Results 21 to 30 of about 16,933 (236)
Lactobacilli and Bifidobacterium as anti- atherosclerotic agents [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Atherosclerosis is the thickening or hardening of the arteries which is caused by a buildup of atheromatous plaque in the inner lining of an artery. Hypercholesterolemia, inflammation, oxidative stress, and trimethylamine N-oxide (TMAO) are important ...
Milad Abdi +2 more
doaj +1 more source
Effects of SGLT-2 Inhibitors on Plasma Concentrations and Renal Clearance of the Risk Marker Trimethylamine-N-Oxide in Patients With Type-2 Diabetes. [PDF]
Endocrinol Diabetes MetabTreatment with empagliflozin or dapagliflozin was associated with a modest increase in plasma concentration of TMAO in Type 2 diabetes patients. These findings suggest a possible class effect of SGLT‐2 inhibitors. Whether this effect impacts the overall clinical benefits of SGLT‐2 inhibitors needs to be subject to further investigation.
Zimmer KB +6 more
europepmc +2 more sources
Blood, 2020 In this issue of Blood, Wu and colleagues report that trimethylamine N-oxide (TMAO), an intestinal microbiome-dependent metabolite, worsens graft-versus-host disease (GVHD). They further found that TMAO induces M1 polarization of bone marrow–derived macrophages via the nucleotide-binding oligomerization domain–like receptor protein 3 (NLRP3). TMAO is
Eiko, Hayase, Robert R, Jenq
openaire +2 more sources
TMAO: a potential mediator of clopidogrel resistance [PDF]
Scientific Reports, 2021 AbstractTrimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level. However, it remains unknown whether Clopidogrel Resistance (CR) could be attributed to TMAO.
Ruisong Ma +5 more
openaire +3 more sources
Entropic Stabilization of Proteins by TMAO [PDF]
The Journal of Physical Chemistry B, 2011 To understand the mechanism of trimethylamine N-oxide (TMAO) induced stabilization of folded protein states, we systematically investigated the action of TMAO on several model dipeptides (Leucine, L2, Serine, S2, Glutamine, Q2, Lysine, K2, and Glycine, G2) in order to elucidate the effect of residue-specific TMAO interactions on small fragments of ...
Cho, Samuel S. +3 more
openaire +3 more sources
TMAO-Protein Preferential Interaction Profile Determines TMAO’s Conditional In Vivo Compatibility [PDF]
Biophysical Journal, 2016 Trimethylamine N-oxide (TMAO) exemplifies how Nature uses the solute effect as a simple chemical strategy to cope with hydrodynamic pressure or urea stress to maintain proteostasis. It is a gut-microbe-generated metabolite that strongly promotes the development of atherosclerosis. It remains unclear how TMAO exerts its effects.
Jiang, Hong, Shangqin, Xiong
openaire +2 more sources
EXCLI Journal : Experimental and Clinical Sciences, 2022 Trimethylamine N-oxide (TMAO) is a biomarker of cardiovascular risk and may enhance the progression of atherosclerosis. The aim of the study was to determine whether there are sex-specific differences in TMAO concentrations before and after cardiac ...
Andreas Baranyi +13 more
doaj +1 more source
Open Chemistry, 2023 The intestinal microbial metabolite trimethylamine oxide (TMAO) affects the formation and development of atherosclerosis (AS). The design and development of an effective targeted drug to reduce serum TMAO levels may provide new avenues for inhibiting AS ...
Luo Jiaxin +3 more
doaj +1 more source
Aerobic TMAO respiration in Escherichia coli [PDF]
Molecular Microbiology, 2007 SummaryIn the absence of oxygen, Escherichia coli can use alternative exogenous electron acceptors, including trimethylamine oxide (TMAO), to generate energy. In this study, we showed that in contrast to the other anaerobic respiratory systems, the TMAO reductase (Tor) system was expressed during both aerobiosis and anaerobiosis.
Ansaldi, Mireille +4 more
openaire +3 more sources
JCI Insight, 2023 We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes inflammation via trained immunity (TI).
Fatma Saaoud +18 more
doaj +1 more source