Results 31 to 40 of about 553,444 (284)

Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics

Pharmaceuticals, 2023
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely associated with diseases such as atherosclerosis and hypertension, and ...
Meyammai Shanmugham, S. Bellanger, C. H. Leo   +2 more
semanticscholar   +1 more source

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V, Sharpton, Suzanne R, Terrault, Norah A, Yong, Germaine JM   +3 more
core   +1 more source

The biosynthesis of trimethylamine-N-oxide

Biochimica et Biophysica Acta, 1960
Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in
J, BAKER, S, CHAYKIN
openaire   +3 more sources

Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet [PDF]

, 2017
Gut microbiota is emerging as a novel risk factor for atherothrombosis, but the predictive role of gut-derived lipopolysaccharide (LPS) is unknown. We analyzed (1) the association between LPS and major adverse cardiovascular events (MACE) in atrial ...
Cammisotto, Vittoria, Carnevale, Roberto, Menichelli, Danilo, Nocella, Cristina, Novo, Marta, Pastori, Daniele, Pignatelli, Pasquale, Santulli, Maria, Violi, Francesco   +8 more
core   +1 more source

Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health [PDF]

, 2018
Purpose of this Review: This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.
Chambers, Edward S., Frost, Gary, Morrison, Douglas J., Preston, Tom   +3 more
core   +1 more source

Microbiome, trimethylamine N-oxide, and cardiometabolic disease [PDF]

Translational Research, 2017
There is increasing appreciation that changes in microbiome composition and function can promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites that are biologically active, such as trimethylamine N-oxide (TMAO), are now recognized as contributors to atherogenesis.
W.H. Wilson Tang, Stanley L. Hazen
openaire   +2 more sources

Computational Study of Selected Amine and Lactam N-Oxides Including Comparisons of N-O Bond Dissociation Enthalpies with Those of Pyridine N-Oxides

Molecules, 2020
A computational study of the structures and energetics of amine N-oxides, including pyridine N-oxides, trimethylamine N-oxide, bridgehead bicyclic amine N-oxides, and lactam N-oxides, allowed comparisons with published experimental data.
Arthur Greenberg, Alexa R. Green, Joel F. Liebman   +2 more
doaj   +1 more source

Escherichia coli TatA and TatB Proteins Have N-out, C-in Topology in Intact Cells [PDF]

, 2012
The twin arginine protein transport (Tat) system translocates folded proteins across the cytoplasmic membrane of prokaryotes and the thylakoid membrane of chloroplasts.
Alami, Bartolomé, Bauer, Berks, Bernhardt, Berthelmann, Bogsch, Bolhuis, Bryson, Buchanan, Casadaban, Chan, Cline, Cline, Dabney-Smith, Dabney-Smith, de Leeuw, De Leeuw, Gohlke, Gouffi, Greene, Hashimoto-Gotoh, Heijne, Hu, Ize, Jack, Jack, Laemmli, Leake, Lee, Leive, Lu, Maegawa, Maldonado, Mori, Mori, Palmer, Palmer, Porcelli, Punginelli, Richter, Sambrook, Sargent, Sargent, Sargent, Sauvé, Silvestro, Simons, Stanley, Stevenson, Tarry, Tarry, Towbin, Walther, Wang, Weiner, Wessel, Wexler, Yen   +58 more
core   +3 more sources

Untargeted lipidomic features associated with colorectal cancer in a prospective cohort. [PDF]

, 2018
BackgroundEpidemiologists are beginning to employ metabolomics and lipidomics with archived blood from incident cases and controls to discover causes of cancer.
Cai, Xiaoming, Dudoit, Sandrine, Edmands, William MB, Grigoryan, Hasmik, Gunter, Marc J, Naccarati, Alessio, Perttula, Kelsi, Petrick, Lauren, Polidoro, Silvia, Rappaport, Stephen M, Schiffman, Courtney, Vineis, Paolo   +11 more
core   +3 more sources

High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

Science, 2021
Gut bugs and systemic disease risk What people eat has an immediate selective effect on the microbial populations resident in the gut. A high-fat diet is associated with the occurrence of microbes that catabolize choline and the accumulation of ...
Woongjae Yoo, Jacob K. Zieba, N. J. Foegeding, Teresa P. Torres, Catherine D. Shelton, Nicolas G. Shealy, Austin J Byndloss, Stephanie A. Cevallos, E. Gertz, Connor R. Tiffany, Julia D. Thomas, Yael Litvak, Henry Nguyen, Erin E. Olsan, Brian J. Bennett, J. Rathmell, A. Major, A. Bäumler, M. Byndloss   +18 more
semanticscholar   +1 more source