Atherosclerosis and trimethylamine-N-oxide — the gut microbiota potential
Российский кардиологический журнал, 2022 Gut dysbiosis contribute to the development of atherosclerosis. Firmicutes contain a trimethylamine-producing gene cluster. The aim was to analyze potential role of trimethylamine-N-oxide (TMAO), gut microbiota metabolite, in the pathogenesis of ...
I. N. Grigorieva
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Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA) Determinations of Two Hadal Amphipods
Journal of Marine Science and Engineering, 2022 Hadal trenches are a unique habitat with high hydrostatic pressure, low temperature and scarce food supplies. Amphipods are the dominant scavenging metazoan species in this ecosystem.
Qi Liu +4 more
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Trimethylamine N-oxide in cardiovascular disease
Advances in Clinical and Experimental Medicine, 2022 Although traditional cardiovascular risk factors are well established and understood, mortality and morbidity in patients with cardiovascular disease (CVD) remains high. Exploring new pathophysiological pathways enables a better understanding of CVD at both the molecular and clinical levels.
Radoslaw Konieczny, Wiktor Kuliczkowski
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Fecal Microbiome Composition Does Not Predict Diet‐Induced TMAO Production in Healthy Adults
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Trimethylamine‐N‐oxide (TMAO) is a small molecule derived from the metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease. Plasma TMAO increases following consumption of red meat.
Marc Ferrell +11 more
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Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
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Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide [PDF]
Journal of Stroke, 2019 Trimethylamine N-oxide (TMAO) is produced when trimethylamine, a waste product of gut microbes, is converted via hepatic flavin monooxygenases. As TMAO is a potential causative factor in various cardiovascular diseases (CVDs) considerable research ...
Hyo Suk Nam
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Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke
Frontiers in Neurology, 2023 Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly ...
Yuan Liu +6 more
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Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]
, 2013 Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A +6 more
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Trimethylamine N‐oxide: breathe new life [PDF]
British Journal of Pharmacology, 2017 Association between elevated levels of systemic trimethylamine N‐oxide (TMAO) and increased risk for adverse cardiovascular events have been proposed in recent years. Increasing experimental and clinical evidence in the last decade has implicated TMAO as an important contributor to the pathogenesis of cardiovascular diseases.
Saravanan Subramaniam, Craig Fletcher
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Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease [PDF]
, 2016 Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeutic drugs. However, on a daily basis we are exposed to one of the most abundant substrates of the enzyme, trimethylamine, which is released ...
Fennema, D, Phillips, IR, Shephard, EA
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