The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases
Frontiers in Endocrinology, 2023 Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide. Researchers have found that the occurrence and development of CVDs are closely related to intestinal microecology.
Jing Zhen +13 more
doaj +1 more source
Quantification of Trimethylamine-N-Oxide and Trimethylamine in Fish Oils for Human Consumption
MoleculesSupplementing fish oil is one of the strategies to reduce the risk of cardiovascular disease, the leading cause of death around the world. Contradictorily, fish oil may also contain trimethylamine-N-oxide, a recently emerged risk factor for ...
Dominik Dörfel +2 more
doaj +1 more source
Association of diet with circulating trimethylamine-N-oxide concentration [PDF]
The American Journal of Clinical Nutrition, 2020 Trimethylamine-N-oxide (TMAO) is a compound that is present in seafood and produced through human gut microbial metabolism of its precursors. Previous studies have suggested that elevated TMAO concentrations are associated with an increased risk of cardiovascular events. However, the association between diet and TMAO concentrations in free-living adult
Rikuta Hamaya +7 more
openaire +2 more sources
Intestinal Microbiota Metabolism and Atherosclerosis
Chinese Medical Journal, 2015 Objective: This review aimed to summarize the relationship between intestinal microbiota metabolism and cardiovascular disease (CVD) and to propose a novel CVD therapeutic target.
Tian-Xing Liu +2 more
doaj +1 more source
TMAO metaorganismal pathway and chronic inflammatory diseases [PDF]
Exploration of MedicineNutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA.
Zeneng Wang, Shumei Man, Robert Koeth
doaj +1 more source
Effects of Choline Metabolite—Trimethylamine N-Oxide on Immunometabolism in Inflammatory Bowel Disease [PDF]
Frontiers in ImmunologyYumeng Lin
exaly +2 more sources
Transient trimethylaminuria related to menstruation
BMC Medical Genetics, 2007 Background Trimethylaminuria, or fish odor syndrome, includes a transient or mild malodor caused by an excessive amount of malodorous trimethylamine as a result of body secretions.
Yamazaki Hiroshi +2 more
doaj +1 more source
Analysis of metabolomic patterns in thoroughbreds before and after exercise [PDF]
Asian-Australasian Journal of Animal Sciences, 2017 Objective Evaluation of exercise effects in racehorses is important in horseracing industry and animal health care. In this study, we compared metabolic patterns between before and after exercise to screen metabolic biomarkers for exercise effects in ...
Hyun-Jun Jang +8 more
doaj +1 more source
Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients [PDF]
Journal of the American Society of Nephrology, 2016 Cardiovascular disease causes over 50% of the deaths in dialysis patients, and the risk of death is higher in white than in black patients. The underlying mechanisms for these findings are unknown. We determined the association of the proatherogenic metabolite trimethylamine N-oxide (TMAO) with cardiovascular outcomes in hemodialysis patients and ...
Tariq, Shafi +8 more
openaire +2 more sources
Gut‒heart axis: emerging therapies targeting trimethylamine N-oxide production
Gut MicrobesTrimethylamine N-oxide (TMAO) has garnered considerable attention because of its role in the pathophysiology and pathogenesis of various disorders, particularly heart and kidney disease.
Efrain Ricardo Torres +2 more
doaj +1 more source