Results 31 to 40 of about 16,874 (230)

From heart failure and kidney dysfunction to cardiorenal syndrome: TMAO may be a bridge

Frontiers in Pharmacology, 2023
The study of trimethylamine oxide (TMAO), a metabolite of gut microbiota, and heart failure and chronic kidney disease has made preliminary achievements and been summarized by many researchers, but its research in the field of cardiorenal syndrome is ...
Jialu Zhang, Peining Zhu, Siyu Li, Yufei Gao, Yue Xing   +4 more
semanticscholar   +1 more source

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Redox Biology, 2021
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis.
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng   +19 more
doaj   +1 more source

ZeXieYin Formula alleviates TMAO-induced cognitive impairment by restoring synaptic plasticity damage.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Treating cognitive impairment is a challenging and necessary research topic. ZeXieYin Formula (ZXYF), is a traditional herbal formula documented in the book of HuangDiNeiJing.
Jing Liu, Shihan Zhou, Yanqing Wang, Jinling Liu, Suping Sun, Yan Sun, Ping Xu, Xu Xu, Boran Zhu, Haoxin Wu   +9 more
semanticscholar   +1 more source

Coronary Heart Disease and TMAO Concentrations

Journal of the American College of Cardiology, 2020
We congratulate Heianza et al. ([1][1]) for their important study showing the association between a 10-year change in TMAO levels and incidence of coronary heart disease. May we kindly ask the authors to provide some additional information to help put their findings into clinical perspective?
Melissa L, Amrein, Pedro, Lopez-Ayala, Joan, Walter, Velina, Widmer, Christian, Mueller   +4 more
openaire   +2 more sources

Gut microbiota-dependent trimethylamine n-oxide pathway contributes to the bidirectional relationship between intestinal inflammation and periodontitis

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundIntestinal inflammation and periodontitis influence the development of each other through the bidirectional relationship. As the intestinal microbiome metabolite, trimethylamine-N-oxide (TMAO) could contribute to chronic inflammation in the gut
Qiqi Wang, Yue Sun, Yue Sun, Tianyu Zhou, Cong Jiang, Lan A, Lan A, Wenzhou Xu, Wenzhou Xu   +8 more
doaj   +1 more source

Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis

EBioMedicine, 2022
Summary Background Cold exposure is one of the most important risk factors for atrial fibrillation (AF), and closely related to the poor prognosis of AF patients. However, the mechanisms underlying cold-related AF are poorly understood.
Yingchun Luo, Yun Zhang, Xuejie Han, Yue Yuan, Yun Zhou, Yunlong Gao, Huihuan Yu, Jia-wei Zhang, Yiya Shi, Yu Duan, Xinbo Zhao, Sen Yan, Hongting Hao, Chenguang Dai, Shiqi Zhao, Jing Shi, Wenpeng Li, Song Zhang, Wei Xu, Ning-ning Fang, Y. Gong, Yuejiao Li   +21 more
semanticscholar   +1 more source

The Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies

Clinical Interventions in Aging, 2021
Rui Huang,1,* Li Yan,2,* Yuhua Lei1 1Cardiovascular Disease Center, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi Prefecture, 445000, Hubei Province, People’s Republic of China ...
Huang R, Yan L, Lei Y
doaj  

Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure

Frontiers in Cell and Developmental Biology, 2021
Aim: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite synthesized in host organisms from specific food constituents, such as choline, carnitine and betaine. During the last decade, elevated TMAO levels have been proposed as biomarkers
Melita Videja, Melita Videja, Reinis Vilskersts, Reinis Vilskersts, Stanislava Korzh, Helena Cirule, Eduards Sevostjanovs, Maija Dambrova, Maija Dambrova, Marina Makrecka-Kuka   +9 more
doaj   +1 more source

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Diabetes, Metabolic Syndrome and Obesity, 2023
Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
doaj  

Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

Scientific Reports, 2021
Patients with chronic kidney disease (CKD) have elevated circulating levels of trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with cardiovascular diseases.
Wenchao Zhang, Aika Miikeda, J. Zuckerman, Xun Jia, S. Charugundla, Zhiqiang Zhou, K. Kaczor‐Urbanowicz, C. Magyar, Fang Guo, Zeneng Wang, M. Pellegrini, S. Hazen, S. Nicholas, A. Lusis, D. Shih   +14 more
semanticscholar   +1 more source