Results 71 to 80 of about 553,444 (284)

Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia

Gut microbes
Pre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens the health and safety of the mother and child. Studies have shown that an imbalance in gut microbiota can affect the progression of PE.
Jiayi Wang, Yajie Gao, Shuaijun Ren, Jialin Li, Siqian Chen, Jiating Feng, Bing He, Yuping Zhou, Rongrong Xuan   +8 more
semanticscholar   +1 more source

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

Nutrients, 2018
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several factors including diet, gut microbial flora, drug administration and liver flavin ...
M. H. Janeiro, M. J. Ramírez, F. Milagro, J. Martínez, M. Solas   +4 more
semanticscholar   +1 more source

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

HYPERTENSION, 2020
Supplemental Digital Content is available in the text. Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases.
Vienna E. Brunt, R. Gioscia-Ryan, Abigail G. Casso, Nicholas S. VanDongen, B. Ziemba, Zachary J. Sapinsley, James J. Richey, Melanie C. Zigler, A. Neilson, K. Davy, D. Seals   +10 more
semanticscholar   +1 more source

Gut‒heart axis: emerging therapies targeting trimethylamine N-oxide production

Gut Microbes
Trimethylamine N-oxide (TMAO) has garnered considerable attention because of its role in the pathophysiology and pathogenesis of various disorders, particularly heart and kidney disease.
Efrain Ricardo Torres, Jennifer Wilcox, W. H. Wilson Tang   +2 more
doaj   +1 more source

Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction

Cellular Physiology and Biochemistry, 2017
Background/Aim: Plasma trimethylamine-N-oxide (TMAO), a product of intestinal microbial metabolism of dietary phosphatidylcholine has been recently associated with atherosclerosis and increased risk of cardiovascular diseases (CVD) in rodents and humans.
Krishna M. Boini, Tahir Hussain, Pin-Lan Li, Sai S Koka   +3 more
doaj   +1 more source

The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. [PDF]

PLoS ONE, 2016
UNLABELLED:The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.
Ruben Poesen, Pieter Evenepoel, Henriette de Loor, Jan A Delcour, Christophe M Courtin, Dirk Kuypers, Patrick Augustijns, Kristin Verbeke, Björn Meijers   +8 more
doaj   +1 more source

Synthesis of cyclopropanes via organoiron methodology: stereoselective preparation of cis-2-(2’-carboxycyclopropyl)glycine [PDF]

, 2002
A stereoselective route to cis-2-(2′-carboxycyclopropyl)glycine has been developed. exo-Nucleophilic addition to the (bicyclo[5.1.0]octadienyl)iron(1+) cation establishes the relative stereochemistry at the cyclopropane ring and the α-stereocenter ...
Donaldson, William, Wallock, Nathaniel J
core   +2 more sources

Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition.

Kidney International
Intestinal microbiota and their metabolites affect systemic inflammation and kidney disease outcomes. Here, we investigated the key metabolites associated with the acute kidney injury (AKI)-to chronic kidney disease (CKD) transition and the effect of ...
Jeonghwan Lee, Jinhaeng Lee, Kyu-Hyeon Kim, Jiwon Lee, Youngae Jung, J. Hyeon, Areum Seo, Wencheng Jin, Boram Weon, Nayeon Shin, Sejoong Kim, Chun Soo Lim, Y. S. Kim, J. P. Lee, Geum-Sook Hwang, S. Yang   +15 more
semanticscholar   +1 more source

A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-MEAT).

American Journal of Clinical Nutrition, 2020
BACKGROUND Despite the rising popularity of plant-based alternative meats, there is limited evidence of the health effects of these products. OBJECTIVES We aimed to compare the effect of consuming plant-based alternative meat (Plant) as opposed to ...
Anthony Crimarco, Sparkle Springfield, Christina I. Petlura, Taylor Streaty, K. Cunanan, Justin Lee, Priya Fielding‐Singh, M. M. Carter, Madeline A. Topf, H. Wastyk, E. Sonnenburg, J. Sonnenburg, C. Gardner   +12 more
semanticscholar   +1 more source

Pressing the trimethylamine N-oxide narrative

AME Medical Journal, 2017
We read with interest the correspondence titled “Gut Microbe-Generated Trimethylamine N-Oxide from Dietary Choline is Prothrombotic in Subjects”, published by Zhu et al . in the journal Circulation (1). This work builds on an emerging body of evidence which has suggested a role for the gut-derived metabolite, trimethylamine N -oxide (TMAO), in the ...
Kevin C. Klatt, Marie A. Caudill
openaire   +1 more source