Results 51 to 60 of about 19,127 (154)

Association between plasma trimethylamine N-oxide level and atrial fibrillation [PDF]

Jichu yixue yu linchuang
Objective To explore the relationship between plasma trimethylamine N-oxide(TMAO) level and atrial fibrillation(AF) by a clinical trial. Methods Totally 257 patients with AF were enrolled including 114 patients with paroxysmal AF and 143 with ...
YANG Wentao, ZHAO Qing, LI Xiangdong, WANG Yutang, LIU Wei
doaj   +1 more source

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

Microbiome, 2018
Background The dietary methylamines choline, carnitine, and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA).
Lesley Hoyles, Maria L. Jiménez-Pranteda, Julien Chilloux, Francois Brial, Antonis Myridakis, Thomas Aranias, Christophe Magnan, Glenn R. Gibson, Jeremy D. Sanderson, Jeremy K. Nicholson, Dominique Gauguier, Anne L. McCartney, Marc-Emmanuel Dumas   +12 more
doaj   +1 more source

Trimethylamine-N-oxide is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis

Renal Failure, 2020
Background Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary l-carnitine and choline, cleared by the kidney, has been implicated in the ...
Yin Zheng, Zihui Tang, Li You, Yuanhao Wu, Junfeng Liu, Jun Xue   +5 more
doaj   +1 more source

Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxide. [PDF]

PLoS ONE, 2017
Without a glucocorticoid (GC) ligand, the transcription factor glucocorticoid receptor (GR) is largely cytoplasmic, with its GC-binding domain held in high affinity conformation by a cluster of chaperones.
Aaron L Miller, W Austin Elam, Betty H Johnson, Shagufta H Khan, Raj Kumar, E Brad Thompson   +5 more
doaj   +1 more source

Trimethylamine N-Oxide as a Novel Therapeutic Target in CKD [PDF]

Journal of the American Society of Nephrology, 2016
Patients with CKD are at an increased risk for the development of cardiovascular disease even beyond traditional risk factors. Although uremic toxins have been proposed as important contributors in the pathogenesis of cardiovascular and renal disease progression in CKD, the sources and the ...
openaire   +2 more sources

The food-derived metabolite trimethylamine and trimethylamine-N-oxide promote colorectal cancer progression via SREBF1

Ecotoxicology and Environmental Safety
Colorectal cancer (CRC) is characterised by microbial dysbiosis. Trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) are gut microbiota-derived metabolites produced from dietary precursors that are implicated in CRC progression.
Yang Yan, Jiaxuan Li, Hejia Xu, Chen Yang, Guifang Li, Yanyan Feng, Qian Wang, Li Li, Rendi Wu, Hairong Sun, Ting Zhang, Fang Wang, Yong Mao   +12 more
doaj   +1 more source

Trimethylamine N‐Oxide and Mortality Risk in Patients With Peripheral Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundProduction of the proatherogenic metabolite, trimethylamine N‐oxide (TMAO), from dietary nutrients by intestinal microbiota enhances atherosclerosis development in animal models and is associated with atherosclerotic coronary artery disease in ...
Vichai Senthong, Zeneng Wang, Yiying Fan, Yuping Wu, Stanley L. Hazen, W. H. Wilson Tang   +5 more
doaj   +1 more source

Gut Microbe-Generated Metabolite Trimethylamine-N-Oxide and Ischemic Stroke

Biomolecules
Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite, the production of which in vivo is mainly regulated by dietary choices, gut microbiota, and the hepatic enzyme flavin monooxygenase (FMO), while its elimination occurs via the kidneys.
Zhen Li, Xinyi He, Qi Fang, Xulong Yin
doaj   +1 more source

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

Nature Communications
β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes could directly decrease glucose-stimulated insulin secretion (GSIS) in MIN6 ...
Lijuan Kong, Qijin Zhao, Xiaojing Jiang, Jinping Hu, Qian Jiang, Li Sheng, Xiaohong Peng, Shusen Wang, Yibing Chen, Yanjun Wan, Shaocong Hou, Xingfeng Liu, Chunxiao Ma, Yan Li, Li Quan, Liangyi Chen, Bing Cui, Pingping Li   +17 more
doaj   +1 more source

Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome

Frontiers in Physiology, 2019
Background/Aims: Gut microbiota has been reported to correlate with a higher mortality and worse prognosis of cardiovascular diseases. Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of specific dietary nutrients, which is linked ...
Xueling Li, Jin Geng, Jinxuan Zhao, Qianqian Ni, Chenze Zhao, Yaru Zheng, Xiaomin Chen, Lihong Wang   +7 more
doaj   +1 more source