Results 41 to 50 of about 553,444 (284)

Influence of Trimethylamine N-Oxide on Platelet Activation

Nutrients, 2022
Microbiome-derived trimethylamine N-oxide (TMAO) has been associated with platelet hyperreactivity and subsequent atherogenesis. Whether physiological TMAO-levels influence platelet-derived lipid mediators remains unknown. Little is known about pre-analytic factors potentially influencing TMAO concentrations. We aimed at developing a quantitative LC-MS/
Emonds, Julian Josef, Ringel, Clemens, Reinicke, Madlen, Müller, Daniel, Von Eckardstein, Arnold, Meixensberger, Jürgen, Ceglarek, Uta, Gaudl, Alexander   +7 more
openaire   +3 more sources

Prebiotic, Probiotic, and Synbiotic Supplementation in Chronic Kidney Disease: A Systematic Review and Meta-analysis [PDF]

, 2019
Gut dysbiosis has been implicated in the pathogenesis of chronic kidney disease (CKD). Restoring gut microbiota with prebiotic, probiotic, and synbiotic supplementation has emerged as a potential therapeutic intervention but has not been systematically ...
Campbell, Katrina L., Johnson, David W., McFarlane, Catherine, Ramos, Christiane I.   +3 more
core   +1 more source

Trimethylamine N-oxide and kidney diseases: what do we know?

Brazilian Journal of Nephrology, 2023
In the human gut, there is a metabolically active microbiome whose metabolic products reach various organs and are used in the physiological activities of the body.
Ozkan Gungor, Nuri Baris Hasbal, Demet Alaygut   +2 more
doaj   +2 more sources

A New Light on Vitamin D in Obesity: A Novel Association with Trimethylamine-N-Oxide (TMAO) [PDF]

, 2019
: Vitamin D deficiency and obesity are two public health problems extensively exacerbated over the last years. Among the several mechanisms proposed to account for the complex interplay between vitamin D and obesity, one that has gained particular ...
Annunziata, G., Barrea, L., Colao, A., de Alteriis, G., Laudisio, D., Muscogiuri, G., Savastano, S., Tenore, G. C.   +7 more
core   +1 more source

Assessing hepatic metabolic changes during progressive colonization of germ-free mouse by 1H NMR spectroscopy [PDF]

, 2011
It is well known that gut bacteria contribute significantly to the host homeostasis, providing a range of benefits such as immune protection and vitamin synthesis.
Claus, Sandrine, Heath, Peter
core   +1 more source

Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF) [PDF]

, 2018
Aims: Association of elevated circulating levels of trimethylamine N-oxide (TMAO) with adverse outcomes in patients with heart failure (HF) has been described.
Anker, Stefan D., Chan, Daniel C. S., Cleland, John G. F., Dickstein, Kenneth, Filippatos, Gerasimos S., Hillege, Hans L., Jones, Donald J. l., Lang, Chim C., Metra, Marco, Ng, Leong Loke, Ponikowski, Peter, Samani, Nilesh J., Suzuki, Toru, van Veldhuisen, Dirk Jan, Voors, Adriaan A., Yazaki, Yoshiyuki, Zannad, Faiez, Zwinderman, Aeilko H.   +17 more
core   +4 more sources

Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

mBio, 2016
The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action remain unclear.
Ming‐liang Chen, Long Yi, Yong Zhang, Xi Zhou, Li Ran, Jining Yang, Jun‐dong Zhu, Qian‐yong Zhang, M. Mi   +8 more
semanticscholar   +1 more source

Trimethylamine-N-Oxide and Heart Failure

Journal of the American College of Cardiology, 2015
The new study by Tang et al. [(1)][1] demonstrating an inverse correlation of serum levels of trimethylamine- N -oxide (TMAO) with survival in patients with heart failure (HF) is intriguing and thought provoking. Similar findings have been published recently by Norwegian researchers.
McCarty, Mark F., DiNicolantonio, James J.   +1 more
openaire   +2 more sources

TMAO metaorganismal pathway and chronic inflammatory diseases [PDF]

Exploration of Medicine
Nutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA.
Zeneng Wang, Shumei Man, Robert Koeth
doaj   +1 more source

Trimethylamine-N-oxide (TMAO) as novel potential biomarker of early predictors of metabolic syndrome [PDF]

, 2018
There is a mechanistic link between the gut-derived metabolite trimethylamine-N-oxide (TMAO) and obesity-related diseases, suggesting that the TMAO pathway may also be linked to the pathogenesis of obesity.
Annunziata, Giuseppe, Barrea, Luigi, Colao, Annamaria, de Alteriis, Giulia, Di Somma, Carolina, Laudisio, Daniela, Maisto, Maria, Muscogiuri, Giovanna, Savastano, Silvia, Tenore, Gian Carlo   +9 more
core   +2 more sources