Results 51 to 60 of about 11,163,062 (259)

Trimethylamine N-Oxide as a Novel Therapeutic Target in CKD [PDF]

Journal of the American Society of Nephrology, 2016
Patients with CKD are at an increased risk for the development of cardiovascular disease even beyond traditional risk factors. Although uremic toxins have been proposed as important contributors in the pathogenesis of cardiovascular and renal disease progression in CKD, the sources and the ...
openaire   +2 more sources

The Fate of Trimethylamine Oxide and Trimethylamine in Man

, 1941
Normal human urine contains small amounts of trimethylamine oxide but no appreciable trimethylamine. Trimethylamine when administered orally appears mainly as trimethylamine oxide in the urine; trimethylamine oxide similarly administered is excreted ...
H. L. A. Tarr
core   +1 more source

Body‐integrated photonic biosensors: Illuminating the path to active healthcare

FlexMat, EarlyView.
Body‐integrated photonic biosensors are promising tools for active healthcare. These optical devices can be worn, implanted, or swallowed to monitor health signals continuously. This review introduces key sensing modalities, including fluorescence, colorimetry, SPR, LSPR, SERS, and light‐modulating materials.
Jiayue Gu, Xingming Wen, Qihang Yan, Yining Zhao, Linghao Yuan, Siyuan Chen, Yue Ma, Zhengyue Fang, Dong Lei, Yuxin Liu, Ze Xiong   +10 more
wiley   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Replica of a Fishy Enzyme: Structure–Function Analogue of Trimethylamine-N-Oxide Reductase

, 2016
Three new complexes, [MoIVO­(mnt)­(SS)]2‑ (SS = dimethylethylenedicarboxylate (DMED), toluenedithiolate (tdt), benzenedithiolate (bdt); mnt = maleonitriledithiolate), each possessing two different dithiolene ligands, are synthesized as model of ...
Golam Moula (1862872), Moumita Bose (1862875), Sabyasachi Sarkar (1705045)   +2 more
core   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Trimethylamine-N-oxide-induced folding of α-synuclein

, 2001
The effect of the natural osmolyte trimethylamine-N-oxide (TMAO) on the structural properties and fibril formation of the natively unfolded protein human α-synuclein was studied using several physico-chemical methods. TMAO induced folding of α-synuclein:
Fink, Anthony L., Uversky, Vladimir N., Li, Jie, Anthony L. Fink, Jie Li, Vladimir N. Uversky   +5 more
core   +1 more source

Literature search and study selection process for inclusion in meta-analysis of trimethylamine-N-oxide (TMAO) and the risk of acute ischemic stroke (AIS).

, 2023
Literature search and study selection process for inclusion in meta-analysis of trimethylamine-N-oxide (TMAO) and the risk of acute ischemic stroke (AIS).
Nianqiu Liu (17290684), Qiuyue Xu (8931536), Ya Li (194567), Zaidie Sun (17290681), Kai Yang (73590), Yong Duan (151342), Yuan Hong (413401), Zhangyou Guo (15444468)   +7 more
core   +1 more source

Second‐trimester multimetabolite panel for early preeclampsia rule‐out

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective We aimed to establish a high‐sensitivity, multimetabolite rule‐out model for the development of preeclampsia (PE), prioritizing minimizing false negatives to exclude low‐risk individuals from intensive surveillance confidently. Methods In this prospective, nested case–control study, maternal serum samples were collected between 20+0 ...
Matthews Silva Martins, Julyane N. S. Kaihara, Diego Fortes Salgueiro, Viviane Cunha Cardoso, Silvana Maria Quintana, Ricardo Carvalho Cavalli, Valerio Garrone Barauna, Valeria Cristina Sandrim   +7 more
wiley   +1 more source

Replica of a fishy enzyme: structure–function analogue of trimethylamine-N-oxide reductase

, 2013
Three new complexes, [MoIVO(mnt)(SS)]2- (SS = dimethylethylenedicarboxylate (DMED), toluenedithiolate (tdt), benzenedithiolate (bdt); mnt = maleonitriledithiolate), each possessing two different dithiolene ligands, are synthesized as model of ...
Bose, Moumita, Moula, Golam, Sarkar, Sabyasachi   +2 more
core   +1 more source