional cardiovascular risk factors are well established and understood, mortality and morbidity in patients with cardiovascular disease (CVD) remains high. Exploring new pathophysiological pathways enables a better understanding of CVD at both the molecular and clinical levels.
Radoslaw Konieczny, Wiktor Kuliczkowski
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The biosynthesis of trimethylamine-N-oxide
Biochimica et Biophysica Acta, 1960 Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in
J, BAKER, S, CHAYKIN
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Trimethylamine N-oxide (TMAO) in human health
EXCLI journal, 2021 Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and diseases, this topic is very popular and is often taken up by researchers. TMAO is a low molecular weight compound that belongs to the class of amine oxides. It is formed by the process of oxidation of trimethylamine (TMA) by the hepatic flavin monooxygenases (FMO1 ...
Gatarek, Paulina +1 more
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Trimethylamine N-Oxide: The Good, the Bad and the Unknown [PDF]
Toxins, 2016 Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism. It accumulates in the tissue of marine animals in high concentrations and protects against the protein-destabilizing effects of urea.
Manuel T. Velasquez +3 more
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Trimethylamine N‐oxide: breathe new life [PDF]
British Journal of Pharmacology, 2017 Association between elevated levels of systemic trimethylamine N‐oxide (TMAO) and increased risk for adverse cardiovascular events have been proposed in recent years. Increasing experimental and clinical evidence in the last decade has implicated TMAO as an important contributor to the pathogenesis of cardiovascular diseases.
Saravanan Subramaniam, Craig Fletcher
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Microbiome, trimethylamine N-oxide, and cardiometabolic disease [PDF]
Translational Research, 2017 There is increasing appreciation that changes in microbiome composition and function can promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites that are biologically active, such as trimethylamine N-oxide (TMAO), are now recognized as contributors to atherogenesis.
W.H. Wilson Tang, Stanley L. Hazen
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Influence of Trimethylamine N-Oxide on Platelet Activation
Nutrients, 2022 Microbiome-derived trimethylamine N-oxide (TMAO) has been associated with platelet hyperreactivity and subsequent atherogenesis. Whether physiological TMAO-levels influence platelet-derived lipid mediators remains unknown. Little is known about pre-analytic factors potentially influencing TMAO concentrations. We aimed at developing a quantitative LC-MS/
Emonds, Julian Josef +7 more
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Trimethylamine-N-Oxide and Heart Failure
Journal of the American College of Cardiology, 2015 The new study by Tang et al. [(1)][1] demonstrating an inverse correlation of serum levels of trimethylamine- N -oxide (TMAO) with survival in patients with heart failure (HF) is intriguing and thought provoking. Similar findings have been published recently by Norwegian researchers.
McCarty, Mark F. +1 more
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Impact of trimethylamine-N-oxide (TMAO) plasma levels and acute ischemic stroke (AIS) risk.
, 2023 Impact of trimethylamine-N-oxide (TMAO) plasma levels and acute ischemic stroke (AIS) risk.
Nianqiu Liu (17290684) +7 more
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Atherosclerosis and trimethylamine-N-oxide — the gut microbiota potential
, 2022 Gut dysbiosis contribute to the development of atherosclerosis. Firmicutes contain a trimethylamine-producing gene cluster. The aim was to analyze potential role of trimethylamine-N-oxide (TMAO), gut microbiota metabolite, in the pathogenesis of ...
I. N. Grigorieva
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