Results 91 to 100 of about 17,902 (222)

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Monooxygenase-dehydrogenase cascade for sustained enzymatic remediation of TMA in salmon protein hydrolysates

Applied and Environmental Microbiology
Fish protein hydrolysates hold great promise as nutraceuticals, yet their application as food ingredients or nutraceuticals is currently limited by their fish-like odor. This odor is mainly due to the presence of trimethylamine (TMA), a volatile biogenic
Rasmus Ree, Øivind Larsen, Sushil Gaykawad, Sreerekha S. Ramanand, Antonio García-Moyano, Irina Elena Chiriac, Pål Puntervoll, Gro Elin Kjæreng Bjerga   +7 more
doaj   +1 more source

Trimethylamine N -Oxide

Recent evidence, including massive gene-expression analysis and a wide-variety of other multi-omics approaches, demonstrates an interplay between gut microbiota and the regulation of plasma lipids. Gut microbial metabolism of choline and -carnitine results in the formation of trimethylamine (TMA) and concomitant conversion into trimethylamine- N -oxide
Canyelles, Marina||, Tondo, Mireia||, Cedó, Lídia||, Farràs Mañé, Marta||, Escolà-Gil, Joan Carles||, Blanco Vaca, Francisco||   +5 more
openaire   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism

mBio
Anaerobic metabolism of dietary choline to trimethylamine (TMA) by the human gut microbiome is a disease-associated pathway. The host’s impaired ability to oxidize TMA to trimethylamine-N-oxide (TMAO) results in trimethylaminuria (TMAU), while elevated ...
Amelia Y. M. Woo, Walter J. Sandoval-Espinola, Maud Bollenbach, Alison Wong, Mariko Sakanaka-Yokoyama, Qijun Zhang, Vincent Nieto, Federico E. Rey, Emily P. Balskus   +8 more
doaj   +1 more source

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions

Small, EarlyView.
Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom, Jae Hun Ahn, Jung Yung Kim, Kyo Chul Lee, Yong Jin Lee, Sanoj Rejinold N, Jin‐Ho Choy   +6 more
wiley   +1 more source

High‐Efficiency Lithium Sulfur Cells With Suppressed Polysulfide Solubility Using a Cost‐Effective Ammonium‐Based Ionic Liquid Electrolyte

Small, EarlyView.
The cost‐effective ammonium‐based ionic liquid electrolyte, N₁₁₁3FSI, suppresses polysulfide dissolution to sub‐millimolar levels in lithium–sulfur batteries. The electrolyte promotes efficient FSI− anion reduction, forming a dense, LiF‐rich solid‐electrolyte interphase on both the lithium metal anode and sulfur cathode. This dual‐electrode passivation
Ajit Kumar, Frederick Nti, Pratima Kumari, Mahin Maleki, Steve Rowlands, Paul M. Bayley, Robert Kerr, Anthony Somers, Maria Forsyth, Patrick C. Howlett   +9 more
wiley   +1 more source

Plasma‐Enabled Simultaneous Synthesis and Nano‐Anchoring of TiO2−x Nanolayers on Mesoporous Bio‐Silica for Effective Photodegradation of Tetramethylammonium Hydroxide

SusMat, EarlyView.
A defect‐rich TiO2−x nanolayer was simultaneously synthesized and nano‐anchored on a mesoporous bio‐silica (diatomite) through a rapid, low‐temperature atmospheric‐pressure plasma process in aqueous media. The optimized TiO2−x/bio‐silica composite (DE 700) exhibits oxygen vacancies, an anatase–rutile heterointerface, broad solar‐spectrum absorption ...
Ali M. Abou‐Elanwar, Sunwoo Kim, So Young Lee, Jeongkyun Yu, Donguk Choi, Min Seob Kim, Chihyun Hwang, Hyungmin Park, Youngtai Noh, Nam Dong Kim, Ming Xie, Jiuyang Lin, Seongju Park, Youngjin Kim, Dong Han Seo   +14 more
wiley   +1 more source

Preparation of Hydrophilic Polysilsesquioxanes and Their Applications as Water Separation and Antifogging Coating Materials

The Chemical Record, EarlyView.
Hydrophilic substituents were introduced onto the silicon atoms of random polysilsesquioxanes (PSQs) to improve water permeability and absorptivity for exploring the applications of PSQ materials as heat‐ and chlorine‐resistant water desalination reverse osmosis (RO) membranes and scratch‐resistant antifogging coating materials.
Takashi Hamada, Yohei Adachi, Joji Ohshita   +2 more
wiley   +1 more source