Results 81 to 90 of about 553,444 (284)

Association of diet with circulating trimethylamine-N-oxide concentration [PDF]

The American Journal of Clinical Nutrition, 2020
Trimethylamine-N-oxide (TMAO) is a compound that is present in seafood and produced through human gut microbial metabolism of its precursors. Previous studies have suggested that elevated TMAO concentrations are associated with an increased risk of cardiovascular events. However, the association between diet and TMAO concentrations in free-living adult
Rikuta Hamaya, Kerry L Ivey, Dong H Lee, Molin Wang, Jun Li, Adrian Franke, Qi Sun, Eric B Rimm   +7 more
openaire   +2 more sources

Flexible Chemiresistive Chitosan‐Glycerol Sensors on Laser‐Induced Graphene Electrodes for Room‐Temperature Ammonia Detection

Advanced Materials Technologies, EarlyView.
Flexible Chitosan‐glycerol sensor integrated with porous laser‐induced graphene (LIG) electrodes enable room‐temperature chemiresistive detection of ammonia (NH3) and proof‐of‐concept detection of fish spoilage. ABSTRACT We report a metal‐free sensor platform combining laser induced graphene (LIG) electrodes with drop‐deposited, glycerol‐plasticized ...
Mintesinot Tamiru Mengistu, Richard Murray, Cara‐Lena Nies, Cathal Larrigy, Martina Piletti, Jahidul Islam, Daniela Iacopino, Eileen Hurley, Michael Nolan, Aidan J. Quinn   +9 more
wiley   +1 more source

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Diabetes, Metabolic Syndrome and Obesity, 2023
Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
doaj  

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

Frontiers in Cardiovascular Medicine, 2021
Atherosclerosis is associated with various pathological manifestations, such as ischemic heart disease, ischemic stroke, and peripheral arterial disease, and remains a leading cause of public health concern.
BingYu Wang, Jun Qiu, JiangFang Lian, JiangFang Lian, Xi Yang, JianQing Zhou, JianQing Zhou   +6 more
doaj   +1 more source

Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding [PDF]

, 2010
Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. These diseases can be hereditary in humans and four of the many disease-associated missense mutants of PrP are in the ...
Daggett, Valerie, van der Kamp, Marc W
core   +2 more sources

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women

European Heart Journal, 2018
AIMS Carnitine and choline are major nutrient precursors for gut microbiota-dependent generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO).
Zeneng Wang, N. Bergeron, B. Levison, Xinmin S Li, S. Chiu, Xun Jia, Robert A. Koeth, Lin Li, Yuping Wu, W. Tang, R. Krauss, S. Hazen   +11 more
semanticscholar   +1 more source

The roles of trimethylamine-N-oxide in atherosclerosis and its potential therapeutic aspect: A literature review

Biomolecules & biomedicine, 2023
Current research supports the evidence that the gut microbiome (GM), which consists of gut microbiota and their biologically active metabolites, is associated with atherosclerosis development.
Y. Oktaviono, Ariikah Dyah Lamara, P. B. T. Saputra, J. Arnindita, D. Pasahari, M. E. Saputra, Ni Made Adnya Suasti   +6 more
semanticscholar   +1 more source

Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients [PDF]

Journal of the American Society of Nephrology, 2016
Cardiovascular disease causes over 50% of the deaths in dialysis patients, and the risk of death is higher in white than in black patients. The underlying mechanisms for these findings are unknown. We determined the association of the proatherogenic metabolite trimethylamine N-oxide (TMAO) with cardiovascular outcomes in hemodialysis patients and ...
Tariq, Shafi, Neil R, Powe, Timothy W, Meyer, Seungyoung, Hwang, Xin, Hai, Michal L, Melamed, Tanushree, Banerjee, Josef, Coresh, Thomas H, Hostetter   +8 more
openaire   +2 more sources

Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide [PDF]

APMIS, 2020
The increasing prevalence of cardiovascular diseases cannot adequately be explained by traditional risk factors. Recently, accumulating evidence has suggested that gut microbiota‐derived numerous metabolites are contributors to atherosclerotic events.
Zhu, Yingqian, Li, Qingqing, Jiang, Hua
openaire   +2 more sources

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source