Results 61 to 70 of about 17,902 (222)

Trimethylamine-N-oxide is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis

Renal Failure, 2020
Background Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary l-carnitine and choline, cleared by the kidney, has been implicated in the ...
Yin Zheng, Zihui Tang, Li You, Yuanhao Wu, Junfeng Liu, Jun Xue   +5 more
doaj   +1 more source

Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxide. [PDF]

PLoS ONE, 2017
Without a glucocorticoid (GC) ligand, the transcription factor glucocorticoid receptor (GR) is largely cytoplasmic, with its GC-binding domain held in high affinity conformation by a cluster of chaperones.
Aaron L Miller, W Austin Elam, Betty H Johnson, Shagufta H Khan, Raj Kumar, E Brad Thompson   +5 more
doaj   +1 more source

Recent Advance for PVDF Based Flexible Piezoelectric Sensors

EcoEnergy, EarlyView.
This review focus on the structural regulation of PVDF via boundary confinement, blending regulation, electric‐field‐assisted orientation, and chemical modification for flexible piezoelectric sensors. ABSTRACT The rapid advancement of flexible electronics, wearable devices, and biomedical engineering has spurred increasing demand for sensor materials ...
Chaoran Tan, Aokai Yang, Yuyang Ling, Meilin Liu, Liang Huang   +4 more
wiley   +1 more source

Trimethylamine N-Oxide as a Novel Therapeutic Target in CKD [PDF]

Journal of the American Society of Nephrology, 2016
Patients with CKD are at an increased risk for the development of cardiovascular disease even beyond traditional risk factors. Although uremic toxins have been proposed as important contributors in the pathogenesis of cardiovascular and renal disease progression in CKD, the sources and the ...
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Trimethylamine N-Oxide Promotes Cell Proliferation and Angiogenesis in Colorectal Cancer

Journal of Immunology Research, 2022
Background. Of all intestinal microbiome-derived metabolites, trimethylamine N-oxide (TMAO) has received increasing attention because of its potent role in colorectal cancer development.
Shuyan Yang, Hui Dai, Yimei Lu, Rui Li, Chengjin Gao, Shuming Pan   +5 more
doaj   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Arterial Perivascular Space‐Mediated Solute Transport in the Mouse Brain

Exploration, EarlyView.
The mechanisms underlying solute clearance from the brain parenchyma remain debated, with competing hypotheses involving bulk cerebrospinal fluid flow versus perivascular transport. Using multimodal in vivo imaging and computational modeling in mice, this study demonstrates that arterial pulsation drives bidirectional solute movement within the ...
Shiyong Li, Ye Wang, Guangyu Jia, Yamei Yu, Zhe Zhang, Qi Wang, Kaelyn V. Becker, Jonathan W. Engle, Dawei Jiang, Weibo Cai   +9 more
wiley   +1 more source

The food-derived metabolite trimethylamine and trimethylamine-N-oxide promote colorectal cancer progression via SREBF1

Ecotoxicology and Environmental Safety
Colorectal cancer (CRC) is characterised by microbial dysbiosis. Trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) are gut microbiota-derived metabolites produced from dietary precursors that are implicated in CRC progression.
Yang Yan, Jiaxuan Li, Hejia Xu, Chen Yang, Guifang Li, Yanyan Feng, Qian Wang, Li Li, Rendi Wu, Hairong Sun, Ting Zhang, Fang Wang, Yong Mao   +12 more
doaj   +1 more source

Body‐integrated photonic biosensors: Illuminating the path to active healthcare

FlexMat, EarlyView.
Body‐integrated photonic biosensors are promising tools for active healthcare. These optical devices can be worn, implanted, or swallowed to monitor health signals continuously. This review introduces key sensing modalities, including fluorescence, colorimetry, SPR, LSPR, SERS, and light‐modulating materials.
Jiayue Gu, Xingming Wen, Qihang Yan, Yining Zhao, Linghao Yuan, Siyuan Chen, Yue Ma, Zhengyue Fang, Dong Lei, Yuxin Liu, Ze Xiong   +10 more
wiley   +1 more source