Results 111 to 120 of about 45,786 (250)

Theoretical Improvements in Enzyme Efficiency Associated with Noisy Rate Constants and Increased Dissipation

Entropy
Previous studies have revealed the extraordinarily large catalytic efficiency of some enzymes. High catalytic proficiency is an essential accomplishment of biological evolution.
Davor Juretić, Željana Bonačić Lošić   +1 more
doaj   +1 more source

Trypanosoma evansi is alike to Trypanosoma brucei brucei in the subcellular localisation of glycolytic enzymes

Memorias do Instituto Oswaldo Cruz, 2015
Trypanosoma evansi, which causes surra, is descended from Trypanosoma brucei brucei, which causes nagana. Although both parasites are presumed to be metabolically similar, insufficient knowledge of T. evansi precludes a full comparison.
S Andrea Moreno, Mayerly Nava
doaj   +1 more source

Label‐Free Proteomic Profiling of the dvls2 (CL2006) Caenorhabditis elegans Alzheimer's Disease (AD) Model Reveals Conserved Molecular Signatures Shared With the Human AD Brain

Journal of Neurochemistry, Volume 169, Issue 7, July 2025.
Cross‐species analysis combining C. elegans proteomics and Alzheimer's disease brain transcriptomics reveals shared alterations in stress response, metabolism, and protein homeostasis, highlighting eEF‐2 as a conserved key regulator. ABSTRACT Alzheimer's disease (AD) is the most common form of dementia, posing significant challenges to cognitive ...
Iverson Conrado Bezerra, Emily Raphaely Souza dos Santos, Katarine G. Aurista do Nascimento, Artur José da Silva, Josivan Barbosa de Farias, Maria Luiza de Lima Vitorino, Roberto Afonso da Silva, José Luiz de Lima Filho, Priscila Gubert   +8 more
wiley   +1 more source

The effects of photodynamic treatment with new methylene blue N on the Candida albicans proteome. [PDF]

, 2016
Candida albicans is a human pathogenic fungus mainly affecting immunocompromised patients. Resistance to the commonly used fungicides can lead to poor treatment of mucosal infections which, in turn, can result in life-threatening systemic candidiasis. In
Braga, GÚL, Brancini, GTP, Izumi, C, Rambaldi, MDSL, Rodrigues, GB, Rosa, JC, Wainwright, M, Yatsuda, AP   +7 more
core   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, Volume 19, Issue 6, Page 1725-1736, June 2025.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Isolation and Characterization of Triosephosphate Isomerase Isozymes from Human Placenta [PDF]

, 1981
Two isozymes of triosephosphate isomerase have been isolated to homogeneity from human placenta. Triosephosphate isomerase A and triosephosphate isomerase B were compared in terms of their chemical, and biological ...
Dewan, Rahul Nath
core  

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. [PDF]

, 2014
The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide and amino acid biosynthesis, to provide reducing molecules for anabolism ...
Breitenbach, Michael, Brindle, Kevin M, Campbell, Kate, Cheung, Eric, Cramer, Thorsten, Grüning, Nana-Maria, Keller, Markus A, Krüger, Antje, Olin-Sandoval, Viridiana, Prigione, Alessandro, Rabinowitz, Joshua D, Ralser, Markus, Stincone, Anna, Tauqeer Alam, Mohammad, Wamelink, Mirjam MC   +14 more
core   +5 more sources

The effect of serum withdrawal on the protein profile of quiescent human dermal fibroblasts in primary cell culture [PDF]

, 2008
The effect of serum deprivation on proliferating cells is well known, in contrast its role on primary cell cultures, at confluence, has not been deeply investigated.
ANNOVI, Giulia, BORALDI, Federica, PAOLINELLI DEVINCENZI, Chiara, QUAGLINO, Daniela, TIOZZO, Roberta   +4 more
core   +1 more source

Purification and Partial Characterization of Trypanosoma cruzi Triosephosphate Isomerase

Memorias do Instituto Oswaldo Cruz, 1998
The enzyme triosephosphate isomerase (TPI, EC 5.3.1.1) was purified from extracts of epimastigote forms of Trypanosoma cruzi. The purification steps included: hydrophobic interaction chromatography on phenyl-Sepharose, CM-Sepharose, and high performance ...
Bourguignon SC, Meirelles MN, Pacheco RS, De Simone S Giovanni   +3 more
doaj  

Is Deuterium Sequestering by Reactive Carbon Atoms an Important Mechanism to Reduce Deuterium Content in Biological Water?

FASEB BioAdvances, Volume 7, Issue 6, June 2025.
Deuterium, a heavy isotope of hydrogen, is universal in nature, but it disrupts the mitochondrial ATPase pumps. One mechanism that biological organisms may use to reduce deuterium levels in the mitochondria is to sequester deuterium bound to carbon atoms in a small set of organic molecules that have a unique configuration to support such trapping ...
Stephanie Seneff, Greg Nigh, Anthony M. Kyriakopoulos   +2 more
wiley   +1 more source