Results 1 to 10 of about 12,371 (198)

Involvement of trimethylamine N-oxide in major depressive disorder via astrocytic d-Serine dysregulation [PDF]

Neurotherapeutics
Trimethylamine N-oxide (TMAO), a co-metabolite of the gut microbiota and host, has been implicated in the pathogenesis of various neuropsychiatric disorders. However, its role in major depressive disorder (MDD) remains poorly understood.
Liwang Lin, Longyu Li, Shiao Ren, Liping Liu, Ying Liu, Wenlei Zhang, Zengliang Gao, Xiaoting Ni, Haoxuan Li, Xinsheng Duan, Sijing Tao, Tianyu Zhao, Xin Hai   +12 more
doaj   +2 more sources

Background Diet Influences TMAO Concentrations Associated with Red Meat Intake without Influencing Apparent Hepatic TMAO-Related Activity in a Porcine Model

Metabolites, 2020
Red meat has been associated with an increased cardiovascular disease (CVD) risk, possibly through gut microbial-derived trimethylamine-N-oxide (TMAO).
Hanne Christine Bertram, Martin Krøyer Rasmussen, Thomas Van Hecke   +2 more
exaly   +3 more sources

Lactobacilli and Bifidobacterium as anti- atherosclerotic agents [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Atherosclerosis is the thickening or hardening of the arteries which is caused by a buildup of atheromatous plaque in the inner lining of an artery. Hypercholesterolemia, inflammation, oxidative stress, and trimethylamine N-oxide (TMAO) are important ...
Milad Abdi, Hadi Esmaeili Gouvarchin Ghaleh, Reza Ranjbar   +2 more
doaj   +1 more source

Sex-specific differences in trimethylamine N-oxide (TMAO) concentrations before and after cardiac rehabilitation in acute myocardial infarction patients

EXCLI Journal : Experimental and Clinical Sciences, 2022
Trimethylamine N-oxide (TMAO) is a biomarker of cardiovascular risk and may enhance the progression of atherosclerosis. The aim of the study was to determine whether there are sex-specific differences in TMAO concentrations before and after cardiac ...
Andreas Baranyi, Andreas Meinitzer, Dirk von Lewinski, Hans-Bernd Rothenhäusler, Omid Amouzadeh-Ghadikolai, Hanns Harpf, Leonhard Harpf, Heimo Traninger, Ronald Hödl, Birgit M. Harb, Barbara Obermayer-Pietsch, Melanie Schweinzer, Celine K. Braun, Dietmar Enko   +13 more
doaj   +1 more source

TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

eLife, 2020
Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS).
Marta Gawrys-Kopczynska, Marek Konop, Klaudia Maksymiuk, Katarzyna Kraszewska, Ladislav Derzsi, Krzysztof Sozanski, Robert Holyst, Marta Pilz, Emilia Samborowska, Leszek Dobrowolski, Kinga Jaworska, Izabella Mogilnicka, Marcin Ufnal   +12 more
doaj   +1 more source

Finding small molecular compounds to decrease trimethylamine oxide levels in atherosclerosis by virtual screening

Open Chemistry, 2023
The intestinal microbial metabolite trimethylamine oxide (TMAO) affects the formation and development of atherosclerosis (AS). The design and development of an effective targeted drug to reduce serum TMAO levels may provide new avenues for inhibiting AS ...
Luo Jiaxin, Zhang Aoqi, Yao Yuan, Yuan Jun   +3 more
doaj   +1 more source

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

JCI Insight, 2023
We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes inflammation via trained immunity (TI).
Fatma Saaoud, Lu Liu, Keman Xu, Ramon Cueto, Ying Shao, Yifan Lu, Yu Sun, Nathaniel W. Snyder, Sheng Wu, Ling Yang, Yan Zhou, David L. Williams, Chuanfu Li, Laisel Martinez, Roberto I. Vazquez-Padron, Huaqing Zhao, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +18 more
doaj   +1 more source

Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation

Nutrition & Metabolism, 2021
Background Trimethylamine-N-oxide (TMAO) is an independent risk factor for atherosclerosis. Consumption of hawthorn fruit is believed to be cardio-protective, yet whether it is able to suppress the TMAO-induced atherosclerosis remains unexplored.
Zouyan He, Erika Kwek, Wangjun Hao, Hanyue Zhu, Jianhui Liu, Ka Ying Ma, Zhen-Yu Chen   +6 more
doaj   +1 more source

Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome

Molecules, 2023
TMAO is a new risk biomarker for cardiovascular disease. With trimethylammonium as its main chemical skeleton, TMAO is structurally similar to many endogenous metabolites, such as acetylcholine, carnitine, phosphorylcholine, etc. The mechanism of TMAO on
Dongyu Lei, Wenbo Yu, Yi Liu, Yujie Jiang, Xiaohui Li, Jing Lv, Ying Li   +6 more
doaj   +1 more source

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Redox Biology, 2021
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis.
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng   +19 more
doaj   +1 more source