Results 31 to 40 of about 17,902 (222)

Intestinal Microbiota Metabolism and Atherosclerosis

Chinese Medical Journal, 2015
Objective: This review aimed to summarize the relationship between intestinal microbiota metabolism and cardiovascular disease (CVD) and to propose a novel CVD therapeutic target.
Tian-Xing Liu, Hai-Tao Niu, Shu-Yang Zhang   +2 more
doaj   +1 more source

TMAO metaorganismal pathway and chronic inflammatory diseases [PDF]

Exploration of Medicine
Nutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA.
Zeneng Wang, Shumei Man, Robert Koeth
doaj   +1 more source

Analysis of metabolomic patterns in thoroughbreds before and after exercise [PDF]

Asian-Australasian Journal of Animal Sciences, 2017
Objective Evaluation of exercise effects in racehorses is important in horseracing industry and animal health care. In this study, we compared metabolic patterns between before and after exercise to screen metabolic biomarkers for exercise effects in ...
Hyun-Jun Jang, Duk-Moon Kim, Kyu-Bong Kim, Jeong-Woong Park, Jae-Young Choi, Jin Hyeog Oh, Ki-Duk Song, Suhkmann Kim, Byung-Wook Cho   +8 more
doaj   +1 more source

Association of diet with circulating trimethylamine-N-oxide concentration [PDF]

The American Journal of Clinical Nutrition, 2020
Trimethylamine-N-oxide (TMAO) is a compound that is present in seafood and produced through human gut microbial metabolism of its precursors. Previous studies have suggested that elevated TMAO concentrations are associated with an increased risk of cardiovascular events. However, the association between diet and TMAO concentrations in free-living adult
Rikuta Hamaya, Kerry L Ivey, Dong H Lee, Molin Wang, Jun Li, Adrian Franke, Qi Sun, Eric B Rimm   +7 more
openaire   +2 more sources

Transient trimethylaminuria related to menstruation

BMC Medical Genetics, 2007
Background Trimethylaminuria, or fish odor syndrome, includes a transient or mild malodor caused by an excessive amount of malodorous trimethylamine as a result of body secretions.
Yamazaki Hiroshi, Cashman John R, Shimizu Makiko   +2 more
doaj   +1 more source

Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients [PDF]

Journal of the American Society of Nephrology, 2016
Cardiovascular disease causes over 50% of the deaths in dialysis patients, and the risk of death is higher in white than in black patients. The underlying mechanisms for these findings are unknown. We determined the association of the proatherogenic metabolite trimethylamine N-oxide (TMAO) with cardiovascular outcomes in hemodialysis patients and ...
Tariq, Shafi, Neil R, Powe, Timothy W, Meyer, Seungyoung, Hwang, Xin, Hai, Michal L, Melamed, Tanushree, Banerjee, Josef, Coresh, Thomas H, Hostetter   +8 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria

mSystems, 2021
The gut microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) is linked to an increased risk for cardiovascular diseases. Trimethylamine (TMA), which is subsequently oxidized to TMAO in the liver, is formed by intestinal bacteria via distinct ...
Silke Rath, Katharina Rox, Sven Kleine Bardenhorst, Ulf Schminke, Marcus Dörr, Julia Mayerle, Fabian Frost, Markus M. Lerch, André Karch, Mark Brönstrup, Dietmar H. Pieper, Marius Vital   +11 more
doaj   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide [PDF]

APMIS, 2020
The increasing prevalence of cardiovascular diseases cannot adequately be explained by traditional risk factors. Recently, accumulating evidence has suggested that gut microbiota‐derived numerous metabolites are contributors to atherosclerotic events.
Zhu, Yingqian, Li, Qingqing, Jiang, Hua
openaire   +2 more sources