Onset and recurrence of psychiatric disorders associated with anti-hypertensive drug classes
The major anti-hypertensive (AHT) drug classes have been associated with differential risks of psychiatric disorders. However, existing data are limited largely to depression, and confounding variables have not always been controlled for.
Lucy Colbourne +2 more
doaj +1 more source
Antibiotics Significantly Decrease the Survival of Head and Neck Carcinoma Patients with Immunotherapy: A Real-World Analysis of More Than 3000 Cases [PDF]
Simple Summary: It is well known that antibiotics alter the gut microbiome, and because it plays a role in drug metabolism, alterations to the microbiome may lead to ineffective immunotherapy in cancer patients.
Heiland, Max +4 more
core +1 more source
Using real-world evidence data and digital monitoring to analyze the hepatotoxic profiles of biologics across more than two million patients [PDF]
The real-world evidence data from multiple sources which includes information on patient health status and medical behavior in routine clinical setup can give deeper insights into drugs 'safety and efficacy.
Banerjee, Priyanka +2 more
core +1 more source
Sex and age effects on risk of non-traumatic subarachnoid hemorrhage: retrospective cohort study of 124,234 cases using electronic health records [PDF]
Objectives: The epidemiology of non-traumatic subarachnoid hemorrhage (SAH) is unclear. This study describes the antecedent characteristics of SAH patients, compares the risk of SAH between women and men, and explores if this changes with age.
Harrison, Charlotte +4 more
core +2 more sources
Risk of myocardial infarction and ischemic stroke in individuals with first-diagnosed paroxysmal vs. non-paroxysmal atrial fibrillation under anticoagulation [PDF]
AimsThere is conflicting evidence on whether the type of atrial fibrillation (AF) is associated with risk of cardiovascular events, including acute myocardial infarction (MI) and ischemic stroke.
Abdul-Rahim, Azmil +6 more
core +2 more sources
Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States:A federated electronic medical record analysis [PDF]
BACKGROUND: At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19.
Fazio-Eynullayeva, Elnara +4 more
core +1 more source
Real‐world evidence from over one million COVID‐19 vaccinations is consistent with reactivation of the varicella‐zoster virus [PDF]
Background Reactivation of the varicella-zoster virus (VZV), which causes herpes zoster (HZ, synonym: shingles) in humans, can be a rare adverse reaction to vaccines. Recently, reports of cases after COVID-19 vaccination have arisen.
Bourne, P.E. +7 more
core +1 more source
Background It remains uncertain if prior use of oral anticoagulants (OACs) in COVID-19 outpatients with multimorbidity impacts prognosis, especially if cardiometabolic diseases are present. Clinical outcomes 30-days after COVID-19 diagnosis were compared
José Miguel Rivera-Caravaca +6 more
doaj +1 more source
Identification of risk factors and sequelae of any given disease is of key importance. For common diseases, primary prevention and disease management are based on this knowledge.
Khalaf Kridin +8 more
doaj +1 more source
GLP-1RA use improves outcomes post partial nephrectomy in T2DM patients with RCC: A TriNetX study. [PDF]
Abstract Objectives The purpose of this study is to investigate the impact of Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) use on 90‐day postoperative outcomes and overall survival following partial nephrectomy (PN) for renal cell carcinoma (RCC), where type 2 diabetes mellitus (T2DM) is a common comorbidity.
Kwon S +7 more
europepmc +2 more sources

