Results 11 to 20 of about 12,371 (198)
Hydrophobic association and solvation of neopentane in urea, TMAO and urea–TMAO solutions [PDF]
Physical Chemistry Chemical Physics, 2021 Hydrophobic associations in pure water, urea solution, TMAO solution and urea-TMAO solution were studied using molecular dynamics simulations.
Timir Hajari +2 more
openaire +2 more sources
TMAO: a potential mediator of clopidogrel resistance [PDF]
Scientific Reports, 2021 AbstractTrimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level. However, it remains unknown whether Clopidogrel Resistance (CR) could be attributed to TMAO.
Ruisong Ma +5 more
openaire +3 more sources
Blood, 2020 In this issue of Blood, Wu and colleagues report that trimethylamine N-oxide (TMAO), an intestinal microbiome-dependent metabolite, worsens graft-versus-host disease (GVHD). They further found that TMAO induces M1 polarization of bone marrow–derived macrophages via the nucleotide-binding oligomerization domain–like receptor protein 3 (NLRP3). TMAO is
Eiko, Hayase, Robert R, Jenq
openaire +2 more sources
Entropic Stabilization of Proteins by TMAO [PDF]
The Journal of Physical Chemistry B, 2011 To understand the mechanism of trimethylamine N-oxide (TMAO) induced stabilization of folded protein states, we systematically investigated the action of TMAO on several model dipeptides (Leucine, L2, Serine, S2, Glutamine, Q2, Lysine, K2, and Glycine, G2) in order to elucidate the effect of residue-specific TMAO interactions on small fragments of ...
Cho, Samuel S. +3 more
openaire +3 more sources
TMAO-Protein Preferential Interaction Profile Determines TMAO’s Conditional In Vivo Compatibility [PDF]
Biophysical Journal, 2016 Trimethylamine N-oxide (TMAO) exemplifies how Nature uses the solute effect as a simple chemical strategy to cope with hydrodynamic pressure or urea stress to maintain proteostasis. It is a gut-microbe-generated metabolite that strongly promotes the development of atherosclerosis. It remains unclear how TMAO exerts its effects.
Jiang, Hong, Shangqin, Xiong
openaire +2 more sources
TMAO: Protecting proteins from feeling the heat [PDF]
Biophysical Journal, 2020 Osmolytes are ubiquitous in the cell and play an important role in controlling protein stability under stress. The natural osmolyte trimethylamine N-oxide (TMAO) is used by marine animals to counteract the effect of pressure denaturation at large depths.
Mayank Boob +3 more
openaire +2 more sources
Coronary Heart Disease and TMAO Concentrations
Journal of the American College of Cardiology, 2020 We congratulate Heianza et al. ([1][1]) for their important study showing the association between a 10-year change in TMAO levels and incidence of coronary heart disease. May we kindly ask the authors to provide some additional information to help put their findings into clinical perspective?
Melissa L, Amrein +4 more
openaire +2 more sources
Aerobic TMAO respiration in Escherichia coli [PDF]
Molecular Microbiology, 2007 SummaryIn the absence of oxygen, Escherichia coli can use alternative exogenous electron acceptors, including trimethylamine oxide (TMAO), to generate energy. In this study, we showed that in contrast to the other anaerobic respiratory systems, the TMAO reductase (Tor) system was expressed during both aerobiosis and anaerobiosis.
Ansaldi, Mireille +4 more
openaire +3 more sources
Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2. [PDF]
Environmental microbiology, 2014 Methylocella silvestris, an alphaproteobacterium isolated from a forest soil, can grow on trimethylamine N-oxide (TMAO) as a sole nitrogen source; however, the molecular and biochemical mechanisms underpinning its growth remain unknown. Marker-exchange mutagenesis enabled the identification of several genes involved in TMAO metabolism, including ...
Zhu, Yijun +7 more
openaire +2 more sources
Clinical Interventions in Aging, 2021 Rui Huang,1,* Li Yan,2,* Yuhua Lei1 1Cardiovascular Disease Center, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi Prefecture, 445000, Hubei Province, People’s Republic of China ...
Huang R, Yan L, Lei Y
doaj