Results 61 to 70 of about 16,933 (236)
Entropic Stabilization of Proteins by TMAO
, 2016 The osmolyte trimethylamine N-oxide (TMAO) accumulates in the cell in response to osmotic stress and increases the thermodynamic stability of folded proteins.
D. Thirumalai (1277850) +3 more
core +1 more source
A study of the interaction between TMAO and urea in water using NMR spectroscopy [PDF]
, 2022 Trimethylamine N-oxide (TMAO) and urea are small organic biological molecules. While TMAO is known as a protective osmolyte that promotes the native form of biomolecules, urea is a denaturant.
Ries, ME +9 more
core +1 more source
Gut Microbiota Dysbiosis and Metabolite Pathways in Heart Failure: A Systematic Review
Journal of Pure and Applied MicrobiologyThe gut microbiome plays a critical role in heart failure (HF) through immune, metabolic, and inflammatory pathways. Altered microbial composition and metabolites may contribute to HF pathogenesis and progression.
Nur Aina Mohamad Asri +5 more
doaj +1 more source
Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide [PDF]
Journal of Stroke, 2019 Trimethylamine N-oxide (TMAO) is produced when trimethylamine, a waste product of gut microbes, is converted via hepatic flavin monooxygenases. As TMAO is a potential causative factor in various cardiovascular diseases (CVDs) considerable research ...
Hyo Suk Nam
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort
Arthritis Care &Research, EarlyView.Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo +9 more
wiley +1 more source
Structure‐Property Relationships in Catecholamine Coatings for Broad Surface Functionalization
Advanced Functional Materials, EarlyView.Inspired by mussel adhesive proteins (MAPs), six catecholamine molecules with different molecular structure were systematically characterized and compared based on their ability to form homogeneous, reactive coatings. Highlighting candidates capable of balancing coating properties of interest, their successful use as primer layers for organic and ...
Caroline F. Harms +5 more
wiley +1 more source
Toxins, 2019 Gut microbiota-dependent Trimethylamine-N-oxide (TMAO) has been reported to be strongly linked to renal function and to increased cardiovascular events in the general population and in Chronic Kidney Disease (CKD) patients.
Caroline C. Pelletier +9 more
doaj +1 more source
Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota
Microbiome, 2018 Background The dietary methylamines choline, carnitine, and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA).
Lesley Hoyles +12 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian +3 more
wiley +1 more source