Difference FTIR Studies of Substrate Distribution in Triosephosphate Isomerase. [PDF]
J Phys Chem B, 2017 Triosephosphate isomerase (TIM) catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde 3-phosphate (GAP), via an enediol(ate) intermediate.
Deng H +3 more
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Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Trypanosoma cruzi is the causative agent of American trypanosomiasis, which mainly affects populations in Latin America. Benznidazole is used to control the disease, with severe effects in patients receiving this chemotherapy.
Itzhel García-Torres +9 more
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Acta Pharmaceutica, 2021 Trichomoniasis is a public health problem worldwide. Trichomoniasis treatment consists of the use of nitroimidazole derivatives; however, therapeutic ineffectiveness occurs in 5 to 20 % of the cases.
Palos Isidro +7 more
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Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps. [PDF]
IUCrJ, 2021 The high-resolution neutron structure of triosephosphate isomerase was determined in complex with two inhibitors that mimic intermediate states in the reaction mechanism.
Kelpšas V +7 more
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Triosephosphate-Isomerase Deficiency: Epiphenomenon or Cause of Loin Pain Haematuria Syndrome? [PDF]
Case Reports in Nephrology and Dialysis, 2022 A 32-year-old male patient presented the clinical picture of loin pain haematuria syndrome with pain attacks accompanied by macrohaematuria. In renal biopsy, the preglomerular vessels showed segmental wall hyalinosis in the sense of low-grade ...
Hans-Joachim Schurek +4 more
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Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples. [PDF]
Front Immunol, 2021 Metabolic intervention is a novel anti-rheumatic approach. The glycolytic regulator NAMPT has been identified as a therapeutic target of rheumatoid arthritis (RA), while other metabolic regulators coordinating NAMPT to perpetuate inflammation are yet to ...
Lei M +8 more
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Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2017 Giardiasis, the infestation of the intestinal tract by Giardia lamblia, is one of the most prevalent parasitosis worldwide. Even though effective therapies exist for it, the problems associated with its use indicate that new therapeutic options are ...
Adriana Castillo-Villanueva +7 more
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Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity. [PDF]
Sci Rep, 2020 Trematode infections such as schistosomiasis and fascioliasis cause significant morbidity in an estimated 250 million people worldwide and the associated agricultural losses are estimated at more than US$ 6 billion per year.
Ferraro F +12 more
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Disease Models & Mechanisms, 2022 Triosephosphate isomerase (TPI) deficiency (TPI Df) is an untreatable glycolytic enzymopathy that results in hemolytic anemia, progressive muscular impairment and irreversible brain damage.
Andrew P. VanDemark +8 more
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Murine model of triosephosphate isomerase deficiency with anemia and severe neuromuscular dysfunction [PDF]
Current Research in Neurobiology, 2022 Triosephosphate isomerase deficiency (TPI Df) is a rare, aggressive genetic disease that typically affects young children and currently has no established treatment. TPI Df is characterized by hemolytic anemia, progressive neuromuscular degeneration, and
Tracey D. Myers +4 more
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