Results 41 to 50 of about 5,693 (231)

Real-time Prediction of COVID-19 related Mortality using Electronic Health Records

, 2020
Coronavirus Disease 2019 (COVID-19) is an emerging respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with rapid human-to-human transmission and a high case fatality rate particularly in older patients.
Bauer, Stefan, Celi, Leo Anthony, Hetzel, Jürgen, Hofer, Markus, Mehrjou, Arash, Parbhoo, Sonali, Schwab, Patrick, Schölkopf, Bernhard   +7 more
core   +1 more source

Allergic Rhinitis Amplifies Asthma Risk in Patients With Chronic Rhinosinusitis: A Large‐Scale Retrospective Cohort Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley   +1 more source

Intravascular Lithotripsy Is Associated With Superior Clinical Outcomes Compared to Atherectomy: A Large‐Scale, Propensity‐Matched Analysis

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary artery disease (CAD) with severe calcification remains a growing challenge in percutaneous coronary intervention (PCI). Atherectomy (ATH) has long been used for plaque modification, whereas intravascular lithotripsy (IVL) has emerged as a promising alternative. Large‐scale comparative data on long‐term outcomes are limited.
Charles D. Miks, Grant K. Ozaki, Chirayu R. Shukla, Vikram Sharma   +3 more
wiley   +1 more source

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, EarlyView.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Real-World Effectiveness of Bebtelovimab Versus Nirmatrelvir/Ritonavir in Outpatients with COVID-19

Pulmonary Therapy
Introduction This real-world study assessed the effectiveness of bebtelovimab (BEB) versus nirmatrelvir/ritonavir (NR) among outpatients with COVID-19 during the Omicron variant era.
Christopher G. Rowan, Russell M. Nichols, Neil Dhopeshwarkar, Jennifer M. Alyea, Baojin Zhu, Sengwee Toh, K. Arnold Chan, Elsie L. Grace   +7 more
doaj   +1 more source

Incidence and survival outcomes of myocarditis and pericardial diseases associated with immune checkpoint inhibitor therapy. [PDF]

INTRODUCTION: Immune checkpoint inhibitor(ICI) induced cardiac immune related adverse events are challenging to study; Leveraging large data bases like TriNetX global health network may provide needed insights.
Doh, Jean, Hamano, Hirofumi, Lee, Benjamin, Nagasaka, Misako, Naqvi, Ali, Nowrouzi, Nareh, Ozaki, Aya, Patel, Pranav, Sayer, Michael, Zamami, Yoshito   +9 more
core   +1 more source

Complications in Endoscopic Sinus Surgery: A TriNetX Network Analysis

International Forum of Allergy & Rhinology
AbstractBackgroundThe potential complications of endoscopic sinus surgery (ESS) remain a critical surgical consideration. This study aims to examine complication rates and identify trends in ESS‐related complications.MethodsThe TriNetX network was queried for patients undergoing ESS between 2005 and 2024.
Jakob L. Fischer, Tyler J. Gallagher, Matthew E. Lin, Ian Kim, Bozena B. Wrobel, Daniel M. Beswick, Jivianne T. Lee, Marilene B. Wang, Jeffrey D. Suh   +8 more
openaire   +1 more source

Trends in Management of Ménière Disease: A TriNetX Network Database Analysis

OTO Open
AbstractThis study investigated management practices for Meniere's disease (MD) and their temporal trends from 2008 to 2022 within the TriNetX network database. Study cohort included adult patients (≥18 years) with the diagnosis of MD from TriNetX's multi‐institutional medical records (n = 77,493).
Tyler J. Gallagher, Meredith E. Adams, Janet S. Choi   +2 more
openaire   +3 more sources

Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment‐Naive Patients Compared With Zoledronate

Clinical Pharmacology &Therapeutics, EarlyView.
We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu, Shiow‐Ing Wang, Shun‐Fa Yang   +2 more
wiley   +1 more source

Treating Type 2 Diabetes With Early, Intensive, Multimodal Pharmacotherapy: Real-World Evidence From an International Collaborative Database

Journal of Diabetes Research
Conclusions: In this real-world study, early, intensive polytherapy, targeting the distinct pathophysiological defects in T2D, is associated with significantly more favourable cardiorenal outcomes, compared to insulin and SU therapy.
Matthew Anson, Ayesha Malik, Sizheng S. Zhao, Philip Austin, Gema H. Ibarburu, Shabbar Jaffar, Anupam Garrib, Daniel J. Cuthbertson, Uazman Alam   +8 more
doaj   +1 more source