Results 61 to 70 of about 19,127 (154)

Divergence between circulating trimethylamine and trimethylamine-N-oxide associated with common flavin-containing monooxygenase 3 variation

iScience
Summary: Flavin-containing monooxygenase 3 (FMO3) oxidizes trimethylamine (TMA), a gut-derived metabolite of dietary substrates such as choline and betaine, into trimethylamine-N-oxide (TMAO), which has been linked to cardiometabolic and renal diseases ...
Justin Tang, Joshua A. Zaretsky, Jaden D. Labajo, Abir Shaqo, Hamza Dakroub, Gia V. Shelp, Elizabeth M. Poole, Sarah E. Burns, Clara E. Cho   +8 more
doaj   +1 more source

Trimethylamine N -Oxide

Recent evidence, including massive gene-expression analysis and a wide-variety of other multi-omics approaches, demonstrates an interplay between gut microbiota and the regulation of plasma lipids. Gut microbial metabolism of choline and -carnitine results in the formation of trimethylamine (TMA) and concomitant conversion into trimethylamine- N -oxide
Canyelles, Marina||, Tondo, Mireia||, Cedó, Lídia||, Farràs Mañé, Marta||, Escolà-Gil, Joan Carles||, Blanco Vaca, Francisco||   +5 more
openaire   +1 more source

Monooxygenase-dehydrogenase cascade for sustained enzymatic remediation of TMA in salmon protein hydrolysates

Applied and Environmental Microbiology
Fish protein hydrolysates hold great promise as nutraceuticals, yet their application as food ingredients or nutraceuticals is currently limited by their fish-like odor. This odor is mainly due to the presence of trimethylamine (TMA), a volatile biogenic
Rasmus Ree, Øivind Larsen, Sushil Gaykawad, Sreerekha S. Ramanand, Antonio García-Moyano, Irina Elena Chiriac, Pål Puntervoll, Gro Elin Kjæreng Bjerga   +7 more
doaj   +1 more source

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism

mBio
Anaerobic metabolism of dietary choline to trimethylamine (TMA) by the human gut microbiome is a disease-associated pathway. The host’s impaired ability to oxidize TMA to trimethylamine-N-oxide (TMAO) results in trimethylaminuria (TMAU), while elevated ...
Amelia Y. M. Woo, Walter J. Sandoval-Espinola, Maud Bollenbach, Alison Wong, Mariko Sakanaka-Yokoyama, Qijun Zhang, Vincent Nieto, Federico E. Rey, Emily P. Balskus   +8 more
doaj   +1 more source

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia

Alzheimer's Research & Therapy
AbstractBackgroundThe gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnitine – have been associated with an increased risk of cardiovascular disease, but their relation to cognition, neuroimaging markers, and dementia remains uncertain.MethodsIn the population-based Rotterdam Study, we ...
Yaqub, A, Vojinovic, D, Vernooij, MW, Slagboom, PE, Ghanbari, M, Beekman, M, van der Grond, J, Hankemeier, T, van Duijn, CM, Ikram, MA, Ahmad, S   +10 more
openaire   +5 more sources

Trimethylamine N-oxide Reductase

NIPPON SUISAN GAKKAISHI, 1975
Morihiko SAKAGUCHI, Akira KAWAI
openaire   +2 more sources

Trimethylamine N-Oxide (TMAO) and Atherosclerosis

This monograph provides a concise overview of the emerging role of trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, in the pathogenesis of atherosclerosis. It reviews the molecular mechanisms linking TMAO with endothelial dysfunction, vascular inflammation, and atherogenesis, together with current and emerging TMAO-targeted ...
openaire   +2 more sources

Trimethylamine N-Oxide in Seafood

Journal of the American College of Cardiology, 2016
Jørgen Valeur, Bjarne Landfald, Arnold Berstad, Jan Raa   +3 more
openaire   +1 more source

Gut microbiota-derived trimethylamine N-oxide (TMAO) and its association with neuroinflammation in migraine. [PDF]

Indian J Med Res
Atıcı Y, Eruyar E, Ökten Z, Serdar CC, Serdar MA, Yücel D.   +5 more
europepmc   +1 more source

The Gut-Heart-Kidney Axis in Heart Failure: Trimethylamine N-Oxide and Beyond-A State-of-the-Art Review. [PDF]

Biomedicines
Yusuf IA, Anighoro S, Sultany A, Nawaz S, Adhikari A, Bajpai S, Ullah A, Sharma A, Grover S, Gopireddy NSR, Gondal A, Bernshteyn M, Ghimire S.   +12 more
europepmc   +1 more source