Results 51 to 60 of about 16,874 (230)

Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3

Gut microbes, 2022
Maladaptive inflammatory and immune responses are responsible for intestinal barrier integrity and function dysregulation. Proline/serine-rich coiled-coil protein 1 (PSRC1) critically contributes to the immune system, but direct data on the gut ...
Tiantian Luo, Zhigang Guo, Dan Liu, Zhongzhou Guo, Qiao Wu, Qinxian Li, Rongzhan Lin, Peier Chen, Caiwen Ou, Minsheng Chen   +9 more
semanticscholar   +1 more source

Trimethylaminuria in a 58-year-old male with liver cirrhosis and hepatitis C

European Journal of Case Reports in Internal Medicine
Trimethylaminuria (TMAU), also known as fish odor syndrome, is a rare metabolic disorder resulting from a deficiency in the enzyme flavin-containing monooxygenase 3, which is responsible for the detoxification of trimethylamine produced during the ...
Martina Knapp
doaj   +1 more source

Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease [Corrigendum]

Clinical Interventions in Aging, 2021
He W, Luo Y, Liu JP, et al. Clin Interv Aging. 2020;15:1809– 1820. The authors have advised affiliation 2 on page 1809 is incorrect, the text “Peking Union Medical College” should read “Graduate School of Peking Union ...
He W, Luo Y, Liu JP, Sun N, Guo D, Cui LL, Zheng PP, Yao SM, Yang JF, Wang H   +9 more
doaj  

Integrated Analysis Reveals the Gut Microbial Metabolite TMAO Promotes Inflammatory Hepatocellular Carcinoma by Upregulating POSTN

Frontiers in Cell and Developmental Biology, 2022
Liver cancer has a high mortality rate. Chronic inflammation is one of the leading causes of hepatocellular carcinoma. Recent studies suggested high levels of trimethylamine N-oxide (TMAO) may correlate with increased risk of inflammatory-induced liver ...
Yonglin Wu, Xing-yu Rong, Miaomiao Pan, Tongyao Wang, Han Yang, Xie Chen, Z. Xiao, Chao Zhao   +7 more
semanticscholar   +1 more source

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

Microbiome, 2018
Background The dietary methylamines choline, carnitine, and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA).
Lesley Hoyles, Maria L. Jiménez-Pranteda, Julien Chilloux, Francois Brial, Antonis Myridakis, Thomas Aranias, Christophe Magnan, Glenn R. Gibson, Jeremy D. Sanderson, Jeremy K. Nicholson, Dominique Gauguier, Anne L. McCartney, Marc-Emmanuel Dumas   +12 more
doaj   +1 more source

TMAO enhances TNF-α mediated fibrosis and release of inflammatory mediators from renal fibroblasts

Scientific Reports
Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite and TNF-α is proinflammatory cytokine, both known to be associated with renal inflammation, fibrosis and chronic kidney disease.
Kapetanaki Stefania, Kumawat Kumar Ashok, Paramel Varghese Geena, Persson Katarina, Demirel Isak   +4 more
semanticscholar   +1 more source

Trimethylamine N-Oxide (TMAO) Impairs Purinergic Induced Intracellular Calcium Increase and Nitric Oxide Release in Endothelial Cells

International Journal of Molecular Sciences, 2022
Trimethylamine N-oxide (TMAO) is a diet derived compound directly introduced through foodstuff, or endogenously synthesized from its precursors, primarily choline, L-carnitine, and ergothioneine.
G. Querio, S. Antoniotti, F. Geddo, R. Levi, M. P. Gallo   +4 more
semanticscholar   +1 more source

Serum Intestinal Metabolites are Raised in Patients with Psoriasis and Metabolic Syndrome

Clinical, Cosmetic and Investigational Dermatology, 2022
Liyun Sun,1,* Xinwei Guo,2,* Yeping Qin,3 Ping Li,4 Chunxia Yu,2 Xuesong Gao,2 Xinran Xie,4 Xuying Xu5 1Dermatology Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of ...
Sun L, Guo X, Qin Y, Li P, Yu C, Gao X, Xie X, Xu X   +7 more
doaj  

Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide [PDF]

Journal of Stroke, 2019
Trimethylamine N-oxide (TMAO) is produced when trimethylamine, a waste product of gut microbes, is converted via hepatic flavin monooxygenases. As TMAO is a potential causative factor in various cardiovascular diseases (CVDs) considerable research ...
Hyo Suk Nam
doaj   +1 more source

Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension.

Microbiology Research
The gut microbial metabolite trimethylamine N-oxide (TMAO) is regarded as a novel risk factor for hypertension. Berberine (BBR) exerts cardiovascular protective effects by regulating the gut microbiota-metabolite production pathway.
Zhichao Wang, Yijia Shao, Fang Wu, Dan Luo, Guoyifan He, Jianwen Liang, Xiaoqing Quan, Xiehui Chen, Wenhao Xia, Ye Chen, Yue Liu, Long Chen   +11 more
semanticscholar   +1 more source