Results 21 to 30 of about 45,786 (250)

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency. [PDF]

J Inherit Metab Dis, 2019
Triosephosphate isomerase (TPI) deficiency is a fatal genetic disorder characterized by hemolytic anemia and neurological dysfunction. Although the enzyme defect in TPI was discovered in the 1960s, the exact etiology of the disease is still debated. Some
Segal J, Mülleder M, Krüger A, Adler T, Scholze-Wittler M, Becker L, Calzada-Wack J, Garrett L, Hölter SM, Rathkolb B, Rozman J, Racz I, Fischer R, Busch DH, Neff F, Klingenspor M, Klopstock T, Grüning NM, Michel S, Lukaszewska-McGreal B, Voigt I, Hartmann L, Timmermann B, Lehrach H, Wolf E, Wurst W, Gailus-Durner V, Fuchs H, H de Angelis M, Schrewe H, Yuneva M, Ralser M.   +31 more
europepmc   +2 more sources

Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity. [PDF]

Sci Rep, 2019
Fludioxonil, a natural product of pyrrolnitrin, is a potent fungicide used on crops worldwide. Drug action requires the presence of a group III hybrid histidine kinase (HHK) and the high osmolarity glycerol (HOG) pathway.
Brandhorst TT, Kean IRL, Lawry SM, Wiesner DL, Klein BS.   +4 more
europepmc   +2 more sources

Triosephosphate Isomerase and Its Product Glyceraldehyde-3-Phosphate Are Involved in the Regulatory Mechanism That Suppresses Exit from the Quiescent State in Yeast Cells [PDF]

Microbiology Spectrum, 2022
Cells of the budding yeast Saccharomyces cerevisiae form spores or stationary cells upon nutrient starvation. These quiescent cells are known to resume mitotic growth in response to nutrient signals, but the mechanism remains elusive.
Guoyu Liu, Yan Yang, Ganglong Yang, Shenglin Duan, Peng Yuan, Shuang Zhang, Feng Li, Xiao-Dong Gao, Hideki Nakanishi   +8 more
doaj   +2 more sources

Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation [PDF]

FEBS Open Bio, 2022
Recruitment of plasminogen is an important infection strategy of the human pathogen Streptococcus pneumoniae to invade host tissues. In Streptococcus aureus, triosephosphate isomerase (TPI) has been reported to bind plasminogen. In this study, the TPI of
Satoru Hirayama, Hisanori Domon, Takumi Hiyoshi, Toshihito Isono, Hikaru Tamura, Karin Sasagawa, Fumio Takizawa, Yutaka Terao   +7 more
doaj   +2 more sources

First characterization of a microsporidial triosephosphate isomerase and the biochemical mechanisms of its inactivation to propose a new druggable target. [PDF]

Sci Rep, 2018
The microsporidia are a large group of intracellular parasites with a broad range of hosts, including humans. Encephalitozoon intestinalis is the second microsporidia species most frequently associated with gastrointestinal disease in humans, especially ...
García-Torres I, De la Mora-De la Mora I, Hernández-Alcántara G, Molina-Ortiz D, Caballero-Salazar S, Olivos-García A, Nava G, López-Velázquez G, Enríquez-Flores S.   +8 more
europepmc   +2 more sources

Cytosolic Triosephosphate Isomerase from Arabidopsis thaliana Is Reversibly Modified by Glutathione on Cysteines 127 and 218 [PDF]

Frontiers in Plant Science, 2016
In plant cells, an increase in cellular oxidants can have multiple effects, including the promotion of mixed disulfide bonds between glutathione and some proteins (S-glutathionylation). The present study focuses on the cytosolic isoform of the glycolytic
S. Dumont, N. Bykova, G. Pelletier, S. Dorion, J. Rivoal   +4 more
semanticscholar   +2 more sources

Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase. [PDF]

J Am Chem Soc, 2017
Triosephosphate isomerase (TIM) is a proficient catalyst of the reversible isomerization of dihydroxyacetone phosphate (DHAP) to d-glyceraldehyde phosphate (GAP), via general base catalysis by E165.
Kulkarni YS, Liao Q, Petrović D, Krüger DM, Strodel B, Amyes TL, Richard JP, Kamerlin SCL.   +7 more
europepmc   +2 more sources

Methylglyoxal-Induced Modifications in Human Triosephosphate Isomerase: Structural and Functional Repercussions of Specific Mutations [PDF]

Molecules
Triosephosphate isomerase (TPI) dysfunction is a critical factor in diverse pathological conditions. Deficiencies in TPI lead to the accumulation of toxic methylglyoxal (MGO), which induces non-enzymatic post-translational modifications, thus ...
Ignacio de la Mora-de la Mora, Itzhel García-Torres, Luis Antonio Flores-López, Gabriel López-Velázquez, Gloria Hernández-Alcántara, Saúl Gómez-Manzo, Sergio Enríquez-Flores   +6 more
doaj   +2 more sources

Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase. [PDF]

J Am Chem Soc, 2018
We have previously performed empirical valence bond calculations of the kinetic activation barriers, ΔG‡calc, for the deprotonation of complexes between TIM and the whole substrate glyceraldehyde-3-phosphate (GAP, Kulkarni et al.J. Am. Chem.
Kulkarni YS, Liao Q, Byléhn F, Amyes TL, Richard JP, Kamerlin SCL.   +5 more
europepmc   +2 more sources

Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis [PDF]

Open Biology, 2014
The inhibition of triosephosphate isomerase (TPI) in glycolysis by the pyruvate kinase (PK) substrate phosphoenolpyruvate (PEP) results in a newly discovered feedback loop that counters oxidative stress in cancer and actively respiring cells.
Nana-Maria Grüning, Dijun Du, Markus A. Keller, Ben F. Luisi, Markus Ralser   +4 more
doaj   +5 more sources