Results 21 to 30 of about 16,874 (230)
TMAO: Protecting proteins from feeling the heat [PDF]
Biophysical Journal, 2020 Osmolytes are ubiquitous in the cell and play an important role in controlling protein stability under stress. The natural osmolyte trimethylamine N-oxide (TMAO) is used by marine animals to counteract the effect of pressure denaturation at large depths.
Mayank Boob +3 more
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Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases
Biomedicines, 2023 Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in humans. There are factors that affect one’s TMAO level, such as diet, drugs, age,
semanticscholar +1 more source
Nutrition & Metabolism, 2021 Background Trimethylamine-N-oxide (TMAO) is an independent risk factor for atherosclerosis. Consumption of hawthorn fruit is believed to be cardio-protective, yet whether it is able to suppress the TMAO-induced atherosclerosis remains unexplored.
Zouyan He +6 more
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Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite
International Journal of Molecular Sciences, 2023 Endothelial function is essential in the maintenance of systemic homeostasis, whose modulation strictly depends on the proper activity of tissue-specific angiocrine factors on the physiopathological mechanisms acting at both single and multi-organ levels.
G. Querio +4 more
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TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats
eLife, 2020 Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS).
Marta Gawrys-Kopczynska +12 more
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Entropic Stabilization of Proteins by TMAO [PDF]
The Journal of Physical Chemistry B, 2011 To understand the mechanism of trimethylamine N-oxide (TMAO) induced stabilization of folded protein states, we systematically investigated the action of TMAO on several model dipeptides (Leucine, L2, Serine, S2, Glutamine, Q2, Lysine, K2, and Glycine, G2) in order to elucidate the effect of residue-specific TMAO interactions on small fragments of ...
Cho, Samuel S. +3 more
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Open Chemistry, 2023 The intestinal microbial metabolite trimethylamine oxide (TMAO) affects the formation and development of atherosclerosis (AS). The design and development of an effective targeted drug to reduce serum TMAO levels may provide new avenues for inhibiting AS ...
Luo Jiaxin +3 more
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Frontiers in Endocrinology, 2023 Introduction Childhood obesity leads to early subclinical atherosclerosis and arterial stiffness. Studying biomarkers like trimethylamine N-oxide (TMAO), linked to cardio-metabolic disorders in adults, is crucial to prevent long-term cardiovascular ...
Monica-Simina Mihuta +7 more
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Aerobic TMAO respiration in Escherichia coli [PDF]
Molecular Microbiology, 2007 SummaryIn the absence of oxygen, Escherichia coli can use alternative exogenous electron acceptors, including trimethylamine oxide (TMAO), to generate energy. In this study, we showed that in contrast to the other anaerobic respiratory systems, the TMAO reductase (Tor) system was expressed during both aerobiosis and anaerobiosis.
Ansaldi, Mireille +4 more
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Molecules, 2023 TMAO is a new risk biomarker for cardiovascular disease. With trimethylammonium as its main chemical skeleton, TMAO is structurally similar to many endogenous metabolites, such as acetylcholine, carnitine, phosphorylcholine, etc. The mechanism of TMAO on
Dongyu Lei +6 more
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