Atrial fibrillation and the risk of 30‐day incident thromboembolic events, and mortality in adults ≥ 50 years with COVID‐19 [PDF]
Journal of Arrhythmia, 2021 Background There are limited data on the outcomes of adults with coronavirus disease 2019 (COVID‐19) and atrial fibrillation (AF). The objectives were to (i) examine associations between AF, 30‐day thromboembolic events and mortality in adults with COVID‐
Stephanie L. Harrison +4 more
doaj +2 more sources
TriNetX and Real-World Evidence: A Critical Review of Its Strengths, Limitations, and Bias Considerations in Clinical Research [PDF]
ASIDE Internal MedicineIntroduction: The increasing utilization of real-world data platforms in medical research necessitates a comprehensive understanding of their methodological strengths and limitations.
Mahmoud Nassar +9 more
doaj +3 more sources
Choosing real-world data for clinical and epidemiological research: methodological lessons from NHIRD and TriNetX—A narrative review [PDF]
Annals of MedicineIntroduction Large-scale real-world data (RWD) are increasingly used in clinical and epidemiological research, although database-specific structures and limitations may affect study validity and applicability.
Teng-Li Lin, Yi-Ju Chen, Chun-Ying Wu
doaj +2 more sources
Real-World Epidemiological Analysis of Gastrointestinal Neuroendocrine Carcinomas: A TriNetX-Based Study [PDF]
ASIDE Internal MedicineIntroduction: Gastrointestinal neuroendocrine carcinomas (GI-NECs) are a diverse group of aggressive tumors with variable clinical outcomes. Although progress has been made in classifying and treating these cancers, detailed real-world data on their ...
Azzam, Ahmed Y. +6 more
core +3 more sources
Association of uveitis with pediatric autoimmune diseases based on a TriNetX study
Scientific ReportsTo investigate for the risk of uveitis among such patients. A retrospective cohort study utilized the TriNetX database and recruited pediatric autoimmune patients diagnosed between January 1st 2004 and December 31st 2022.
Alan Y. Hsu +10 more
doaj +3 more sources
Assessing Uveitis Risk following Pediatric Down Syndrome Diagnosis: A TriNetX Database Study
MedicinaBackground and Objectives: The risks of uveitis development among pediatric patients with Down syndrome (DS) remain unclear. Therefore, we aimed to determine the risk of uveitis following a diagnosis of DS. Materials and Methods: This multi-institutional
Alan Y. Hsu +9 more
doaj +3 more sources
MedicinaBackground and Objectives: Patients with previous acute myocardial infarction are at significantly higher risk of recurrent events. Early and intensive lipid-lowering therapy targeting low-density lipoprotein cholesterol is a key strategy for reducing ...
Grete Talviste +3 more
doaj +3 more sources
Hematology Reports, 2023 Paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired hematologic disorder, can be treated with C5 inhibitors (C5i) such as eculizumab or ravulizumab.
Jesse Fishman +4 more
doaj +1 more source
Comparison of five-year survival rates among patients with oral squamous cell carcinoma with and without association with syphilis: a retrospective case-control study [PDF]
, 2022 Background: Syphilis is an infectious disease that is at least discussed to be premalignant. This potential, combined with its general pathological impact, raises the question if syphilis increases mortality in oral cancer patients.
Dommisch, Henrik +6 more
core +1 more source
EBioMedicine, 2023 Summary: Background: Pancreatic Duct Adenocarcinoma (PDAC) screening can enable early-stage disease detection and long-term survival. Current guidelines use inherited predisposition, with about 10% of PDAC cases eligible for screening.
Kai Jia +7 more
doaj +1 more source