Results 11 to 20 of about 16,933 (236)
Background Diet Influences TMAO Concentrations Associated with Red Meat Intake without Influencing Apparent Hepatic TMAO-Related Activity in a Porcine Model [PDF]
Metabolites, 2020 Red meat has been associated with an increased cardiovascular disease (CVD) risk, possibly through gut microbial-derived trimethylamine-N-oxide (TMAO).
Hanne Christine Bertram +2 more
exaly +4 more sources
Hydrophobic association and solvation of neopentane in urea, TMAO and urea–TMAO solutions [PDF]
Physical Chemistry Chemical Physics, 2021 Hydrophobic associations in pure water, urea solution, TMAO solution and urea-TMAO solution were studied using molecular dynamics simulations.
Timir Hajari +2 more
openaire +4 more sources
TMAO: Protecting proteins from feeling the heat [PDF]
Biophysical Journal, 2020 Osmolytes are ubiquitous in the cell and play an important role in controlling protein stability under stress. The natural osmolyte trimethylamine N-oxide (TMAO) is used by marine animals to counteract the effect of pressure denaturation at large depths.
Mayank Boob +3 more
openaire +5 more sources
Protein Stability in TMAO and Mixed Urea–TMAO Solutions
The Journal of Physical Chemistry B, 2020 Osmolytes are essential for cellular function under ubiquitous osmotic stress. Trimethylamine N-oxide (TMAO) is one such osmolyte that has gained remarkable attention due to its protein-protective ability against urea. This Review aims at providing a detailed account of recent theoretical and experimental developments in characterizing the structural ...
Pritam Ganguly +4 more
core +5 more sources
Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2. [PDF]
Environmental microbiology, 2014 Methylocella silvestris, an alphaproteobacterium isolated from a forest soil, can grow on trimethylamine N-oxide (TMAO) as a sole nitrogen source; however, the molecular and biochemical mechanisms underpinning its growth remain unknown. Marker-exchange mutagenesis enabled the identification of several genes involved in TMAO metabolism, including ...
Zhu, Yijun +7 more
openaire +4 more sources
Trimethylamine-N-oxide (TMAO) increased aquaporin-2 expression in spontaneously hypertensive rats
Clinical and Experimental Hypertension, 2019 Recent evidence suggests that elevated plasma levels of Trimethylamine-N-oxide (TMAO) can prolong the duration of elevated blood pressure in rats. The purpose of this study was to investigate the plasma TMAO level in Spontaneously Hypertensive Rats (SHR)
Min Liu, Qinghua Han, Jinglu Yang
doaj +2 more sources
Trimethylamine N-Oxide (TMAO) as a Biomarker
, 2022 The interaction between diet, microbiome, and noncommunicable disease onset is gaining growing attention. The trimethylamine N-oxide (TMAO) is a gut microbiota derivative that has been suggested as a potential regulator of human health, especially (but not exclusively) for its association with cardiovascular diseases. It derives from the trimethylamine
Rosita Gabbianelli, Laura Bordoni
core +4 more sources
Effect of urea and tmao on lipid bilayers [PDF]
European Pharmaceutical Journal, 2017 Abstract We study the effect of the osmolytes, Urea and trimethylamine-N-oxide (TMAO) on POPE (1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine) lipid membranes using SAXS/WAXS and DSC. Their antagonist effect is observed with TMAO stabilizing and Urea destabilizing the lipid bilayer, as seen by others in earlier researches.
J. Valerio, S.S. Funari, S. Bernstorff
openaire +4 more sources
Lipids in Health and Disease, 2022 Background Trimethylamine N-oxide (TMAO)-related metabolites are associated with the pathogenesis of atherosclerotic cardiovascular disease (ASCVD) and are known to disrupt lipid metabolism.
Xiaowei Xiong +6 more
doaj +2 more sources
Lifelong TMAO exposure exerts hypotensive effects in aged spontaneously hypertensive rats [PDF]
Frontiers in Cardiovascular MedicineTrimethylamine N-oxide (TMAO), a bacterial metabolite associated with cardiovascular risk, has a debated role, with evidence suggesting both harmful and protective effects.
Wojciech Kopacz +3 more
doaj +2 more sources