Results 41 to 50 of about 16,874 (230)

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine.
Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer   +8 more
doaj   +1 more source

Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2. [PDF]

Environmental microbiology, 2014
Methylocella silvestris, an alphaproteobacterium isolated from a forest soil, can grow on trimethylamine N-oxide (TMAO) as a sole nitrogen source; however, the molecular and biochemical mechanisms underpinning its growth remain unknown. Marker-exchange mutagenesis enabled the identification of several genes involved in TMAO metabolism, including ...
Zhu, Yijun , Jameson, Eleanor, Parslow, Rosemary A., Lidbury, Ian, Fu, Tiantian, Dafforn, Tim, Schäfer, Hendrik, Chen, Yin   +7 more
openaire   +2 more sources

Paradox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients

Journal of Intensive Care, 2021
Background Trimethylamine N-oxide (TMAO) is a microbiota-derived metabolite, which is linked to vascular inflammation and atherosclerosis in cardiovascular (CV) diseases. But its effect in infectious diseases remains unclear. We conducted a single-center
Ruey-Hsing Chou, Po-Shan Wu, Shen-Chih Wang, Cheng-Hsueh Wu, Shu-Fen Lu, Ru-Yu Lien, Yi-Lin Tsai, Ya-Wen Lu, Ming-Ren Kuo, Jiun-Yu Guo, Ruey-Yi Chou, Po-Hsun Huang, Shing-Jong Lin   +12 more
doaj   +1 more source

Relationship between Plasma Trimethylamine N-Oxide Levels and Renal Dysfunction in Patients with Hypertension

Kidney & Blood Pressure Research, 2021
Introduction: Trimethylamine N-oxide (TMAO) is a metabolite produced by gut bacteria. Although increased TMAO levels have been linked to hypertension (HTN) and chronic kidney disease (CKD) with poor prognosis, no clinical studies have directly addressed ...
Jia Zhou, Dingkun Wang, Bingong Li, Xuelian Li, Xingjun Lai, Shufang Lei, Na Li, Xuting Zhang   +7 more
doaj   +1 more source

Implications of trimethylamine N-oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds

Frontiers in Molecular Biosciences, 2022
Osmolytes are naturally occurring small molecular weight organic molecules, which are accumulated in large amounts in all life forms to maintain the stability of cellular proteins and hence preserve their functions during adverse environmental conditions.
Andrew Ilyas, Y. Wijayasinghe, I. Khan, Nourhan M. El Samaloty, M. Adnan, T. Dar, N. Poddar, L. Singh, Hemlata Sharma, Shahanavaj Khan   +9 more
semanticscholar   +1 more source

Atherosclerosis and trimethylamine-N-oxide — the gut microbiota potential

Российский кардиологический журнал, 2022
Gut dysbiosis contribute to the development of atherosclerosis. Firmicutes contain a trimethylamine-producing gene cluster. The aim was to analyze potential role of trimethylamine-N-oxide (TMAO), gut microbiota metabolite, in the pathogenesis of ...
I. N. Grigorieva
doaj   +1 more source

Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis

Frontiers in Immunology, 2022
Liver fibrosis is one main histological characteristic of nonalcoholic steatohepatitis (NASH), a disease paralleling a worldwide surge in metabolic syndromes with no approved therapies.
Dengcheng Zhou, Jing Zhang, Chengju Xiao, C. Mo, B. Ding   +4 more
semanticscholar   +1 more source

Trimethylamine-N-oxide (TMAO) increased aquaporin-2 expression in spontaneously hypertensive rats

Clinical and Experimental Hypertension, 2019
Recent evidence suggests that elevated plasma levels of Trimethylamine-N-oxide (TMAO) can prolong the duration of elevated blood pressure in rats. The purpose of this study was to investigate the plasma TMAO level in Spontaneously Hypertensive Rats (SHR)
Min Liu, Qinghua Han, Jinglu Yang
doaj   +1 more source

Trimethylamine N-oxide in atrial fibrillation progression

International Journal of Cardiology: Heart & Vasculature, 2020
The human gut microbiome and its metabolite Trimethylamine N-oxide (TMAO) are sensitive to the human diet and are involved in the complex pathomechanisms that underpin diabetes, obesity, and cardiovascular diseases.
Petra Büttner, Jürgen G. Okun, Jana Hauke, Erik Holzwirth, Danilo Obradovic, Gerhard Hindricks, Holger Thiele, Jelena Kornej   +7 more
doaj   +1 more source

Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health

Metabolites
The intestinal microbiota, hosting trillions of microorganisms that inhabit the gastrointestinal tract, functions as a symbiotic organism that plays a crucial role in regulating health by producing biologically active molecules that can enter systemic ...
E. Caradonna, Federico Abate, Elisabetta Schiano, Francesca Paparella, F. Ferrara, Emilio Vanoli, Rossana Difruscolo, Vito Maria Goffredo, Bruno Amato, Carlo Setacci, F. Setacci, Ettore Novellino   +11 more
semanticscholar   +1 more source