Results 31 to 40 of about 16,933 (236)

Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation

Nutrition & Metabolism, 2021
Background Trimethylamine-N-oxide (TMAO) is an independent risk factor for atherosclerosis. Consumption of hawthorn fruit is believed to be cardio-protective, yet whether it is able to suppress the TMAO-induced atherosclerosis remains unexplored.
Zouyan He, Erika Kwek, Wangjun Hao, Hanyue Zhu, Jianhui Liu, Ka Ying Ma, Zhen-Yu Chen   +6 more
doaj   +1 more source

Coronary Heart Disease and TMAO Concentrations

Journal of the American College of Cardiology, 2020
We congratulate Heianza et al. ([1][1]) for their important study showing the association between a 10-year change in TMAO levels and incidence of coronary heart disease. May we kindly ask the authors to provide some additional information to help put their findings into clinical perspective?
Melissa L, Amrein, Pedro, Lopez-Ayala, Joan, Walter, Velina, Widmer, Christian, Mueller   +4 more
openaire   +2 more sources

TMAO Destabilizes RNA Secondary Structure via Direct Hydrogen Bond Interactions

, 2023
Trimethylamine N-oxide (TMAO) is an osmolyte that accumulates in cells in response to osmotic stress. TMAO stabilizes proteins by the entropic stabilization mechanism, which pictures TMAO as a nanocrowder that predominantly destabilizes the unfolded ...
Adam T. Green, D. Thirumalai (1277850), D. Thirumalai, Samuel S. Cho, Samuel S. Cho (1894093), Changbong Hyeon, Changbong Hyeon (118468), Adam T. Green (3320142)   +7 more
core   +1 more source

Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome

Molecules, 2023
TMAO is a new risk biomarker for cardiovascular disease. With trimethylammonium as its main chemical skeleton, TMAO is structurally similar to many endogenous metabolites, such as acetylcholine, carnitine, phosphorylcholine, etc. The mechanism of TMAO on
Dongyu Lei, Wenbo Yu, Yi Liu, Yujie Jiang, Xiaohui Li, Jing Lv, Ying Li   +6 more
doaj   +1 more source

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Redox Biology, 2021
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis.
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng   +19 more
doaj   +1 more source

TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

eLife, 2020
Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS).
Marta Gawrys-Kopczynska, Marek Konop, Klaudia Maksymiuk, Katarzyna Kraszewska, Ladislav Derzsi, Krzysztof Sozanski, Robert Holyst, Marta Pilz, Emilia Samborowska, Leszek Dobrowolski, Kinga Jaworska, Izabella Mogilnicka, Marcin Ufnal   +12 more
doaj   +1 more source

Circulating trimethylamine N-oxide (TMAO) in association with diet and cardiometabolic biomarkers: an international pooled analysis [PDF]

, 2020
Background: Trimethylamine N-oxide (TMAO), a diet-derived, gut microbial-host co-metabolite, has been linked to cardiometabolic diseases. However, the relationships remain unclear between diet, TMAO, and cardiometabolic health in general populations from
Yu, Danxia, Tzoulaki, Ioanna, Elliott, Paul, Yang, Jae Jeong, Karaman, I   +4 more
core   +2 more sources

The Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies

Clinical Interventions in Aging, 2021
Rui Huang,1,* Li Yan,2,* Yuhua Lei1 1Cardiovascular Disease Center, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi Prefecture, 445000, Hubei Province, People’s Republic of China ...
Huang R, Yan L, Lei Y
doaj  

Gut microbiota-dependent trimethylamine n-oxide pathway contributes to the bidirectional relationship between intestinal inflammation and periodontitis

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundIntestinal inflammation and periodontitis influence the development of each other through the bidirectional relationship. As the intestinal microbiome metabolite, trimethylamine-N-oxide (TMAO) could contribute to chronic inflammation in the gut
Qiqi Wang, Yue Sun, Yue Sun, Tianyu Zhou, Cong Jiang, Lan A, Lan A, Wenzhou Xu, Wenzhou Xu   +8 more
doaj   +1 more source

TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation

, 2022
Background. Trimethylamine-N-oxide (TMAO) has been shown to be an important player in cardiovascular disease (CVD) by promoting vascular inflammation and endothelial dysfunction.
Bingxin Huang, Jiazichao Tu, Ziqin Zhou, Jimei Chen, Jianrong Zhou, Xiang Liu   +5 more
core   +1 more source