Results 41 to 50 of about 19,127 (154)
Relationship between red meat metabolite trimethylamine N-oxide and cardiovascular disease
Heart and Mind, 2022 Many cardiovascular diseases (CVD) are caused by the interplay of lifestyle and genetic factors. Studies have suggested an association between red meat consumption and increased CVD risk. There is evidence indicating that trimethylamine N-oxide (TMAO), a
Angatu Yousuf, David G McVey, Shu Ye
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mSystems, 2021 The gut microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) is linked to an increased risk for cardiovascular diseases. Trimethylamine (TMA), which is subsequently oxidized to TMAO in the liver, is formed by intestinal bacteria via distinct ...
Silke Rath +11 more
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Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension
Redox Biology, 2021 Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis.
Shan Jiang +19 more
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The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. [PDF]
PLoS ONE, 2016 UNLABELLED:The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.
Ruben Poesen +8 more
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Diabetes, Metabolic Syndrome and Obesity, 2023 Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
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Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction
Cellular Physiology and Biochemistry, 2017 Background/Aim: Plasma trimethylamine-N-oxide (TMAO), a product of intestinal microbial metabolism of dietary phosphatidylcholine has been recently associated with atherosclerosis and increased risk of cardiovascular diseases (CVD) in rodents and humans.
Krishna M. Boini +3 more
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Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase
eLifeSubstrate channeling enhances efficiency and prevents toxicity by directing unstable intermediates between active sites. Trimethylamine N-oxide demethylase (TDM) degrades trimethylamine N-oxide (TMAO) to dimethylamine and formaldehyde (HCHO), but the ...
Trung Thach +7 more
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Research advances of trimethylamine N-oxide and chronic kidney diseases
Linchuang shenzangbing zazhi, 2021 Trimethylamine N-oxide（TMAO）is an important gut microbiota-dependent metabolite.Currently many clinical studies have confirmed the correlation between TMAO and the prognosis of chronic kidney disease（CKD）patients.This review summarized the latest ...
Liu Mei-jun +3 more
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Pressing the trimethylamine N-oxide narrative
AME Medical Journal, 2017 We read with interest the correspondence titled “Gut Microbe-Generated Trimethylamine N-Oxide from Dietary Choline is Prothrombotic in Subjects”, published by Zhu et al . in the journal Circulation (1). This work builds on an emerging body of evidence which has suggested a role for the gut-derived metabolite, trimethylamine N -oxide (TMAO), in the ...
Kevin C. Klatt, Marie A. Caudill
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Clinical Interventions in Aging, 2021 Rui Huang,1,* Li Yan,2,* Yuhua Lei1 1Cardiovascular Disease Center, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi Prefecture, 445000, Hubei Province, People’s Republic of China ...
Huang R, Yan L, Lei Y
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