Results 41 to 50 of about 16,933 (236)

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Diabetes, Metabolic Syndrome and Obesity, 2023
Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
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Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure

Frontiers in Cell and Developmental Biology, 2021
Aim: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite synthesized in host organisms from specific food constituents, such as choline, carnitine and betaine. During the last decade, elevated TMAO levels have been proposed as biomarkers
Melita Videja, Melita Videja, Reinis Vilskersts, Reinis Vilskersts, Stanislava Korzh, Helena Cirule, Eduards Sevostjanovs, Maija Dambrova, Maija Dambrova, Marina Makrecka-Kuka   +9 more
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Unraveling the metabolic pathway of choline-TMA-TMAO: Effects of gypenosides and implications for the therapy of TMAO related diseases

Pharmacological Research, 2021
Trimethylamine-N-oxide (TMAO) has emerged as a promising new therapeutic target for the treatment of central nervous system diseases, atherosclerosis and other diseases. However, its origin in the brain is unclear. Gynostemma pentaphyllum (Thunb.) Makino can reduce the increase of TMAO level caused by a high fat diet.
Qiao Zhang, Xiaomin Guo, Cao Xie, Zhonglian Cao, Xin Wang, Li Liu, Ping Yang   +6 more
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Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice [PDF]

, 2021
Patients with chronic kidney disease (CKD) have elevated circulating levels of trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with cardiovascular diseases.
Karolina Elżbieta Kaczor-Urbanowicz, Zhang, Wenchao, Wenchao Zhang, Kaczor-Urbanowicz, Karolina Elżbieta, Guo, Fangfei, Magyar, Clara, Matteo Pellegrini, Sarada Charugundla, Zeneng Wang, Aika Miikeda, Zhiqiang Zhou, Xun Jia, Zhou, Zhiqiang, Jia, Xun, Diana M. Shih, Zuckerman, Jonathan, Pellegrini, Matteo, Wang, Zeneng, Shih, Diana M, Lusis, Aldons J, Hazen, Stanley L, Susanne B. Nicholas, Stanley L. Hazen, Nicholas, Susanne B, Charugundla, Sarada, Miikeda, Aika, Clara Magyar, Fangfei Guo, Aldons J. Lusis, Jonathan Zuckerman   +29 more
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Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine.
Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer   +8 more
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Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease [Corrigendum]

Clinical Interventions in Aging, 2021
He W, Luo Y, Liu JP, et al. Clin Interv Aging. 2020;15:1809– 1820. The authors have advised affiliation 2 on page 1809 is incorrect, the text “Peking Union Medical College” should read “Graduate School of Peking Union ...
He W, Luo Y, Liu JP, Sun N, Guo D, Cui LL, Zheng PP, Yao SM, Yang JF, Wang H   +9 more
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Additional file 1 of The associations between TMAO-related metabolites and blood lipids and the potential impact of rosuvastatin therapy

, 2022
Additional file 1: Figure S1. The associations between the TMAO-related metabolites and personal characteristics (n = 112). Table S1. Baseline characteristics of patients without prior statin therapy (Group 1) and patients who received irregular statin ...
Shaobin Wei (10671360), Shenghua Yang (3308832), Jian Zhou (28020), Xiaowei Xiong (3561863), Qiang Fu (129583), Xiaowei Xu (82471), Buxing Chen (4244242)   +6 more
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Paradox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients

Journal of Intensive Care, 2021
Background Trimethylamine N-oxide (TMAO) is a microbiota-derived metabolite, which is linked to vascular inflammation and atherosclerosis in cardiovascular (CV) diseases. But its effect in infectious diseases remains unclear. We conducted a single-center
Ruey-Hsing Chou, Po-Shan Wu, Shen-Chih Wang, Cheng-Hsueh Wu, Shu-Fen Lu, Ru-Yu Lien, Yi-Lin Tsai, Ya-Wen Lu, Ming-Ren Kuo, Jiun-Yu Guo, Ruey-Yi Chou, Po-Hsun Huang, Shing-Jong Lin   +12 more
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Relationship between Plasma Trimethylamine N-Oxide Levels and Renal Dysfunction in Patients with Hypertension

Kidney & Blood Pressure Research, 2021
Introduction: Trimethylamine N-oxide (TMAO) is a metabolite produced by gut bacteria. Although increased TMAO levels have been linked to hypertension (HTN) and chronic kidney disease (CKD) with poor prognosis, no clinical studies have directly addressed ...
Jia Zhou, Dingkun Wang, Bingong Li, Xuelian Li, Xingjun Lai, Shufang Lei, Na Li, Xuting Zhang   +7 more
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TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function [PDF]

Scientific Reports, 2017
AbstractTrimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function.
Eke G. Gruppen, Erwin Garcia, Margery A. Connelly, Elias J. Jeyarajah, James D. Otvos, Stephan J. L. Bakker, Robin P. F. Dullaart   +6 more
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