Triosephosphate isomerase: the perfect enzyme, but how does it work? [PDF]
IUCrJ, 2021 John R. Helliwell
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Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Trypanosoma cruzi is the causative agent of American trypanosomiasis, which mainly affects populations in Latin America. Benznidazole is used to control the disease, with severe effects in patients receiving this chemotherapy.
Itzhel García-Torres +9 more
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Human Triosephosphate Isomerase Is a Potential Target in Cancer Due to Commonly Occurring Post-Translational Modifications [PDF]
Molecules, 2023 Cancer involves a series of diseases where cellular growth is not controlled. Cancer is a leading cause of death worldwide, and the burden of cancer incidence and mortality is rapidly growing, mainly in developing countries. Many drugs are currently used,
Sergio Enríquez-Flores +5 more
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Triosephosphate-Isomerase Deficiency: Epiphenomenon or Cause of Loin Pain Haematuria Syndrome? [PDF]
Case Reports in Nephrology and Dialysis, 2022 A 32-year-old male patient presented the clinical picture of loin pain haematuria syndrome with pain attacks accompanied by macrohaematuria. In renal biopsy, the preglomerular vessels showed segmental wall hyalinosis in the sense of low-grade ...
Hans-Joachim Schurek +4 more
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Identification of fibrillogenic regions in human triosephosphate isomerase [PDF]
PeerJ, 2016 Background. Amyloid secondary structure relies on the intermolecular assembly of polypeptide chains through main-chain interaction. According to this, all proteins have the potential to form amyloid structure, nevertheless, in nature only few proteins ...
Edson N. Carcamo-Noriega +1 more
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Child Neurology: Triosephosphate isomerase deficiency [PDF]
Neurology, 2020 Triosephosphate isomerase (TPI) deficiency is a rare autosomal recessive disease of infancy and childhood classified as a glycolytic enzymopathy. Clinical features include hemolytic anemia, progressive neuromuscular dysfunction, and increased susceptibility to infection with specific pathogenic variants resulting in severe disease and death by age 8 ...
Corrie Harris +6 more
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Newly discovered roles of triosephosphate isomerase including functions within the nucleus [PDF]
Molecular Medicine, 2023 Triosephosphate isomerase (TPI) is best known as a glycolytic enzyme that interconverts the 3-carbon sugars dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). TPI is an essential enzyme that is required for the catabolism of DHAP and
Tracey D. Myers, Michael J. Palladino
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mBio, 2014 Triosephosphate isomerase (TPI) catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). This reaction is required for glycolysis and gluconeogenesis, and tpi has been predicted to be essential for growth ...
Carolina Trujillo +5 more
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Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target [PDF]
Biomolecules, 2020 Therapeutic strategies for the treatment of any severe disease are based on the discovery and validation of druggable targets. The human genome encodes only 600–1500 targets for small-molecule drugs, but posttranslational modifications lead to a ...
Sergio Enríquez-Flores +7 more
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Murine model of triosephosphate isomerase deficiency with anemia and severe neuromuscular dysfunction [PDF]
Current Research in Neurobiology, 2022 Triosephosphate isomerase deficiency (TPI Df) is a rare, aggressive genetic disease that typically affects young children and currently has no established treatment. TPI Df is characterized by hemolytic anemia, progressive neuromuscular degeneration, and
Tracey D. Myers +4 more
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