Results 11 to 20 of about 553,444 (284)

Trimethylamine N-oxide in atrial fibrillation progression

International Journal of Cardiology: Heart & Vasculature, 2020
The human gut microbiome and its metabolite Trimethylamine N-oxide (TMAO) are sensitive to the human diet and are involved in the complex pathomechanisms that underpin diabetes, obesity, and cardiovascular diseases.
Petra Büttner, Jürgen G. Okun, Jana Hauke, Erik Holzwirth, Danilo Obradovic, Gerhard Hindricks, Holger Thiele, Jelena Kornej   +7 more
doaj   +3 more sources

Trimethylamine N-oxide—a marker for atherosclerotic vascular disease [PDF]

Reviews in Cardiovascular Medicine, 2021
As a potential causative factor in various cardiovascular diseases, the gut microbe-generated metabolite trimethylamine N-oxide (TMAO) has courted considerable research interest as a potential biomarker.
Guinan Xie, An Yan, Peng Lin, Yi Wang, Liping Guo   +4 more
doaj   +3 more sources

Porphyromonas gingivalis drives trimethylamine-N-oxide accumulation via modulation of gut microbial trimethylamine lyase in mice [PDF]

Frontiers in Microbiology
IntroductionTrimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, is linked to cardiovascular, neurodegenerative, and metabolic diseases. Emerging evidence indicates a bidirectional interaction between the periodontal pathogen Porphyromonas
Weige Xie, Dong Han, Jinlu Tan, Dan Zhao, Jingwen Dong, Juan Wu, Xuebin Yang, Sijing Xie   +7 more
doaj   +2 more sources

Gut microbes impact stroke severity via the trimethylamine N-oxide pathway

Cell Host and Microbe, 2021
Clinical studies have demonstrated associations between circulating levels of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk.
Weifei Zhu, Naseer Sangwan, Xinmin S Li
exaly   +2 more sources

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Journal of the American Heart Association, 2016
The choline‐derived metabolite trimethylamine N‐oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk.
Marcus M Seldin, Weifei Zhu, Zeneng Wang
exaly   +2 more sources

Role of Trimethylamine N-Oxide in Heart Failure

Reviews in Cardiovascular Medicine
Heart failure (HF) is a clinical syndrome characterizing by typical physical signs and symptomatology resulting from reduced cardiac output and/or intracardiac pressure at rest or under stress due to structural and/or functional abnormalities of the ...
Lele Jing, Honghong Zhang, Qiannan Xiang, Huilin Hu, Changlin Zhai, Suining Xu, Hongen Tian   +6 more
doaj   +3 more sources

The microbial metabolite trimethylamine N-oxide and the kidney diseases [PDF]

Frontiers in Cellular and Infection Microbiology
Trimethylamine N-oxide (TMAO), a metabolite, is a co-metabolite produced by both gut microbiota and livers, originating from foods rich in choline or carnitine.
Jin-Qi Su, Jin-Qi Su, Xiang-Qi Wu, Xiang-Qi Wu, Qi Wang, Qi Wang, Bo-Yang Xie, Bo-Yang Xie, Cui-Yan Xiao, Cui-Yan Xiao, Hong-Yong Su, Hong-Yong Su, Ji-Xin Tang, Ji-Xin Tang, Cui-Wei Yao, Cui-Wei Yao   +15 more
doaj   +2 more sources

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

Cell Metabolism, 2013
Brian J Bennett, Zeneng Wang, Hooman Allayee   +2 more
exaly   +2 more sources

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia

Alzheimer’s Research & Therapy
Background The gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnitine – have been associated with an increased risk of cardiovascular disease, but their relation to cognition ...
Amber Yaqub, Dina Vojinovic, Meike W. Vernooij, P. Eline Slagboom, Mohsen Ghanbari, Marian Beekman, Jeroen van der Grond, Thomas Hankemeier, Cornelia M. van Duijn, M. Arfan Ikram, Shahzad Ahmad   +10 more
doaj   +5 more sources

Trimethylamine N-Oxide as a Potential Biomarker for Cardiovascular Disease: Its Association with Dietary Sources of Trimethylamine N-Oxide and Microbiota

Eurasian Journal of Medicine, 2023
Trimethylamine N-oxide (TMAO), the oxidized form of trimethylamine (TMA), was previously thought to be a waste product but is now considered an important risk factor for cardiovascular disease (CVD) and its comorbidities. Foods or supplements containing
Yasemin Karaagac
doaj   +1 more source