Neuromuscular dysfunction and pathogenesis in triosephosphate isomerase deficiency [PDF]
Scientific ReportsTriosephosphate isomerase deficiency (TPI Df) is a rare multisystem disorder with severe neuromuscular symptoms which arises exclusively from mutations within the TPI1 gene.
Tracey D. Myers +11 more
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Human Triosephosphate Isomerase Is a Potential Target in Cancer Due to Commonly Occurring Post-Translational Modifications [PDF]
Molecules, 2023 Cancer involves a series of diseases where cellular growth is not controlled. Cancer is a leading cause of death worldwide, and the burden of cancer incidence and mortality is rapidly growing, mainly in developing countries. Many drugs are currently used,
Sergio Enríquez-Flores +5 more
doaj +3 more sources
Newly discovered roles of triosephosphate isomerase including functions within the nucleus [PDF]
Molecular Medicine, 2023 Triosephosphate isomerase (TPI) is best known as a glycolytic enzyme that interconverts the 3-carbon sugars dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). TPI is an essential enzyme that is required for the catabolism of DHAP and
Tracey D. Myers, Michael J. Palladino
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Identification of fibrillogenic regions in human triosephosphate isomerase [PDF]
PeerJ, 2016 Background. Amyloid secondary structure relies on the intermolecular assembly of polypeptide chains through main-chain interaction. According to this, all proteins have the potential to form amyloid structure, nevertheless, in nature only few proteins ...
Edson N. Carcamo-Noriega +1 more
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Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target [PDF]
Biomolecules, 2020 Therapeutic strategies for the treatment of any severe disease are based on the discovery and validation of druggable targets. The human genome encodes only 600–1500 targets for small-molecule drugs, but posttranslational modifications lead to a ...
Sergio Enríquez-Flores +7 more
doaj +3 more sources
Comparative Transcriptome Analysis of Litopenaeus vannamei Reveals That Triosephosphate Isomerase-Like Genes Play an Important Role During Decapod Iridescent Virus 1 Infection [PDF]
Frontiers in Immunology, 2020 Decapod iridescent virus 1 (DIV1) results in severe economic losses in shrimp aquaculture. However, little is known about the physiological effect of DIV1 infection on the host. In this study, we found that the lethal dose 50 of DIV1-infected Litopenaeus
Xuzheng Liao +10 more
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Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity [PDF]
Veterinary Sciences, 2018 The cattle tick Rhipicephalus microplus is one of the most important ectoparasites causing significant economic losses for the cattle industry. The major tool of control is reducing the number of ticks, applying acaricides in cattle. However, overuse has
Luiz Saramago +14 more
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Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment. [PDF]
Mem Inst Oswaldo Cruz, 2018 BACKGROUND The current chemotherapy for Chagas disease is based on monopharmacology with low efficacy and drug tolerance. Polypharmacology is one of the strategies to overcome these limitations.
Aguilera E +8 more
europepmc +4 more sources
Clinical significance and prognostic value of Triosephosphate isomerase expression in gastric cancer. [PDF]
Medicine (Baltimore), 2017 Triosephosphate isomerase (TPI) is highly expressed in many human cancers and is involved in migration and invasion of cancer cells. However, TPI clinicopathological significance and prognostic value in gastric cancer (GC) are not yet well defined.
Chen T +8 more
europepmc +3 more sources
Triosephosphate isomerase: the perfect enzyme, but how does it work? [PDF]
IUCrJ, 2021 John R. Helliwell
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