Results 61 to 70 of about 16,874 (230)

TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function [PDF]

Scientific Reports, 2017
AbstractTrimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function.
Eke G. Gruppen, Erwin Garcia, Margery A. Connelly, Elias J. Jeyarajah, James D. Otvos, Stephan J. L. Bakker, Robin P. F. Dullaart   +6 more
openaire   +3 more sources

Elevation of Trimethylamine-N-Oxide in Chronic Kidney Disease: Contribution of Decreased Glomerular Filtration Rate

Toxins, 2019
Gut microbiota-dependent Trimethylamine-N-oxide (TMAO) has been reported to be strongly linked to renal function and to increased cardiovascular events in the general population and in Chronic Kidney Disease (CKD) patients.
Caroline C. Pelletier, Mikael Croyal, Lavinia Ene, Audrey Aguesse, Stephanie Billon-Crossouard, Michel Krempf, Sandrine Lemoine, Fitsum Guebre-Egziabher, Laurent Juillard, Christophe O. Soulage   +9 more
doaj   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Trimethylamine N-oxide promotes the growth of Chinese mitten crab (Eriocheir sinensis), deposition of amines, and activates the mTOR pathway by affecting metabolism of amino acids

Animal Advances
This study was conducted to evaluate the changes in amino acid metabolism and amine deposition in Chinese mitten crab (E. sinensis) fed with a diet containing Trimethylamine N-oxide (TMAO) to promote its growth and flavor. Three diets containing 0% TMAO,
Haokun Hua, Huixing Guo, Wenbin Liu, Zishang Liu, Chaofan He, Yangyang Huang, Xiufei Cao, Wei Xiong, Xi Wang, Yubo Wen, Saiwei Yin, Pengbo Wang, Aimin Wang, Guangzhen Jiang   +13 more
doaj   +1 more source

TMAO-Activated Hepatocyte-Derived Exosomes Impair Angiogenesis via Repressing CXCR4

Frontiers in Cell and Developmental Biology, 2022
Objective: Trimethylamine-N-oxide (TMAO) was found to play crucial roles in vascular endothelial function. However, the exact molecular mechanisms are not yet entirely clear. Recently, we found that exosomes (Exos) isolated from TMAO-treated hepatocytes (
Xiang Liu, Xiang Liu, Xiang Liu, Yijia Shao, Yijia Shao, Jiazichao Tu, Jiazichao Tu, Jiazichao Tu, Jiapan Sun, Bing Dong, Bing Dong, Zhichao Wang, Zhichao Wang, Jianrong Zhou, Jianrong Zhou, Jianrong Zhou, Long Chen, Jun Tao, Jun Tao, Jimei Chen, Jimei Chen, Jimei Chen   +21 more
doaj   +1 more source

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study

Scientific Reports, 2022
Elevated circulating levels of nutrient-derived trimethylamine N-oxide (TMAO) have been associated with the onset and progression of cardiovascular disease by promoting athero-thrombosis.
Anne Jomard, Luca Liberale, Petia Doytcheva, Martin F. Reiner, Daniel Müller, Michele Visentin, Marco Bueter, Thomas F. Lüscher, Roberto Vettor, Thomas A. Lutz, Giovanni G. Camici, Elena Osto   +11 more
doaj   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Microbiome-Derived Trimethylamine N-Oxide (TMAO) as a Multifaceted Biomarker in Cardiovascular Disease: Challenges and Opportunities

International Journal of Molecular Sciences
Biomarkers play a crucial role in various stages of disease management, including screening, diagnosis, prediction, prognosis, treatment, and safety monitoring.
K. Jaworska, Wojciech Kopacz, Mateusz Koper, M. Ufnal   +3 more
semanticscholar   +1 more source

PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells

Cell Death and Disease, 2022
A high plasma level of the choline-derived metabolite trimethylamine N-oxide (TMAO) is closely related to the development of cardiovascular disease. However, the underlying mechanism remains unclear.
He Liu, K. Jia, Zhengnan Ren, Jia Sun, Li-Long Pan   +4 more
semanticscholar   +1 more source